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The predictive edge: modeling and simulation in drug product development.

It is well-known that drug development is challenging and a time- and resource-intensive endeavor. Historically, it has relied heavily on trial-and-error, empirical approaches that yield a low probability of success. Despite continuous efforts to improve efficiency across the development stages the overall success rate from clinical trial initiation to market approval remains low. In response to t...

Jan 25 2026 41592638

Sorafenib nanomedicine in HCC: nano-bio interactions and combination therapies.

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with systemic therapies offering only limited benefit. Sorafenib, the first-line multi-kinase inhibitor, is constrained by poor pharmacokinetics, dose-limiting toxicities, and the rapid emergence of resistance. Nanotechnology-based drug delivery systems (NDDS) provide promising strategies to address these...

Jan 23 2026 41578333
DualSightNet: A novel dual architecture for visual quality control of railway infrastructure.

To ensure the operational safety of trains, it is essential to monitor the condition of the rails. In order to detect problems ranging from wear and t...

Jan 23 2026 41576054
Interfacial Modification of Nanochannels for Enhanced Detection Accuracy in Complex Matrices.

Solid-state nanochannels, as an emerging single-molecule sensing platform, have shown great potential in environmental monitoring, biomedical diagnost...

Jan 22 2026 41572469
Recent advances in the analysis of the evolutionary RNA based therapeutics; a review.

The evolution of RNA-based therapies is bringing in a new era for the pharmaceutical industry. As a result of their crucial role in regulation of gene...

Jan 22 2026 41580000
How do chronic diseases affect personal and household income? A double debiased machine learning analysis of the China health and retirement longitudinal study (CHARLS) in older adults.

OBJECTIVES: This study aimed to investigate the impacts of chronic diseases such as hypertension, dyslipidaemia and diabetes on personal and household...

Jan 22 2026 41571416
The effect of AI-assisted bedside echocardiography on inpatient care: a prospective trial.

AIMS: Focused cardiac ultrasound (FoCUS) can yield valuable information for decision-making. However, it is limited by the skills required to acquire ...

Jan 21 2026 41640419
Integrative analysis identifies lactylation-related biomarkers in sepsis via bioinformatics and machine learning.

BACKGROUND: Protein lactylation is a novel post-translational modification driven by lactate and has emerged as a critical link between cellular metab...

Jan 21 2026 41570698
Patient perceptions and attitudes towards the use of artificial intelligence in the symptomatic breast unit.

OBJECTIVES: Artificial intelligence (AI) has been applied in a number of breast screening settings with favourable results. While there are a limited ...

Jan 21 2026 41565794
Digital horizons: Exploring the future of AI-enabled gastroenterology in the Kingdom of Saudi Arabia.

Artificial intelligence is rapidly reshaping gastroenterology through demonstrable gains in diagnostic precision, procedural quality, and operational ...

Jan 21 2026 41566344
Therapeutic nanofibrous scaffolds in precision drug delivery: formulation design, challenges and regulatory frameworks.

INTRODUCTION: Drug-loaded nanofibrous systems represent a breakthrough in drug delivery, overcoming limitations of conventional formulations. They dem...

Jan 20 2026 41549842
Retinal Coronary Artery Calcium Scoring - A Scalable Tool for Life Insurers.

BACKGROUND.—: Cardiovascular risk estimation for life insurance underwriting relies on risk estimation from conventional metrics: age, sex, smoking st...

Jan 20 2026 41558685
Deep learning-based no-reference image quality assessment framework for Cryptosporidium spp. and Giardia spp.

Image Quality Assessment (IQA) plays a critical role in image-based decision-making systems, especially in domains requiring high diagnostic precision...

Jan 20 2026 41557673
Roles of microorganisms in the flavor evolution of prepared aquatic foods: comprehensively understanding their metabolic mechanisms, quorum sensing, and innovative regulation strategies.

Prepared aquatic foods refer to ready to eat, heat, cook, and use aquatic products. These foods are gaining popularity as a result of consumer prefere...

Jan 19 2026 41549679
Deep learning in stroke therapeutics: drug repurposing and beyond.

INTRODUCTION: Deep learning is reshaping stroke research by accelerating drug repurposing amid heterogeneous pathology, narrow therapeutic windows, an...

Jan 19 2026 41549848
Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.

Vascular Cognitive Impairment and Dementia (VCID), the second most common form of dementia, is becoming increasingly prevalent worldwide. However, cur...

Jan 19 2026 41554956
From Clusters to Outcomes: Machine Learning-Based Phenotyping in Intermediate-High-Risk Acute Pulmonary Embolism.

Intermediate-high-risk (IHR) pulmonary embolism (PE) represents a heterogeneous group in whom guideline-based criteria may insufficiently capture biol...

Jan 18 2026 41555848
Multi-task non-contact ballistocardiogram-based vital signs monitoring in acupuncture.

The study introduces an innovative approach for efficient vital signs monitoring in acupuncture by combining multi-channel ballistocardiogram (BCG) si...

Jan 17 2026 41548353
Ethical and Regulatory Considerations for Artificial Intelligence Adoption in Craniofacial Surgery.

Artificial intelligence (AI) continues to enhance surgical care, with growing applications in craniofacial surgery, including automated cephalometric ...

Jan 16 2026 41543479
Predicting the progression of difficult-to-treat rheumatoid arthritis by a machine learning scoring system, from the FIRST registry.

OBJECTIVES: This study aimed to develop and validate a prediction model for the future progression of difficult-to-treat rheumatoid arthritis (D2T RA)...

Jan 16 2026 41545312
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