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Reveal a risk and potential mechanism for keratoconus progression with isotretinoin: Toxicogenomic, transcriptomics and real-world evidence insights.

PURPOSE: Limited clinical data and unstable animal models hinder understanding isotretinoin-induced keratoconus. We addressed this by integrating pharmacovigilance with computational approaches. METHODS: Isotretinoin-associated ocular surface adverse events were extracted from the FDA Adverse Event Reporting System (FAERS). Disproportionality analyses detected pharmacovigilance signals, and age co...

Nov 22 2025 41285218

Factors influencing AI acceptance in radiology: a systematic review across the radiology workflow.

OBJECTIVES: Despite AI's promise for radiology, clinical implementation remains limited. AI acceptance is a key factor in bridging the gap between technical validation and adoption. This systematic review identifies factors influencing the acceptance and use of clinical AI tools across the radiology workflow. MATERIALS AND METHODS: A systematic search of Ovid Medline, Embase, and Web of Science Co...

Nov 21 2025 41269301
Advances in transcription factor-based biosensors for natural product biosynthesis: Optimization, emerging technologies, and future prospects.

Natural products (NPs) are increasingly applied in food, medicine, and biotechnology. However, their biosynthesis remains constrained by low titers an...

Nov 20 2025 41274426
Bridging tradition and innovation: Acupuncture for depression through clinical efficacy and neurobiological insights.

BACKGROUND: To elucidate the research progress on acupuncture therapy as a complementary and alternative medicine treatment for depression by reviewin...

Nov 19 2025 41265714
Accuracy of Photon Dose Calculation on Photon-Counting Computed Tomography-A Comparison Study Based on Virtual Monoenergetic and Electron Density (Rho) Images for Pancreatic Cases.

PURPOSE: Photon-counting computed tomography (PCCT) offers versatile anatomic information because of better energy discrimination and higher spatial r...

Nov 19 2025 41541756
Utility and limitations of the FDA adverse events reporting system public dashboard for safety analyses: a case study with vesicular monoamine transporter 2 inhibitors.

INTRODUCTION: The United States Food and Drug Administration (FDA) requires post-marketing surveillance of approved drugs, and pharmaceutical manufact...

Nov 17 2025 41212745
Effective alternative strategies to combat challenges associated with MDR bacterial infections: Drug repurposing, role of artificial intelligence, and novel therapeutic options.

Antibiotic failure has emerged as a critical global health concern, driven by a combination of factors including the stagnation in the discovery of ne...

Nov 17 2025 41274070
Identifying behavioral and biological predictors of cannabis vapor self-administration in rats.

The recent wave of recreational cannabis legalization in the US has underscored the importance of identifying predictors of individual variability in ...

Nov 14 2025 41238696
LBMS-SAM: Segment anything model guided SEM image segmentation for lithium battery materials.

We conduct a comprehensive study on the quality inspection of lithium battery materials, which evaluates material conformity by analyzing particle siz...

Nov 14 2025 41289643
Machine learning-assisted rapid screening of oil types on microfluidic thread-based analytical devices (μTADs).

BACKGROUND: Rapid and low-cost classification of oil and its derivatives is critically important for on-site inspection, quality monitoring, and field...

Nov 13 2025 41352937
Biogenic amines in fermented foods: A comprehensive review from formation pathways, risk analysis, detection technologies to control measures.

Biogenic amines (BAs), typically arising from the fermentation of protein-rich food matrices or products with extended fermentation cycles, posing sig...

Nov 13 2025 41360534
Key mechanisms of affective disorders : CRC/TRR 393 project on mechanisms of emotion regulation, expectation, social cognition, and cognitive-behavioral rhythms.

BACKGROUND: Although affective disorders are a major driver of disability worldwide, there is a lack of understanding of the mechanisms and modulating...

Nov 10 2025 41212184
Unconscious elevated bottom-up processing in depression: Insights from dynamic causal modeling with EEG and fMRI.

INTRODUCTION: MRI compatible EEG systems enable simultaneous EEG-fMRI data assessment, which provides high spatial and high temporal resolution of neu...

Nov 10 2025 41224023
Human or AI first? A holistic perspective on the sequential order of joint human-AI inspection workflows.

The complementary integration of artificial intelligence (AI) in the workplace requires balancing performance goals with psychological needs, as both ...

Nov 6 2025 41202444
Genetic Determinants and Breeding Strategies for Rice Cooking and Eating Quality: A Comprehensive Review.

Rice cooking and eating quality (CEQ), a core agronomic trait tied to consumer preference and market value, is regulated by endosperm starch, protein,...

Nov 4 2025 41186968
Deep learning-assisted surface-enhanced Raman spectroscopy detection of stimulants.

The abuse of stimulants poses a significant threat to public health and the integrity of competitive sports, necessitating the development of highly s...

Oct 31 2025 41176858
Advanced artificial intelligence combined with SERS platforms for diagnosis and therapeutic effects of cancer in clinical applications.

Surface-Enhanced Raman Spectroscopy (SERS) has become a valuable way to detect small amounts of molecules due to its high sensitivity. Nonetheless, ap...

Oct 31 2025 41207163
An interactive and explainable AI approach to improve human-machine teaming in cancer subtyping from digital cytopathology.

Algorithmic decision support is rapidly becoming a staple of personalized medicine, particularly for high-stakes recommendations such as cancer subtyp...

Oct 31 2025 41205246
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs.

The blood-brain barrier (BBB), crucial for central nervous system (CNS) homeostasis, poses challenges for drug delivery in CNS diseases due to selecti...

Oct 29 2025 41160380
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