Flu & URI

SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). SFTSV infection carries a high mortality rate and has emerged to be a public health concern. SFTSV infection could induce many classical cell death pathways. Ferroptosis, a novel iron-dependent form of regulated cell death, is shown to par...

Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.

BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumatic disease. The recently approved CHIKV vaccine, IXCHIQ, is based on a live-attenuated CHIKV strain (VLA1553), with viraemic vaccine recipients theoretically able to transmit VLA1553 to mosquitoes with ensuing onward transmission. We thus evaluated V...

Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.

Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure t...

Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.

Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 par...

A Review of Cross-Species Transmission Mechanisms of Influenza Viruses.

The cross-species transmission of influenza viruses represents a critical link in the pandemic of zoonotic diseases. This mechanism involves multi-lev...

Development and Clinical Evaluation of a Mpox Antigen-detecting Rapid Diagnostic Test.

To address the global emergence of mpox after the 2022 epidemic, a rapid and accurate diagnostic tool is needed at the point of care to identify indiv...

Technical validation of a multiplex real-time PCR for combined detection of Rift Valley fever, chikungunya, Zika and dengue viruses.

Several arthropod-borne (arbo)-viruses have overlapping symptoms, insect vectors and geographical occurrence. With little known about the importance o...

Serum Vitamin D and the Risk of SARS-CoV-2 and Seasonal Influenza Infection During the Twindemic Period.

BACKGROUND & AIMS: The association between circulating vitamin D levels and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) o...

A digital photography dataset for Vaccinia Virus plaque quantification using Deep Learning.

Virological plaque assay is the major method of detecting and quantifying infectious viruses in research and diagnostic samples. Furthermore, viral pl...

A systematic evaluation of the language-of-viral-escape model using multiple machine learning frameworks.

Predicting the evolutionary patterns of emerging and endemic viruses is key for mitigating their spread. In particular, it is critical to rapidly iden...

Pathogenicity and virulence of lumpy skin disease virus: A comprehensive update.

Lumpy skin disease (LSD), which was confined to the Africa for many decades, has expanded its geographical distribution to numerous countries across A...

Role of artificial intelligence in advancing immunology.

Artificial intelligence (AI) has revolutionized various biomedical fields, particularly immunology, by enhancing vaccine development, immunotherapies,...

Machine learning assessment of zoonotic potential in avian influenza viruses using PB2 segment.

BACKGROUND: Influenza A virus (IAV) is a major global health threat, causing seasonal epidemics and occasional pandemics. Particularly, Influenza A vi...

Detection and prevalence of avian influenza epidemic in the southwest of Poyang Lake and analysis of the influence of meteorological factors.

Recently, the epidemiological profile of avian influenza has changed dramatically worldwide. Avian influenza sampling and surveillance of wholesale an...

Deep recurrent neural network with fractional addax optimization algorithm for influenza virus host prediction.

The accurate prediction of the host of influenza viruses is a significant challenge in bioinformatics, as it is crucial for understanding viral transm...

Vaccinology in the artificial intelligence era.

Artificial intelligence (AI) has already transformed vaccine antigen design and could transform the entire vaccinology pipeline, including immune resp...

Constructing a screening model to identify patients at high risk of hospital-acquired influenza on admission to hospital.

OBJECTIVE: To develop a machine learning (ML)-based admission screening model for hospital-acquired (HA) influenza using routinely available data to s...

Enhancing fever of unknown origin diagnosis: machine learning approaches to predict metagenomic next-generation sequencing positivity.

OBJECTIVE: Metagenomic next-generation sequencing (mNGS) can potentially detect various pathogenic microorganisms without bias to improve the diagnost...

Evaluation of Different Machine Learning Approaches to Predict Antigenic Distance Among Newcastle Disease Virus (NDV) Strains.

Newcastle disease virus (NDV) continues to present a significant challenge for vaccination due to its rapid evolution and the emergence of new variant...

Analyzing the impact of COVID-19 on seasonal infectious disease outbreak detection using hybrid SARIMAX-LSTM model.

BACKGROUND: This study estimates the incidence of seasonal infectious diseases, including influenza, norovirus, severe fever with thrombocytopenia syn...