Latest AI and machine learning research in fungal infection for healthcare professionals.
Pneumocystis jirovecii is a fungal pathogen causing Pneumocystis pneumonia in humans, mainly in immunocompromised individuals. Infections by P. jirovecii are treated using the antifolate combination drug trimethoprim-sulfamethoxazole (TMP-SMX), targeting the dihydrofolate reductase (DHFR) and the dihydropteroate synthase (DHPS). In recent years, there has been an increase of treatment failure, wit...
Natural products (NPs) are key to biological function and adaptation, with their distribution shaped by complex evolutionary and ecological forces. While it may seem reasonable to assume that closely related species produce chemically similar NPs, this assumption has not been systematically tested at a broad taxonomic scale. Here, we evaluate whether evolutionary (taxonomic) proximity correlates w...
In hematopoietic cell transplant patients, intestinal Candida parapsilosis expansion and translocation cause life-threatening candidemia, yet how comm...
Skin infections have been described as the primary cause for presentation in veterinary small animal practices and they frequently result in prescript...
The ability of organisms to adapt and survive depends on the effects of genes and the environment on fitness. However, the multigenic nature of fitnes...
Plants rely on cell surface immune receptors to detect microbial patterns and initiate effective defense responses. Although the Asteraceae family is ...
Nonribosomal peptides are diverse natural products with important applications in medicine and agriculture. Bacterial and fungal genomes contain thous...
Saccharomycotina yeasts are a highly diverse and widely distributed subphylum of ascomycete fungi that exhibit diversity in their asexual growth morph...
Within host-microbiome-pathogen systems, the host chemical microenvironment is often overlooked despite its inherent role in host physiology. We used ...
3-Methylcrotonyl-CoA carboxylase (MCC) is a biotin-dependent carboxylase that metabolizes the amino acid leucine. MCC is present in bacteria, fungi, p...
mRNA design plays a central role in synthetic biology, nucleic acid therapeutics, and vaccine development. Although large language models are applied ...
Effectors are pathogen proteins that facilitate infection by manipulating plant immunity. Computational programs have been developed that identify eff...
Clinical microbiology laboratories play a crucial role in identifying pathogens, guiding antibiotic treatment, and managing antimicrobial resistance (...
This study provides an objective, in-depth overview of a large body of science output addressing public health. We apply topic modeling and bibliometr...
Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and all...
We developed and tested multiple computer-vision image classifiers, for their ability to identify a large set of common and rare pathogenic molds. Aim...
UNLABELLED: Fungiform papillae (FPs) are fundamental for taste perception, as they contain the taste sensory cells responsible for detecting taste sti...
PURPOSE: Voriconazole (VCZ) is a first-line treatment for invasive fungal disease, characterized by a narrow therapeutic window and significant inter-...
The application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal inf...
BACKGROUND: Superficial fungal infections are among the most common infections in world, they mainly affect skin, nails and scalp without further inva...