Gastroenterology

Latest AI and machine learning research in gastroenterology for healthcare professionals.

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Finetuning Foundation Models for Temporal Clinical Transcriptomics Data

Timeseries clinical transcriptomic datasets offer the opportunity to gain insights into the dynamics...

The Regional Landscape of the Human Colon Culturome in Health and Cystic Fibrosis

Cystic fibrosis (CF) alters gut physiology, yet its impact on microbial communities across colonic r...

Enhancing Medical Image Segmentation through Negative Sample Integration: A Study on Kvasir-SEG and Augmented Datasets

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with early an...

Gut Microbiota Modulates and Predicts Disease Severity in Experimental Pemphigoid Disease

Pemphigoid diseases (PD) are autoimmune blistering diseases with reported alterations in skin and gu...

Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is a major cause of drug attrition and poses a significant threat t...

Single-cell RNA sequencing and large-scale bulk combination with machine learning reveal gastric cancer-related macrophage heterogeneity

The tumor microenvironment (TME) significantly impacts cancer progression and overall patient surviv...

A large language model for predicting pancreatic ductal adenocarcinoma patients from blood-derived exosomal transcriptomics data

Traditional machine learning approaches for text or sequence classification rely on converting textu...

Integrative transcriptomic analysis identifies miR-642a-5p as a regulator of POFUT1 expression in colon cancer

Colorectal cancer (CRC) is one of the most common and deadly cancers worldwide, underscoring the urg...

Viral protease-Initiated Pyroptosis Activator mRNA therapy as a Universal Antiviral Strategy

Although therapeutic drugs targeting gasdermin (GSDM)-mediated pyroptosis have made remarkable progr...

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

The Spatial Atlas of Human Anatomy (SAHA) represents the first multimodal, subcellular- resolution r...

A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

Esophageal squamous cell carcinoma (ESCC) is a disease with limited tools for early screening and a ...

Batch-Harmonized Machine Learning Framework for Cross-Cohort RNA Biomarker Discovery in Pancreatic Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) lacks reliable prognostic biomarkers. RNA-based signatures s...

Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

Cells must adopt flexible regulatory strategies to make decisions regarding their fate, including di...

Inhibitory cell type heterogeneity in a spatially structured mean-field model of V1

Inhibitory interneurons in the cortex are classified into cell types differing in their morphology, ...

Revealing the Paper Mill Iceberg: AI-Based Screening of Cancer Research Publications

To train and validate a machine learning model to distinguish paper mill publications from genuine c...

Unraveling miRNA-Driven DNA Damage Response Networks in Pancreatic Adenocarcinoma: A Multi-Omics and Machine Learning Approach

Due to the late detection, aggressive nature, and paucity of treatment options, pancreatic adenocarc...

Colon-Specific Epigenetic Clocks from Minimal Features Reveal Disease-Driven Aging

Epigenetic clocks estimate chronological and biological age from DNA methylation patterns, but conve...

TRIO-AI: Hybrid temporal graph, ODE, and VAE modeling for high-resolution cellular trajectory inference in liver injury

Resolving dynamic cellular transitions at single-cell resolution is essential for understanding comp...

MetaPaCS: A Novel Meta-Learning Framework for Pancreatic Cancer Subtype Identification

As the third leading cause of cancer related deaths in the United States, pancreatic cancer (PaC) is...

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