Gastroenterology

Assessing the suitability of automated registration and segmentation for dosimetry calculations in SIRT treatment planning.

BACKGROUND: Selective internal radiation therapy (SIRT) increasingly relies on accurate magnetic resonance imaging (MRI) to computed tomography (CT) registration and accurate liver and tumour segmentation, for effective pre-treatment planning. This study evaluates the impact of automatic registration and segmentation techniques on dosimetry calculations for SIRT treatment planning. It compares sem...

DNA methylation biomarkers associated with early gastric cardia carcinogenesis.

Gastric cardia cancer (GCC) is an aggressive malignancy with poor prognosis, underscoring the need for better characterization of molecular alterations during early gastric cardia carcinogenesis. This study aimed to identify and validate tissue-based DNA methylation markers associated with early precancerous and neoplastic lesions of the gastric cardia. We integrated genome-wide DNA methylation da...

Predictors of the Efficacy of Focused Ultrasound for Moderate-to-Severe Persistent Allergic Rhinitis: A Retrospective Cohort Study.

BACKGROUND: Focused ultrasound (FUS) has achieved favorable results in the treatment of allergic rhinitis (AR). However, some patients still have poor...

Distilling Knowledge in Gastroenterology: An Artificial Intelligence System for Assisting Colonoscopy and Pathology Report Review.

OBJECTIVE: To develop an efficient and domain-adapted system to process colonoscopy and pathology reports using knowledge distillation techniques. PAT...

Photoacoustic-ultrasound endoscopy for assessment of rectal cancer treatment response: A prospective study with T2-weighted MRI radiomics comparison.

Accurate identification of pathological complete response (pCR) following neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC) is c...

Early Risk Stratification for Mechanical Ventilation in Acute Ischemic Stroke: Development and Validation of a Simplified Clinical Score.

Background and PurposeMechanical ventilation (MV) occurs in a substantial subset of acute ischemic stroke (AIS) hospitalizations and is associated wit...

Prediction Model for Delirium in Patients with Sepsis-Associated Liver Injury: An Interpretable Machine Learning Approach.

BackgroundPatients with sepsis-associated liver injury (SALI) are at marked risk of delirium, a severe complication strongly linked with poor neurolog...

Integrative multi-omics analysis identifies a core ferroptosis signature and validates resveratrol as a novel inducer in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to treatment resistance and an immunosuppressive, fibrotic microenvironment. Ferrop...

Prognostic Significance and Therapeutic Implications of Migrasome-related genes in Sorafenib Treatment for Primary Liver Cancer.

PURPOSE: This study aimed to reveal the mechanism and prognostic significance of migrasome-related genes (MGs) in primary liver cancer (PLC) treated w...

Integrated single-cell and bulk transcriptomic analyses unveil a necroptosis-related prognostic model and its association with tumor microenvironment remodeling in gastric cancer.

BACKGROUND: Necroptosis has emerged as a critical regulator in tumor progression and therapeutic response, yet its prognostic significance and influen...

Ultrasound-guided robotic percutaneous puncture for liver tumors with respiratory gating via attention-enhanced Siamese networks.

BACKGROUND AND OBJECTIVE: Accurate and safe needle insertion is critical in abdominal percutaneous interventions, particularly for liver-targeted proc...

The retinol metabolizing enzyme DHRS3 coordinates antigen presentation, endothelial stability, and cholesterol metabolism to suppress hepatocellular carcinoma progression.

Hepatocellular carcinoma (HCC) remains a therapeutic challenge due to tumor microenvironment heterogeneity and metabolic reprogramming. DHRS3, a retin...

MRI Habitat Analysis for Preoperative Prediction of Perineural Invasion and Prognostic Stratification in Rectal Cancer.

BACKGROUND: Accurate preoperative assessment of perineural invasion (PNI) remains challenging in rectal cancer. PURPOSE: To develop assessment models ...

Editorial for "MRI Habitat Analysis for Preoperative Prediction of Perineural Invasion and Prognostic Stratification in Rectal Cancer".

Integrating spatial and single-cell transcriptomics via machine learning to characterize efferocytosis in hepatocellular carcinoma prognosis and immunotherapy.

BACKGROUND: The intratumoral heterogeneity and immunosuppressive microenvironment of hepatocellular carcinoma (HCC) significantly limit therapeutic ef...

NucVerse3D: generalizable 3D nuclear instance segmentation across heterogeneous microscopy modalities.

Accurate three-dimensional (3D) nuclear instance segmentation is a prerequisite for quantitative phenotyping in volumetric microscopy, yet remains cha...

Artificial intelligence iterative imaging reconstruction with low-dose CT scans for hepatic metastases.

Contrast-enhanced CT is commonly used in the evaluation of hepatic metastatic lesions. This prospective study aimed to assess the capability of artifi...

Construction of a predictive model for the risk of non-alcoholic fatty liver disease in patients with sleep apnea syndrome based on multiple machine learning algorithms: a multicenter study.

BACKGROUND: Sleep apnea syndrome (SAS) is closely related to an increased risk of non-alcoholic fatty liver disease (NAFLD), but current clinical tool...

Preoperative prediction of hepatocellular carcinoma histological grade using MRI-based artificial intelligence models: A systematic review and meta-analysis.

OBJECTIVE: To evaluate the diagnostic performance of magnetic resonance imaging (MRI)-based artificial intelligence (AI) models in preoperatively pred...

The dynamics of hepatitis B transmission with treatment and vaccination: A case study in the Ili Region of Xinjiang, China, by a physics-informed neural networks approach.

Hepatitis B virus (HBV) infection remains a leading cause of cirrhosis and hepatocellular carcinoma worldwide, and long-term control relies on sustain...