Latest AI and machine learning research in genetics for healthcare professionals.
Candida auris, an increasingly prevalent fungal pathogen, requires both rapid identification and antifungal susceptibility testing to enable proper treatment. This study introduces digital SHERLOCK (dSHERLOCK), a platform that combines CRISPR/Cas nucleic acid detection, single-template quantification and real-time kinetics monitoring. Assays implemented on this platform display excellent sensitivi...
BACKGROUND: Approximately half of all high-grade serous ovarian carcinomas (HGSCs) have a therapeutically targetable defect in homologous recombination (HR) DNA repair. While there are genomic and transcriptomic methods, developed for other cancers, to identify HR deficient (HRD) samples, there are no gene expression-based tools to predict HR status in HGSC specifically. We have built a HGSC-speci...
Massively parallel genetic screens have been used to map sequence-to-function relationships for a variety of genetic elements1-5. However, as these ap...
BACKGROUND: Cancer-associated fibroblasts (CAFs) are key players in the tumor microenvironment (TME), but their roles in prognosis and immunotherapy r...
Alfalfa (Medicago sativa L.) is a critical forage crop whose improvement depends on resolving the complex genetic architecture of agronomic traits. Wh...
The increasing availability of multi-omics data is promising in enhancing genomic prediction in breeding and human genetics. However, integrating mult...
MOTIVATION: Drug synergy is crucial for developing effective combination therapies, but traditional screening methods suffer from inefficiency and hig...
Cas9 nucleases defend bacteria against invading DNA and can be used with single guide RNAs (sgRNAs) as antimicrobials and genome-editing tools. Howeve...
The rapid development of multimodal large language models (LLMs) such as GPT and Med-PaLM is reshaping medical practice. Skin cancer, one of the most ...
Lung-cancer-on-a-chip (LCOC) technologies have advanced rapidly, yet most models evaluate mechanical strain, patient-derived tumors, multi-organ inter...
Cis-regulatory elements (CREs) are key determinants of gene expression underlying complex agronomic traits. However, accurately identifying CREs in cr...
BACKGROUND AND AIMS: Ulcerative colitis (UC), a chronic inflammatory bowel disease, causes persistent mucosal inflammation and epithelial dysfunction....
To uncover novel genetic factors required for Listeria monocytogenes cell infection, we developed an automated high-throughput microscopy screening pi...
BACKGROUND: Glioma is the most common malignant primary brain tumor. Temozolomide (TMZ) is the standard first-line chemotherapy, but its efficacy is s...
Chimeric antigen receptor T-cell (CAR-T) therapy has achieved unprecedented success in hematological malignancies but faces formidable challenges in s...
Vascular dementia (VaD) is the second most common type of dementia, yet its pathogenesis is not fully understood, and effective diagnostic and therape...
Prostate cancer, among the most prevalent cancer types globally, exhibits marked heterogeneity and varying disease progression and clinical outcomes. ...
Neurogenomics has provided exceptional insights into the genetic architecture underlying autism spectrum disorder (ASD), which is increasingly underst...
Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield a...
Baijiu aroma is governed by a small number of odor-active compounds present at trace or ultra-trace levels, whose formation and perception are shaped ...