Genetics

Investigating the paternal genetic structure and migration history of Chinese Qiang minority by Y-chromosome short tandem repeats.

Known for its legendary history and peculiar culture, Chinese Qiang minority aroused interest among geneticists and anthropologists. However, the paternal genetic landscape of its sub-branches coupled with its migration history has never been uncovered. In this study, 37 Y-chromosomal short tandem repeat (Y-STR) loci of three Qiang ethnic groups ( = 564) were investigated to shed light on their pa...

Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm.

BackgroundNon-invasive methods with universal prognostic guidance for detecting breast cancer (BC) survival biomarkers need to be further explored.ObjectiveThis study aimed to investigate C-C motif chemokine receptor type 5 (CCR5) prognosis value in BC and develop a radiomics model for noninvasive prediction of CCR5 expression in BC.MethodsA total of 840 cases with genomic information were include...

A pathway-informed disease-related gene identification approach and its application to screen novel risk genes for Alzheimer's disease.

BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disorder, yet its molecular mechanisms remain incompletely understood. It is known ...

Imaging patterns and recommendations for diagnosis, staging, and management of lung cancer.

Lung cancer is the second most commonly diagnosed cancer worldwide. In the present era of targeted therapy for various lung cancer mutations, it is es...

Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity.

Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show that the gut microbiota influences and is influenced...

Genomics-assisted breeding for designing salinity-smart future crops.

Climate change induces many abiotic stresses, including soil salinity, significantly challenging global agriculture. Salinity stress tolerance (SST) i...

Transforming healthcare: the impact of artificial intelligence on diagnostics, pharmaceuticals and ethical considerations - a comprehensive review.

Interpretability of results remains challenging in most health industries since patients may suffer life-threatening consequences from an inaccurate d...

XVir: A Transformer-Based Architecture for Identifying Viral Reads from Cancer Samples.

It is estimated that approximately 15% of cancers worldwide can be linked to viral infections. The viruses that can cause or increase the risk of canc...

An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samples.

Circulating tumor DNA is a critical biomarker in cancer diagnostics, but its accurate interpretation requires careful consideration of clonal hematopo...

CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.

The large-scale application of the mammalian methylation array has substantially expanded the availability of DNA methylation data in mammalian specie...

Integrating Artificial Intelligence and Precision Therapeutics for Advancing the Diagnosis and Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex molecular mechanisms, including genetic susceptibilit...

Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer.

BACKGROUND: Ovarian cancer (OC), a common fatal malignancy in women, has a poor prognosis. RNA modifications are associated with the development of OC...

Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein.

Cytoskeletal motor protein dynein belongs to the AAA+ superfamily of enzymes, functioning as a mechanochemical ATPase that converts chemical energy in...

Non-invasive CT based multiregional radiomics for predicting pathologic complete response to preoperative neoadjuvant chemoimmunotherapy in non-small cell lung cancer.

PURPOSE: This study aims to develop and validate a multiregional radiomics model to predict pathological complete response (pCR) to neoadjuvant chemoi...

Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder influenced by genetic, epigenetic, and environmental factors. ASD is character...

The Future of Parasomnias.

Parasomnias are abnormal behaviours or mental experiences during sleep or the sleep-wake transition. As disorders of arousal (DOA) or REM sleep behavi...

Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib.

OBJECTIVE: Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is ma...

Novel marker genes and small molecule drugs for radiotherapy resistance in cervical cancer identified based on single-cell multi-omics analysis.

Radiotherapy is the cornerstone of treatment for cervical cancer, yet the variability of patient response demands a deeper understanding of the molecu...

Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma.

BACKGROUND: Epithelial ovarian cancer (EOC) is a deadly and heterogenous disease comprising five major histotypes: clear cell carcinoma (CCC), endomet...

Mpox diagnosis at POC.

The increasing number of Monkeypox (Mpox) cases in non-endemic countries resulted in the WHO declaring a public health emergency of international conc...