Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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High-throughput label-free detection of DNA-to-RNA transcription inhibition using brightfield microscopy and deep neural networks.

Drug discovery is in constant evolution and major advances have led to the development of in vitro h...

Apr 2021 33845268
Machine Learning-Based Multiparametric Magnetic Resonance Imaging Radiomics for Prediction of H3K27M Mutation in Midline Gliomas.

OBJECTIVE: H3K27M mutation in gliomas has prognostic implications. Previous magnetic resonance imagi...

Apr 2021 33819703
HARVESTMAN: a framework for hierarchical feature learning and selection from whole genome sequencing data.

BACKGROUND: Supervised learning from high-throughput sequencing data presents many challenges. For o...

Apr 2021 33794760
Classification and Design of HIV-1 Integrase Inhibitors Based on Machine Learning.

A key enzyme in human immunodeficiency virus type 1 (HIV-1) life cycle, integrase (IN) aids the inte...

Apr 2021 33868450
A novel based-performance degradation indicator RUL prediction model and its application in rolling bearing.

Aiming at the problem of poor prediction performance of rolling bearing remaining useful life (RUL) ...

Mar 2021 33845998
A novel end-to-end method to predict RNA secondary structure profile based on bidirectional LSTM and residual neural network.

BACKGROUND: Studies have shown that RNA secondary structure, a planar structure formed by paired bas...

Mar 2021 33789581
Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.

We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection a...

Mar 2021 33788842
Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning.

Drug resistance threatens many critical therapeutics through mutations in the drug target. The molec...

Mar 2021 33783217
Machine learning is the key to diagnose COVID-19: a proof-of-concept study.

The reverse transcription-polymerase chain reaction (RT-PCR) assay is the accepted standard for coro...

Mar 2021 33785852
Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease.

Observing Alzheimer's disease (AD) pathological changes in vivo with neuroimaging provides invaluabl...

Mar 2021 33782864
Automated optimization of double heater convective polymerase chain reaction devices based on CFD simulation database and artificial neural network model.

This paper presents a framework for automated optimization of double-heater convective PCR (DH-cPCR)...

Mar 2021 33782743
Using the antibody-antigen binding interface to train image-based deep neural networks for antibody-epitope classification.

High-throughput B-cell sequencing has opened up new avenues for investigating complex mechanisms und...

Mar 2021 33780441
Epigenetic Target Fishing with Accurate Machine Learning Models.

Epigenetic targets are of significant importance in drug discovery research, as demonstrated by the ...

Mar 2021 33770434
Machine Learning Reduced Gene/Non-Coding RNA Features That Classify Schizophrenia Patients Accurately and Highlight Insightful Gene Clusters.

RNA-seq has been a powerful method to detect the differentially expressed genes/long non-coding RNAs...

Mar 2021 33805976
Two novel potent ACEI peptides isolated from meat hydrolysates using analysis: identification, screening and inhibitory mechanisms.

The aim of this study was to discover potent angiotensin-converting enzyme (ACE) inhibitory (ACEI) p...

Mar 2021 35423777
Evaluation of supervised machine-learning methods for predicting appearance traits from DNA.

The prediction of human externally visible characteristics (EVCs) based solely on DNA information ha...

Mar 2021 33831816
Disentangling the Contribution of Each Descriptive Characteristic of Every Single Mutation to Its Functional Effects.

Mutational effects predictions continue to improve in accuracy as advanced artificial intelligence (...

Mar 2021 33754712
Machine learning-based reclassification of germline variants of unknown significance: The RENOVO algorithm.

The increasing scope of genetic testing allowed by next-generation sequencing (NGS) dramatically inc...

Mar 2021 33761318
Experimental support for genomic prediction of climate maladaptation using the machine learning approach Gradient Forests.

Gradient Forests (GF) is a machine learning algorithm that is gaining in popularity for studying the...

Mar 2021 33683822
Raman spectroscopy and artificial intelligence to predict the Bayesian probability of breast cancer.

This study addresses the core issue facing a surgical team during breast cancer surgery: quantitativ...

Mar 2021 33753760
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