Genetics

A noninvasive urinary microRNA-based assay for early detection of lung cancer and its potential application to prognosis and recurrence monitoring: a case-control study.

Lung cancer remains the leading cause of cancer-related mortality worldwide, with recurrence or canc...

Machine learning-based models for tumor mutation burden prediction in gastrointestinal cancers: a systematic review and meta-analysis.

The B7 family subgroup reflects tumor cell heterogeneity and patient post-operative prognosis in gallbladder cancer.

PURPOSE: To elucidate the biological heterogeneity of gallbladder cancer (GBC) cells and refine post...

[Advances in oral and craniofacial bone regeneration modulated by stem cells and biomaterials].

Cranio-maxillofacial bone defects resulting from trauma, tumors, infection, or congenital malformati...

Identifying neuroimaging-based biomarkers for obsessive-compulsive disorder: A resting-state fMRI and machine learning study in patients and unaffected first-degree relatives.

BACKGROUND: Identifying whether brain alterations in obsessive-compulsive disorder (OCD) represent t...

BloomSight: An ultra-high-frequency phenotyping framework for diurnal flowering dynamics in japonica and indica rice to enable genetic dissection and hybrid-breeding applications.

Rice (Oryza sativa) production underpins food security in many rice-consuming nations. As a critical...

Novel therapeutic strategies for metastatic castration‑resistant prostate cancer: Beyond androgen receptor pathway inhibition (Review).

Metastatic castration‑resistant prostate cancer (mCRPC) remains a lethal disease due to universal re...

Predicting protein-nucleic acid interactions via protein language models with biophysical and evolutionary priors.

Protein interactions with nucleic acids are fundamental to numerous biological processes. Here, we p...

A network-based deep learning model integrating subclonal architecture for therapy response prediction in cancer.

Predicting treatment response remains challenging in oncology, particularly given the growing divers...

Unlocking non-model organisms with CRISPR-Cas: A roadmap for sustainable biotechnology.

The reliance on model organisms in biotechnology has advanced our understanding of fundamental biolo...

Examining Genetic Variants Associated with FOXP1 Syndrome through Molecular Dynamics of Its DNA-Binding Domain and Self-Organizing Maps.

Genetic mutations in the transcription factor FOXP1 (forkhead box protein P1) cause an autosomal dom...

Advances in HLA and Non-HLA Immune Profiling: Integrating Next-Generation Sequencing and Artificial Intelligence in Transplantation.

Understanding transplantation outcomes requires an integrated view of immunological, genetic, and cl...

Leveraging long-read assemblies and machine learning to enhance short-read transposable element detection and genotyping.

Transposable elements (TEs) are parasitic genomic elements that are ubiquitous across the tree of li...

Integrating Sperm Microscopy, Environmental Exposures, and Lifestyle Factors for Male Fertility Analysis: Protocol for the Nippon Semen and Environmental Exposure Database (N-SEED) Cross-Sectional Study.

BACKGROUND: Conventional semen analysis does not fully capture male reproductive potential. The sper...

Tools and tactics for studying alternative splicing.

Alternative splicing generates transcriptomic diversity essential for cellular homeostasis, and its ...

A Reinforcement Learning-Guided Genetic Algorithm Integrating Medicinal Chemistry-Inspired Molecular Transformations.

Achieving optimal target activity while maintaining synthetic accessibility and drug-likeness repres...

Small RNAs as systemic signals in plant defense: mechanisms, challenges, and future directions.

Small RNAs (sRNAs) have emerged as central regulators of gene expression, coordinating development, ...

Bridging In Silico Design and Experimental Validation: Virtual Screening and In Vitro Assessment of Biomimetic Anticancer Peptides Inspired by Horseshoe Crab Hemolymph Proteins.

BACKGROUND: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, necessitati...

SaintGSE: Transformer-based efficient and explainable gene set enrichment analysis.

OBJECTIVE: Gene set enrichment analysis (GSEA) is widely used to interpret genome-wide expression da...

An ensemble pipeline, PhageHost, for phage tail fiber discovery and accurate Klebsiella pneumoniae host prediction using protein language models.

The high specificity of phages toward their hosts holds great promise for phage therapy while posing...

In silico virtual knockout identifies PXDNL as a fibroblast-specific driver of sarcopenia and GABA as a potential modulator.

Sarcopenia lacks causal mechanisms and translatable targets. We integrated virtual gene knockout wit...