Latest AI and machine learning research in genetics for healthcare professionals.
The CRISPR/Cas system has emerged as a transformative tool for nucleic acid detection, offering significant potential for point-of-care testing (POCT). However, translating CRISPR/Cas-based assays into practical POCT devices critically depends on the development of portable, sensitive, and user-friendly signal readout modalities. This review systematically compares four major readout modalities: f...
In genome-scale constraint-based metabolic models, gene deletion strategies are essential for achieving growth-coupled production, where cell growth and target metabolite synthesis occur simultaneously. Despite the inherently networked nature of genome-scale metabolic models, existing computational approaches rely primarily on sequential data and lack graph representations that capture their compl...
Common genetic variants contribute to risk for complex human diseases. However, despite thousands of associations, variants modulating disease risk an...
BACKGROUND: With growing interest in ART, fertility preservation, and postmenopausal health of women, reproductive medicine is increasingly focused on...
Late distant recurrence (DR) remains a persistent risk in hormone receptor-positive (HR+) early breast cancer after completion of 5 years of endocrine...
BACKGROUND: Ovarian cancer (OVCA) is a common and highly aggressive gynecologic malignancy often diagnosed at advanced stages. Approximately 30% of pa...
Protein-RNA interactions (RPIs) stand for the central process in post-transcriptional regulation and have catalyzed a fast proliferation of computatio...
INTRODUCTION: Rice panicle development is a key agronomic trait that critically determining grain yield and quality. However, the underlying molecular...
Estrogen receptor 1 (ESR1) is an established oncogenic transcription factor in breast and endometrial cancer; however, more is known about the mechani...
INTRODUCTION: The National Dyslipidemia Registry of the Spanish Atherosclerosis Society (SEA) represents a major source of real-world evidence on lipi...
Yellow rust (YR) is a major threat to both bread and durum wheat production, often causing substantial yield losses. Conventional visual scoring of YR...
The future of pediatric gene therapy is being fundamentally reshaped by the convergence of CRISPR-Cas9 genome editing, artificial intelligence (AI), a...
PURPOSE: Autophagy is increasingly recognized as a promising therapeutic target in prostate cancer (PCa), yet its research landscape has not been syst...
A mechanistic understanding of how genetic variants alter drug-receptor binding is central to precision medicine, drug response prediction, and drug d...
BACKGROUND: Diabetic kidney disease (DKD) is the primary global cause of end-stage renal disease. However, the aging-related gene networks driving its...
Cortical layer 1 plays an essential role in neural networks, integrating many streams of information and undergoing plasticity during learning. Yet, w...
BACKGROUND: Heart failure (HF) is the terminal stage of cardiovascular disease with high global prevalence and poor prognosis. This study aimed to ide...
The genomic deluge has pushed viral molecular evolution into a site-resolved era. For antigenically evolving viruses such as influenza and severe acut...
The escalating threat of viral pandemics, dramatically illustrated by the COVID-19 crisis, has exposed the critical shortcomings of conventional react...