Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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[Progress in neoadjuvant immunotherapy for locally advanced rectal cancer].

Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for locally advanced rectal cancer (...

Jun 2025 40550665
Harnessing advances in mechanisms, detection, and strategies to combat antimicrobial resistance.

Antimicrobial resistance (AMR) is a growing global health crisis, threatening the effectiveness of a...

Jun 2025 40373688
Fetal growth disorders detection during first trimester gestation through comprehensive maternal circulating DNA profiling.

BACKGROUND: Early diagnosis, close follow-up and timely delivery constitute the main elements for ap...

Jun 2025 40263746
Widespread false negatives in DNA-encoded library data: how linker effects impair machine learning-based lead prediction.

DNA-encoded chemical libraries (DECLs) have become integral to early-stage drug discovery, yielding ...

Jun 2025 40395382
Quantitative and qualitative metrics of tumor stroma in predicting ovarian cancer outcomes and expansion of its study with AI-based tools.

Epithelial ovarian cancer remains one of the deadliest gynecologic malignancies, with late-stage dia...

Jun 2025 40524858
Microbial dysbiosis and its diagnostic potential in androgenetic alopecia: insights from multi-kingdom sequencing and machine learning.

Androgenetic alopecia (AGA), the most common form of hair loss, has been linked to dysbiosis of the ...

Jun 2025 40434156
Kolmogorov-Arnold Network for Gene Regulatory Network Inference

Gene regulation is central to understanding cellular processes and development, potentially leadin...

Curriculum Learning for Biological Sequence Prediction: The Case of De Novo Peptide Sequencing

Peptide sequencing-the process of identifying amino acid sequences from mass spectrometry data-is ...

LapDDPM: A Conditional Graph Diffusion Model for scRNA-seq Generation with Spectral Adversarial Perturbations

Generating high-fidelity and biologically plausible synthetic single-cell RNA sequencing (scRNA-se...

A Memetic Walrus Algorithm with Expert-guided Strategy for Adaptive Curriculum Sequencing

Adaptive Curriculum Sequencing (ACS) is essential for personalized online learning, yet current ap...

Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy.

RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precis...

Jun 2025 40354673
Improving spliced alignment by modeling splice sites with deep learning

Motivation: Spliced alignment refers to the alignment of messenger RNA (mRNA) or protein sequences...

DuoFormer: Leveraging Hierarchical Representations by Local and Global Attention Vision Transformer

Despite the widespread adoption of transformers in medical applications, the exploration of multi-...

ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network.

With the rise of small interfering RNA (siRNA) as a therapeutic tool, effective siRNA design is cruc...

Jun 2025 40194620
Discovery of naturally inspired antimicrobial peptides using deep learning.

Non-ribosomal peptides (NRPs) are promising lead compounds for novel antibiotics. Bioinformatic mini...

Jun 2025 40209356
Component Based Quantum Machine Learning Explainability

Explainable ML algorithms are designed to provide transparency and insight into their decision-mak...

Network Pharmacology Reveals HSPA1A/BST2 as Potential Targets of Ci Bai Capsule's Active Compounds Intervening in Leukopenia

Background: Radiation-induced leukopenia caused by low-dose exposure is frequently associated with...

Development and experimental verification of a prognosis model for hypoxia- and lactate metabolism-associated genes in HNSCC.

Hypoxia and lactate metabolism are both distinctive characteristics of cancerous cells. Head and nec...

Jun 2025 40527790
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