Latest AI and machine learning research in genetics for healthcare professionals.
Prime editing has rapidly emerged as a versatile and precise genome engineering technology capable of introducing targeted substitutions, insertions, and deletions without requiring double-strand breaks or donor DNA templates. Since its initial development, substantial progress has been achieved through iterative innovations in core components, including Cas protein variants, reverse transcriptase...
BACKGROUND: The UK reports approximately 2000 imported malaria cases annually, necessitating effective surveillance to determine infection sources and transmission routes, inform strategies for prevention and detect molecular markers of drug resistance that may compromise treatment outcomes. Defined by their unclear route of infection, cryptic malaria cases pose a particular challenge for malaria ...
Accurate identification of enhancer sequences requires concurrent modeling of global contextual information and local regulatory motifs in DNA. Althou...
Despite the groundbreaking advances in deep learning-enabled methods for biomolecular modeling, predicting accurate three-dimensional (3D) structures ...
BACKGROUND: Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, plays a pivotal role in chondrocyte death and the...
INTRODUCTION: Clinical management of RAS wild-type colorectal cancer liver metastases (CRLM) remains challenging because many patients exhibit primary...
INTRODUCTION: Osteoporosis (OP) is a multifactorial skeletal disorder marked by reduced bone mass and microstructural deterioration. We investigated p...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder leading to kidney failure. Recent advancements in arti...
Treatment resistance (TR) in major depressive disorder (MDD) affects a substantial minority of patients and is hard to recognize early, delaying inten...
Cellular heterogeneity underpins the complexity of human development and disease, as cells with the same genome exhibit distinct transcriptomic profil...
PURPOSE OF REVIEW: This paper examines several methods of technology that have challenged traditional expectations of the meaning of psychotherapy, fr...
Exercise is a promising strategy associated with improved cancer-related outcomes through multiple biological mechanisms. However, current exercise gu...
Long-read single-cell RNA sequencing enables full-length transcript profiling but remains limited by challenges in interpreting structurally complex s...
Erectile dysfunction (ED) is a prevalent complication of both type 1 and type 2 diabetes mellitus (DM), but the shared molecular mechanisms underlying...
BACKGROUND: ∼60%-70% of patients with metastatic non-small cell lung cancer (NSCLC) have relatively low tumor mutational burden (TMB), with limited bi...
The complex interdependence between cancer and diabetes has become a major subject of research in molecular medicine since multiple data points indica...
Hepatocellular carcinoma (HCC) treatment faces significant challenges, particularly in tumor growth, metastasis, and drug resistance. While several pr...
Artificial intelligence is rapidly transforming healthcare delivery. Over the past decade, studies have increasingly demonstrated that healthcare AI s...
Objective: To construct a machine learning diagnostic model for hereditary hearing loss based on GJB2 and SLC26A4 genes and perform interpretability a...
Bisphenol A (BPA), a ubiquitous environmental endocrine-disrupting chemical extensively used in plastic products, has been increasingly recognized for...