Genetics

A decoction-inspired genetic algorithm and PPO reinforcement learning for intelligent molecular discovery: Anti-colorectal cancer candidates from the tiao-pi AnChang formula.

BACKGROUND: Colorectal cancer (CRC) remains among the leading causes of cancer-related mortality wor...

HOW GENETICS CHANGED OR WILL CHANGE THE THERAPY IN THYROID NODULES WITH INDETERMINATE CYTOLOGY.

The incidence of thyroid cancer has risen in recent decades, largely due to the widespread use of in...

Meta-analysis, WGCNA, and machine learning converge on a four-gene biomarker panel for heat stress tolerance in Solanum lycopersicum.

Heat stress severely compromises growth, reproduction, and yield in Solanum lycopersicum, necessitat...

Generalist biological artificial intelligence in modeling the language of life.

Generalist biological artificial intelligence (GBAI) represents a transformative approach to modelin...

Statistical models to characterize colon tumor stiffness heterogeneity through representative atomic force microscopy maps.

The study of the impact of physical forces and on cells has emerged as a fertile field of investigat...

VEFill: accurate and generalizable deep mutational scanning score imputation across protein domains.

Deep Mutational Scanning (DMS) assays can systematically assess the effects of amino acid substituti...

A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.

Novel genomic risk stratification model for primary high-grade malignant peripheral nerve sheath tumor (MPNST).

Risk stratification across the three main clinical subsets of malignant peripheral nerve sheath tumo...

[Advances in integrated antimicrobial resistance diagnostics: quantitative, qualitative and AI-driven approaches].

The rapid global increase in antimicrobial resistance complicates the treatment of life-threatening ...

Readout of intrinsic and induced DNA shape by homeodomain transcription factor complexes.

Homeodomain transcription factors (TFs) recognize their DNA targets through both sequence-specific b...

Atypical Ductular Reactions Are a Distinct Regenerative Phenomenon in Hepatocellular Carcinoma (HCC) Patients after Transarterial Chemoembolization.

Transarterial chemoembolization (TACE) is increasingly used in patients with hepatocellular carcinom...

Integrated machine learning and multi-omics analysis identifies ALOX5 as a potential therapeutic target for tubulointerstitial inflammation in diabetic kidney disease.

Diabetic kidney disease (DKD) is a leading cause of renal failure. Inflammation of the renal tubules...

Bulliform cells: anatomical, physiological, genetic, and computational perspectives on plants' drought adaptation.

This work highlights pollen thermotolerance as vital for reproductive success under heat stress, int...

Active Learning-Guided Polymorph Control in Co-Precipitation Synthesis.

Phase control of polymorphic materials is important yet challenging due to the vast synthesis parame...

5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis.

BACKGROUND: Adenomyosis diagnosis and classification relies primarily on magnetic resonance imaging ...

Induced Dipole Calculation with E(3)-Equivariant Neural Networks and Multipole Field Perturbation.

Polarizable force fields based on induced dipoles are widely implemented in molecular dynamics simul...

DeepIM: Integrating Channel-Spatial Attention with Transformer for DNA i-Motif Folding Status Prediction.

i-Motif (iM), a quadruplex structure formed by C-rich DNA sequences under acidic conditions, is sign...

Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications.

INTRODUCTION: Alopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss...

Critical Assessment of a Structure-Based Pipeline for Targeting the Long Noncoding RNA MALAT1.

Long noncoding RNAs (lncRNAs) are increasingly recognized as druggable targets due to their conserve...

Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study.

BACKGROUND: Survival outcomes after transarterial chemoembolisation (TACE) vary in hepatocellular ca...

The ATF5-GPER1 axis drives female protection in hepatocellular carcinoma through dual tumor-suppressive and immune-modulatory mechanisms.

Hepatocellular carcinoma (HCC) exhibits marked sexual dimorphism, with females demonstrating superio...