Genetics

SMC4/SMAD3/NF-κB axis drives cervical cancer progression and radioresistance via DNA damage repair and immune modulation.

OBJECTIVE: Cervical cancer remains a significant global health burden, with the molecular determinan...

Resveratrol ameliorates sepsis-induced immune dysfunction by targeting GADD45A to maintain hematopoietic stem cell homeostasis: A predictive study integrating ensemble machine learning, single-cell transcriptomics, and molecular dynamics simulation.

OBJECTIVE: To investigate the potential pharmacological mechanisms of resveratrol (RES) in ameliorat...

High-Fidelity Data Retrieval from Synthetic DNA Pools via Machine Learning Model.

Synthetic DNA offers significant benefits, remarkable information density and long-term stability fo...

Dysbiosis of fecal virome in pediatric Crohn's disease and its dynamic changes during infliximab therapy.

UNLABELLED: The gut virome is an emerging but underexplored component of the human microbiota, espec...

Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay".

An Open-Source Pipeline for Calcium Imaging and All-Optical Physiology in Human Stem Cell-Derived Neurons.

High-throughput, single-cell resolution profiling of neuronal activity is critical for understanding...

DNA-Logic Trimodal Biofuel Cell Platform for AI-Assisted Dual Pathogen Detection.

A DNA-logic-gated, trimodal, self-powered biosensing platform is developed for the rapid, simultaneo...

The prevalence and clinical significance of clonal monocytosis.

The terms clonal monocytosis of undetermined significance (CMUS) and clonal cytopenia and monocytosi...

Epitranscriptomic signatures of malignancy: how RNA modifications shape breast and ovarian tumor progression.

Breast and ovarian cancers are still one of the most prevalent causes of cancer death among the wome...

GenX-associated molecular signatures overlap with testicular aging and male infertility: a multi-omics integration analysis.

GenX (HFPO-DA), a short-chain per- and polyfluoroalkyl substance (PFAS) substitute, is implicated in...

IMMT downregulation promotes osteoarthritis development by inducing mitochondrial dysfunction.

OBJECTIVE: This study aimed to identify key mitochondria-related genes involved in the pathogenesis ...

Application of untargeted plasma metabolomics and machine learning to construct a diagnostic model for hypertrophic cardiomyopathy: a case-control study.

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease. R...

Harnessing bacterial power and omics technologies for sustainable plastic waste biodegradation.

Plastic pollution constitutes a critical environmental concern of this era, with synthetic polymers,...

6PPD-quinone promotes ovarian cancer progression: Insights from network toxicology, machine learning, and in vitro validation.

6PPD-quinone (6PPD-Q), a toxic tire-derived antioxidant transformation product, is a pervasive envir...

Integrating single-cell atlases and machine learning to construct 'in silico patients' for predicting individualized drug responses.

Intratumoral cellular heterogeneity is a core challenge that drives drug resistance and hinders the ...

CRISPR-Cas12a/Cas13a in cancer molecular diagnosis.

Cancer remains a leading cause of global mortality, with early diagnosis being pivotal for improving...

Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review).

Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease characterized by irreve...

Proteogenomic characterization delineates clinically relevant subtypes of advanced differentiated thyroid cancer.

Advanced differentiated thyroid cancer (DTC) is characterized by limited therapeutic options and unf...

The association between psychotropic medications and cognitive functioning in bipolar disorder.

BACKGROUND: Many individuals with bipolar disorder have decreased levels of cognitive functioning ev...

From pharmacokinetic genes to polygenic scores and multi-omic integration: advances towards precision psychiatry.

INTRODUCTION: . Pharmacological treatment is the mainstay in the acute and long-term management of s...

Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI).

BACKGROUND: Early detection of cancer and precise recurrence monitoring remain major unmet needs in ...