Geriatrics

Latest AI and machine learning research in geriatrics for healthcare professionals.

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Linguistic Indicators of Early Cognitive Decline in the DementiaBank Pitt Corpus: A Statistical and Machine Learning Study

Background: Subtle changes in spontaneous language production are among the earliest indicators of c...

AI System Using Unsupervised Learning to Discover Novel Subtypes in Alzheimer's Disease

Early Alzheimer's disease often evades timely detection because typical diagnostics are based on sym...

AD$^2$: Analysis and Detection of Adversarial Threats in Visual Perception for End-to-End Autonomous Driving Systems

End-to-end autonomous driving systems have achieved significant progress, yet their adversarial robu...

Comp2Comp: Open-Source Software with FDA-Cleared Artificial Intelligence Algorithms for Computed Tomography Image Analysis

Artificial intelligence allows automatic extraction of imaging biomarkers from already-acquired radi...

GRAD: A Two-Stage Algorithm for Resolving Diagnostic Uncertainty in the Plasma p-tau217 Gray Zone

Introduction: Plasma phosphorylated tau-217 is widely used as a plasma-based biomarker for Alzheimer...

α-Synuclein Strain Dynamics Correlate with Cognitive Shifts in Parkinson's Disease

-Synuclein (-syn) strains can serve as discriminators between Parkinson's disease (PD) and related -...

Multimodal normative modeling in Alzheimers Disease with introspective variational autoencoders

Normative modeling learns a healthy reference distribution and quantifies subject-specific deviation...

The hippocampus as a small-world cognitive map

When a mouse perceives a hawk's shadow, it may have only seconds to decide where to run, yet the saf...

Altered Baseline Brain Network Topology in High-Risk Individuals Progressing to Mild Cognitive Impairment

Background: Identifying early brain-based markers of cognitive decline is critical for preventive st...

SPARC: Separating Perception And Reasoning Circuits for Test-time Scaling of VLMs

Despite recent successes, test-time scaling - i.e., dynamically expanding the token budget during in...

Adaptive-CaRe: Adaptive Causal Regularization for Robust Outcome Prediction

Accurate prediction of outcomes is crucial for clinical decision-making and personalized patient car...

CytoCrowd: A Multi-Annotator Benchmark Dataset for Cytology Image Analysis

High-quality annotated datasets are crucial for advancing machine learning in medical image analysis...

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer's disease

Aging and genetic risk shape the molecular programs that confer cellular vulnerability in Alzheimer'...

Model-Driven Hybrid AI Framework for End-to-End Autonomous Decision-Making in Drug Development

Decision-making in drug development spans heterogeneous stages from molecular design to clinical opt...

A Mixed Reality System for Robust Manikin Localization in Childbirth Training

Opportunities for medical students to gain practical experience in vaginal births are increasingly c...

Selectively Augmented Decision Tree for Explainable Dementia Detection

Timely and accurate diagnosis of dementia remains a critical yet challenging task. Although machine ...

APOE ε4 defines a systemic immune endophenotype independent of clinical trajectory in amyotrophic lateral sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is clinically heterogeneous, and genetic modifiers m...

ExSEnt for explainable dementia detection: disentangling temporal and amplitude-driven complexity boosts EEG-based classification

Early detection of dementia enables timely intervention and better care planning. Electroencephalogr...

G2DBridge: A Multimodal Framework Linking Genetics to Disease through Imaging Intermediates

Genetic-based risk prediction is becoming increasingly available for a wide range of common diseases...

Full end-to-end diagnostic workflow automation of 3D OCT via foundation model-driven AI for retinal diseases

Optical coherence tomography (OCT) has revolutionized retinal disease diagnosis with its high-resolu...

End-to-end reconstruction of OCT optical properties and speckle-reduced structural intensity via physics-based learning

Inverse scattering in optical coherence tomography (OCT) seeks to recover both structural images and...

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