Hematology

TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists.

Platelet activation is essential for hemostasis. Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2). CLEC-2 is a HemITAM (hem-immunoreceptor tyrosine activation motif)-bearing receptor that binds podoplanin and signals through spleen tyrosine kinase (Syk). T-cell ...

SmartHeLP: Smartphone-based Hemoglobin Level Prediction Using an Artificial Neural Network.

Blood hemoglobin level (Hgb) measurement has a vital role in the diagnosis, evaluation, and management of numerous diseases. We describe the use of smartphone video imaging and an artificial neural network (ANN) system to estimate Hgb levels non-invasively. We recorded 10 second-300 frame fingertip videos using a smartphone in 75 adults. Red, green, and blue pixel intensities were estimated for ea...

A Hybrid Residual Network and Long Short-Term Memory Method for Peptic Ulcer Bleeding Mortality Prediction.

The prediction of patient mortality, which can detect high-risk patients, is a significant yet challenging problem in medical informatics. Thanks to t...

Application of Machine Learning Methods to Predict Non-Alcoholic Steatohepatitis (NASH) in Non-Alcoholic Fatty Liver (NAFL) Patients.

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. NAFLD patients have excessive liver fat (steatosis)...

An Interpretable ICU Mortality Prediction Model Based on Logistic Regression and Recurrent Neural Networks with LSTM units.

Most existing studies used logistic regression to establish scoring systems to predict intensive care unit (ICU) mortality. Machine learning-based app...

Defining Massive Transfusion in Civilian Pediatric Trauma With Traumatic Brain Injury.

The purpose of this study was to identify an optimal definition of massive transfusion in civilian pediatric trauma with severe traumatic brain injury...

Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes.

BACKGROUND: Increased systemic and local inflammation play a vital role in the pathophysiology of acute coronary syndrome. This study aimed to assess ...

Design and Synthesis of Imidazo/Benzimidazo[1,2-]quinazoline Derivatives and Evaluation of Their Antimicrobial Activity.

A new class of fused quinazolines has been designed and synthesized via copper-catalyzed Ullmann type C-N coupling followed by intramolecular cross-de...

The feasibility of fingerstick blood collection for point-of-care HIV-1 viral load monitoring in rural Zambia.

Viral load monitoring for HIV treatment is recommended but not feasible in many settings. A point-of-care test using capillary blood would increase ac...

Deep-learned placental vessel segmentation for intraoperative video enhancement in fetoscopic surgery.

INTRODUCTION: Twin-to-twin transfusion syndrome (TTTS) is a potentially lethal condition that affects pregnancies in which twins share a single placen...

Prediction of findings at screening colonoscopy using a machine learning algorithm based on complete blood counts (ColonFlag).

Adenomatous polyps are a common precursor lesion for colorectal cancer. ColonFlag is a machine- learning-based algorithm that uses basic patient infor...

A Unique Case of Severe Anemia Secondary to Copper Deficiency in an Adult Patient.

Anemia is a frequently encountered problem in the healthcare system. Common causes of anemia include blood loss, followed by impaired red blood cell p...

A combined modelling of fuzzy logic and Time-Driven Activity-based Costing (TDABC) for hospital services costing under uncertainty.

Hospital traditional cost accounting systems have inherent limitations that restrict their usefulness for measuring the exact cost of healthcare servi...

Multi-Objective Genetic Algorithm Assisted by an Artificial Neural Network Metamodel for Shape Optimization of a Centrifugal Blood Pump.

A centrifugal blood pump is a common type of the pump used as a left ventricular assist device (LVAD) in the medical industries. The reduction of the ...

Blood Sugar Level Indication Through Chewing and Swallowing from Acoustic MEMS Sensor and Deep Learning Algorithm for Diabetic Management.

Diabetes, a metabolic disorder due to high blood glycemic index in the human body. The glycemic index varies in the human of improper diet and eating ...

Molecular prevalence of parvovirus B19 among HIV1-infected patients in Iran.

Different outcomes of parvovirus B19 (B19V) infection in immunocompromised patients, including HIV1-infected persons, may be life-threatening. Consid...

Antithrombotic Management during Percutaneous Mitral Valve Repair with the Mitraclip System in a Patient with Heparin-Induced Thrombocytopenia.

Interventional cardiology procedures require full anticoagulation to prevent thrombus formation on catheters and devices with potential development of...

Antimicrobial peptide based magnetic recognition elements and Au@Ag-GO SERS tags with stable internal standards: a three in one biosensor for isolation, discrimination and killing of multiple bacteria in whole blood.

In this study, a new biosensor based on a sandwich structure has been developed for the isolation and detection of multiple bacterial pathogens magne...

Different Expressions of Specific Transcription Factors of Th1 () and Th2 cells () by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis.

INTRODUCTION: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The ...

Radiofrequency endometrial ablation for treating heavy menstrual bleeding in women with chronic renal failure.

OBJECTIVE: The study objective was to retrospectively evaluate the efficacy and safety of radiofrequency endometrial ablation in treating heavy menstr...