Hematology

Fates of algal and natural organic matters during moderate pre-oxidation of potassium permanganate composite to enhance coagulation of algae-laden water.

Pre-oxidation has been increasingly applied to enhance coagulation during algae-laden water treatment, yet the transformation behaviors of algal organic matter (AOM) and natural organic matter (NOM) during moderate pre-oxidation of potassium permanganate composite (PPC) to enhance coagulation remain insufficiently understood. In this study, excitation-emission matrix fluorescence spectroscopy coup...

Mechanics, Fracture, and Fragmentation of Thrombi: A Computational Study Review.

Thrombosis drives myocardial infarction, acute ischemic stroke and pulmonary embolism, yet more than half of patients undergoing mechanical thrombectomy fail to achieve functional independence, and residual thrombus is detected in up to 91% of cases after catheter-directed thrombolysis. These persistent clinical failures reflect a fundamental gap: thrombus removal is not merely dissolution or extr...

Novel biomarkers for the differential diagnosis of paediatric MYH9-related diseases and immune thrombocytopenia revealed by plasma proteomics.

Differentiating myosin heavy chain 9 (MYH9)-related disease (MYH9-RD) from immune thrombocytopenia (ITP) remains clinically challenging. This study ut...

Sex differences in microvascular patterns associated with low- and high-risk for cardiovascular disease.

BACKGROUND: The role of the microcirculation in cardiovascular health in males and females is not fully understood. Skin microvascular function can be...

Bigger Is Not Always Better: Computational Efficiency in Lexical Prehospital Triage Modeling.

INTRODUCTION: In future large-scale combat operations, military medics will likely face staggering numbers of casualties in the face of resource const...

The High-Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration.

The lumbar intervertebral disc high-intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2-weighted magnetic resonance imaging...

Retinal Pigment Epithelium and Microglia Transplantation in Age-related Macular Degeneration.

Age-related macular degeneration (AMD) remains a leading cause of irreversible blindness worldwide, characterized by the progressive breakdown of the ...

AI-augmented MALDI-TOF MS screening reveals a high burden of undiagnosed monoclonal gammopathy in adult patients.

Monoclonal gammopathy of undetermined significance is a common precursor of multiple myeloma, yet its prevalence and clinical distribution remain poor...

Machine learning-based identification of cardiovascular risk modifiers in patients with very high LDL cholesterol: A cross-sectional study.

Individuals with LDL cholesterol (LDL-C) ≥ 190 mg/dL face a markedly increased risk of major adverse cardiovascular events (MACE). Traditional risk ca...

Intracardiac Echocardiography-Guided Left Atrial Appendage Occlusion: A Comprehensive Narrative Review.

Intracardiac echocardiography (ICE) is an alternative to transesophageal echocardiography for imaging guidance during left atrial appendage occlusion ...

Longitudinal Changes in Acid-Base Parameters From Dialysis Initiation to Death in Maintenance Hemodialysis Patients.

INTRODUCTION: Blood gas analysis is routinely performed in hemodialysis patients to monitor acid-base status and serum potassium. Despite frequent tes...

An Accelerated Training Framework for Physics-Informed Neural Networks: Applications in Ultrafast Ultrasound Blood Flow Imaging.

Ultrafast ultrasound blood flow imaging is a state-of-the-art technique for depiction of complex blood flow dynamics in vivo through thousands of full...

Noninvasive diabetes mellitus classification based on HbA1c using the mel-frequency cepstral coefficients from the photoplethysmographic signal.

Diabetes mellitus (DM) is a metabolic condition with improper regulation of blood sugar levels and is one of the leading global causes of death. G...

Research and application of machine learning models based on multimodal big data for precise transfusion management in acute myeloid leukaemia.

Acute myeloid leukaemia (AML) is a highly heterogeneous haematologic malignancy in which transfusion support represents an essential component of comp...

Beyond Thresholds: Can Machine Learning Improve Trauma Field Triage?

BackgroundAccurate triage of trauma patients by Emergency Medical Services (EMS) is essential for optimal outcomes and resource allocation. The 2021 N...

Integration of hierarchical clustering in hematologic biomarkers prediction for endocrine toxicity during immunotherapy in lung cancer patients.

Immune check-point inhibitors (ICIs) have outstandingly changed the treatment for lung cancer patients providing longer progression-free (PFS) and ove...

Classifying Diabetic and Healthy β-Cells in Type 2 Diabetes Using Machine Learning on Single-Cell RNA Sequencing Data.

Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms...

Predictor Of Mortality In Obstructive Sleep Apnoea: Results of Explainable Deep Learning based Survival Analysis From a 15-Year Follow-Up.

INTRODUCTION: Obstructive sleep apnoea (OSA) is a respiratory disorder with comorbidities of several nature, from cardiovascular to renal ones. OSA is...

Identifying treatment-responsive patient subgroups in a neutral clinical trial of Intensive blood pressure reduction in acute intracerebral hemorrhage: A post hoc explainable machine learning analysis.

The Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-2) trial reported no overall benefit from intensive blood pressure (BP) reduction i...

Transforming blood-derived episignatures into cell-type-agnostic classifiers: A shortcut to prenatal episignatures.

DNA methylation (DNAm) episignatures are stable disorder-specific epigenetic patterns that serve as valuable biomarkers for assessing variant pathogen...