Latest AI and machine learning research in hepatitis for healthcare professionals.
Degrons are short protein segments that direct proteins for degradation via the ubiquitin-proteasome system, ensuring the removal of signaling proteins and clearance of misfolded proteins. We have performed a large-scale screen of more than 200,000 30-residue peptides from more than 5000 human cytosolic proteins, achieving 99.7% coverage. We find that 19% of peptides act as strong degrons, 30% as ...
ConspectusViral proteases are essential enzymes required for viral replication and assembly, making them prime antiviral drug targets. However, under the selective pressure of protease inhibitors, viruses can acquire mutations that reduce drug binding efficacy, posing significant challenges in both chronic infections (e.g., HIV, HCV) and acute infections like COVID-19, where mutations in the SARS-...
Early diagnosis of liver cancer is crucial for developing clinical treatment strategies and improving patient survival rates. However, current diagnos...
PURPOSE: Adipose tissue innervation is critical for regulating lipolysis, adipogenesis, and thermogenesis, yet the mechanisms that establish and maint...
Cancer immunotherapies trigger highly variable responses in patients and in genetically identical mouse models. To assess the intrinsic stochasticity ...
OBJECTIVES: Liver surface nodularity (LSN) is a recognized non-invasive biomarker of cirrhosis. This study introduces auto-LSN, an artificial intellig...
BACKGROUND: Influenza vaccination is an effective measure for reducing the risk of severe influenza infection. However, the task of achieving adequate...
Multidisciplinary teams (MDTs) are central to treatment planning for colorectal cancer liver metastases (CRCLM) but require time and consistent access...
BACKGROUND: Hepatitis B (HBV) is a chronic viral infection that can lead to cirrhosis, liver failure, and liver cancer, and has a profound impact on t...
BACKGROUND AND AIMS: Liver fibrosis poses a major health threat globally, with an acute shortage of effective treatments to stop or reverse its progre...
The evolution of the viruses is rapidly becoming a global challenge to the creation of vaccines since the new variants are often capable of escaping t...
Inclusion of physiologically relevant clearance mechanisms into organ-on-a-chip models is essential to reproduce tissue exposure and predict therapeut...
BACKGROUND: Despite progress in childhood vaccination, many children in low- and middle-income countries, including Ethiopia, remain unvaccinated, pre...
OBJECTIVE: To build natural language processing (NLP) strategies to characterize measures of genetic counseling (GC) efficiency and classify measures ...
Dietary extracellular vesicles (D-EVs), which are nanoscale extracellular vesicles derived from edible food sources such as plants, animals, and micro...
Identifying conserved, immunogenic proteins that confer protection against Streptococcus pneumoniae (pneumococcus) colonization could enable developme...
Interleukin-2 (IL-2) is a pivotal cytokine involved in regulating immune responses, particularly in the activation and proliferation of T cells. Inter...
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness, imposing a significant burden on global health and society. Here, ...