Hepatitis

Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to persist, demonstrating the risks posed by emerging infectious diseases to national security, public health, and the economy. Development of new vaccines and antibodies for emerging viral threats requires substantial resources and time, and traditional development platforms for vaccines and antibodies are often too slow to co...

Development and validation of a machine learning-based prediction model for hepatorenal syndrome in liver cirrhosis patients using MIMIC-IV and eICU databases.

Hepatorenal syndrome (HRS) is a key contributor to poor prognosis in liver cirrhosis. This study aims to leverage the database to build a predictive model for early identification of high-risk patients. From two sizable public databases, we retrieved pertinent information about the cirrhosis patients' therapies, comorbidities, laboratory results, and demographics. Patients from the eICU database s...

Humoral and cell-mediated immune responses to COVID-19 vaccines up to 6 months post three-dose primary series in adults with inborn errors of immunity and their breakthrough infections.

PURPOSE: Many individuals with inborn errors of immunity (IEIs) have poor humoral immune (HI) vaccine responses. Only a few studies have examined spec...

Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.

Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targe...

The efficiency of artificial intelligence for management and clinical decision-making in the identification of patients with hidden HCV infection (Intelligen-C strategy).

INTRODUCTION: Artificial intelligence (AI) allows the optimization of diagnostic processes for hepatitis C virus (HCV) patients. Our objective was to ...

Applications of Machine Learning Approaches for the Discovery of SARS-CoV-2 PLpro Inhibitors.

The global impact of SARS-CoV-2 highlights the need for treatments beyond vaccination, given the limited availability of effective medications. While ...

Therapeutic potential of against monkeypox: antioxidant, anti-inflammatory, and computational insights.

BACKGROUND: Monkeypox (Mpox) is a re-emerging zoonotic disease with limited therapeutic options, necessitating the exploration of novel antiviral agen...

Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes.

BACKGROUND: Hepatocellular carcinoma (HCC) accounts for over 80% of primary liver cancers and is the third leading cause of cancer-related deaths worl...

The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning.

Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy response. This study aims to...

The influence of factors related to public health campaigns on vaccination behavior among population of Wuxi region, China.

BACKGROUND: Public health campaigns are essential for promoting vaccination behavior, but factors such as socioeconomic status, geographical location,...

CT-Based Body Composition Measures and Systemic Disease: A Population-Level Analysis Using Artificial Intelligence Tools in Over 100,000 Patients.

CT-based abdominal body composition measures have shown associations with important health outcomes. Advances in artificial intelligence (AI) now all...

Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

BACKGROUND: The vitamin D pathway contributes to the microbicidal activity of macrophages against infection. In addition to induction of this pathway...

The role of artificial intelligence in pandemic responses: from epidemiological modeling to vaccine development.

Integrating Artificial Intelligence (AI) across numerous disciplines has transformed the worldwide landscape of pandemic response. This review investi...

Fibrosis and inflammatory activity diagnosis of chronic hepatitis C based on extreme learning machine.

The traditional diagnosis of chronic hepatitis C usually relies on liver biopsy. Diagnosing chronic hepatitis C based on serum indices provides a non-...

Noninvasive diagnosis of significant liver fibrosis in patients with chronic hepatitis B using nomogram and machine learning models.

This study aims to construct and validate noninvasive diagnosis models for evaluating significant liver fibrosis in patients with chronic hepatitis B ...

From Outbreaks to Artificial Intelligence: A Comprehensive Review of Monkeypox Virus Epidemiology, Diagnosis, Treatment, Vaccination, and Deep Learning Applications.

After the global impact of the COVID-19 pandemic, concerns over virus transmission have risen. A state of health emergency was declared in 2022 due t...

ViroNia: LSTM based proteomics model for precise prediction of HCV.

Classification of viruses carries important implications in terms of understanding their evolution and the designing of interventions. This study intr...

Association between serum endocan levels and organ failure in hospitalized patients with cirrhosis.

BACKGROUND & AIMS: Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable bio...

Impact of a trace mineral injection at weaning on growth, behavior, and inflammatory, antioxidant, and immune responses of beef calves.

Two experiments evaluated the effects of an injectable trace mineral (ITM) solution at weaning on trace mineral (TM) status, inflammatory and antioxid...

AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides.

Human respiratory syncytial virus (RSV) remains a significant global health threat, particularly for vulnerable populations. Despite extensive researc...