Infectious Disease

Hepatitis

Latest AI and machine learning research in hepatitis for healthcare professionals.

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A Machine Learning Approach for MicroRNA Precursor Prediction in Retro-transcribing Virus Genomes.

Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially classification. In order to achieve successful classification, many parameters need to be considered such as data quality, choice of classifier s...

Dec 22 2016 28187417

An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge.

Originally isolated from swine, the proposed influenza D virus has since been shown to be common in cattle. Inoculation of IDV to naïve calves resulted in mild respiratory disease histologically characterized by tracheitis. As several studies have associated the presence of IDV with acute bovine respiratory disease (BRD), we sought to investigate the efficacy of an inactivated IDV vaccine. Vaccina...

Dec 21 2016 28110784
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.

Lymphopenic conditions lead to expansion of memory-like T cells (T), which develop from naïve T cells by spontaneous proliferation. T cells are often ...

Dec 21 2016 28066432
Development of a Zika Virus Infection Model in Cynomolgus Macaques.

Limited availability of Indian rhesus macaques (IRM) is a bottleneck to study Zika virus (ZIKV) pathogenesis and evaluation of appropriate control mea...

Dec 19 2016 28066354
High serum ferritin is associated with worse outcome of patients with decompensated cirrhosis.

BACKGROUND: Studies in patients with decompensated cirrhosis showed a correlation between serum ferritin levels and patients' prognosis. Besides, red ...

Dec 8 2016 28243043
Plasma Transfusion in Patients With Cirrhosis in China: A Retrospective Multicenter Cohort Study.

Patients with cirrhosis used to be associated with frequent use of blood components because of their complex disorder of hemostasis and bleeding compl...

Dec 2 2016 28063764
A methodology for automated CPA extraction using liver biopsy image analysis and machine learning techniques.

BACKGROUND AND OBJECTIVE: Collagen proportional area (CPA) extraction in liver biopsy images provides the degree of fibrosis expansion in liver tissue...

Nov 29 2016 28254091
Non-ionic iodinated contrast media related immediate reactions: A mechanism study of 27 patients.

The underlying mechanism of non-ionic iodinated contrast media-related immediate reactions was evaluated in this study. Patients presenting at least g...

Nov 29 2016 28081790
Development of chronic hepatitis B infection in a hepatitis B vaccine responder.

The Hepatitis B vaccine is highly effective for the prevention of hepatitis B (HBV) infection. We report the development of chronic HBV infection (Gen...

Nov 12 2016 28266264
Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.

BACKGROUND: Temporary abdominal closure (TAC) may be performed for cirrhotic patients undergoing emergent laparotomy. The effects of cirrhosis on phys...

Nov 11 2016 28457316
Development of amino functionalized carbon coated magnetic nanoparticles and their application to electrochemical detection of hybridization of nucleic acids.

In our study, the development of amino functionalized carbon coated magnetic nanoparticles (NH-CC-MNPs) and their usage for electrochemical detection ...

Nov 11 2016 28107914
An algorithm for direct causal learning of influences on patient outcomes.

OBJECTIVE: This study aims at developing and introducing a new algorithm, called direct causal learner (DCL), for learning the direct causal influence...

Nov 5 2016 28363452
Nuclear Magnetic Resonance (NMR) Study for the Detection and Quantitation of Cholesterol in HSV529 Therapeutic Vaccine Candidate.

This study describes the NMR-based method to determine the limit of quantitation (LOQ) and limit of detection (LOD) of cholesterol, a process-related ...

Nov 1 2016 28694932
The Role of Direct and Visual Force Feedback in Suturing Using a 7-DOF Dual-Arm Teleoperated System.

The lack of haptic feedback in robotics-assisted surgery can result in tissue damage or accidental tool-tissue hits. This paper focuses on exploring t...

Oct 12 2016 28113408
PHENOLIC PROFILE OF L. GROWING IN EGYPT AND ITS CYTOTOXIC AND ANTIVIRAL ACTIVITIES.

BACKGROUND: L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constitu...

Sep 29 2016 28480370
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.

BACKGROUND: Tenofovir alafenamide is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than tenofovir disop...

Sep 22 2016 28404091
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.

BACKGROUND: The novel prodrug tenofovir alafenamide delivers the nucleotide reverse transcriptase inhibitor tenofovir to target cells more efficiently...

Sep 22 2016 28404092
Clinical chemistry in higher dimensions: Machine-learning and enhanced prediction from routine clinical chemistry data.

Big Data is having an impact on many areas of research, not the least of which is biomedical science. In this review paper, big data and machine learn...

Jul 22 2016 27452181
An improved method for predicting interactions between virus and human proteins.

The interaction of virus proteins with host proteins plays a key role in viral infection and consequent pathogenesis. Many computational methods have ...

Jul 10 2016 27397631
Structure-activity relationship studies of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters against influenza viruses.

A series of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters were synthesized via the condensation of methyl rupestonate with various aldehydes in the...

Jun 6 2016 28196702
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