Infectious Disease

Hepatitis

Latest AI and machine learning research in hepatitis for healthcare professionals.

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Heavy chain sequence-based classifier for the specificity of human antibodies.

Antibodies specifically bind to antigens and are an essential part of the immune system. Hence, antibodies are powerful tools in research and diagnostics. High-throughput sequencing technologies have promoted comprehensive profiling of the immune repertoire, which has resulted in large amounts of antibody sequences that remain to be further analyzed. In this study, antibodies were downloaded from ...

Jan 17 2022 34953464

A deep learning method for repurposing antiviral drugs against new viruses via multi-view nonnegative matrix factorization and its application to SARS-CoV-2.

The outbreak of COVID-19 caused by SARS-coronavirus (CoV)-2 has made millions of deaths since 2019. Although a variety of computational methods have been proposed to repurpose drugs for treating SARS-CoV-2 infections, it is still a challenging task for new viruses, as there are no verified virus-drug associations (VDAs) between them and existing drugs. To efficiently solve the cold-start problem p...

Jan 17 2022 34965582
Vaccine Design by Reverse Vaccinology and Machine Learning.

Reverse vaccinology (RV) is the state-of-the-art vaccine development strategy that starts with predicting vaccine antigens by bioinformatics analysis ...

Jan 1 2022 34784028
Artificial Intelligence in Vaccine and Drug Design.

Knowledge in the fields of biochemistry, structural biology, immunological principles, microbiology, and genomics has all increased dramatically in re...

Jan 1 2022 34914045
Artificial Intelligence for Vaccine Design.

Often likened to "the new electricity," artificial intelligence (AI) has broad and sweeping impact in many areas. Perhaps most exciting among these ar...

Jan 1 2022 34918238
Machine Learning Prediction of Antimicrobial Peptides.

Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One strategy is to develop a new generation of antimicrobials. ...

Jan 1 2022 35298806
Health Promotion, Health Literacy and Vaccine Hesitancy: The Role of Humanoid Robots.

The use of humanoid robot technologies within global healthcare settings is rapidly evolving; however, the potential of robots in health promotion and...

Jan 1 2022 35341351
Cloning Strategies for the Generation of Recombinant Capripoxvirus Through the Use of Screening and Selection Markers.

The ability to manipulate capripoxvirus through gene knockouts and gene insertions has become an increasingly valuable research tool in elucidating th...

Jan 1 2022 35118623
A Multimodal Direct Gaze Interface for Wheelchairs and Teleoperated Robots.

Gaze-based interfaces are especially useful for people with disabilities involving the upper limbs or hands. Typically, users select from a number of ...

Nov 1 2021 34892283
Deep learning identifies synergistic drug combinations for treating COVID-19.

Effective treatments for COVID-19 are urgently needed. However, discovering single-agent therapies with activity against severe acute respiratory synd...

Sep 28 2021 34526388
Current status and future perspectives of computational studies on human-virus protein-protein interactions.

The protein-protein interactions (PPIs) between human and viruses mediate viral infection and host immunity processes. Therefore, the study of human-v...

Sep 2 2021 33693490
SMMPPI: a machine learning-based approach for prediction of modulators of protein-protein interactions and its application for identification of novel inhibitors for RBD:hACE2 interactions in SARS-CoV-2.

Small molecule modulators of protein-protein interactions (PPIs) are being pursued as novel anticancer, antiviral and antimicrobial drug candidates. W...

Sep 2 2021 33839740
Dynamic Survival Analysis for EHR Data with Personalized Parametric Distributions.

The widespread availability of high-dimensional electronic healthcare record (EHR) datasets has led to significant interest in using such data to deri...

Aug 1 2021 35425906
Extracting postmarketing adverse events from safety reports in the vaccine adverse event reporting system (VAERS) using deep learning.

OBJECTIVE: Automated analysis of vaccine postmarketing surveillance narrative reports is important to understand the progression of rare but severe va...

Jul 14 2021 33647938
AI-based spectroscopic monitoring of real-time interactions between SARS-CoV-2 and human ACE2.

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades a human cell via human angiotensin-converting enzyme 2 (h...

Jun 29 2021 34185681
High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.

Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometr...

Apr 13 2021 33852838
Artificial intelligence in precision medicine in hepatology.

The advancement of investigation tools and electronic health records (EHR) enables a paradigm shift from guideline-specific therapy toward patient-spe...

Mar 1 2021 33709606
Low Predictability of Readmissions and Death Using Machine Learning in Cirrhosis.

INTRODUCTION: Readmission and death in cirrhosis are common, expensive, and difficult to predict. Our aim was to evaluate the abilities of multiple ar...

Feb 1 2021 33038139
ASAS-NANP SYMPOSIUM: Applications of machine learning for livestock body weight prediction from digital images.

Monitoring, recording, and predicting livestock body weight (BW) allows for timely intervention in diets and health, greater efficiency in genetic sel...

Feb 1 2021 33626149
Comparative Study of Efficacy of Intralesional Purified Protein Derivative (PPD) Versus Intralesional Measles, Mumps, and Rubella (MMR) Vaccine in Management of Multiple Viral Warts.

BACKGROUND: Multiple viral warts represent a frustrating challenge for both patients and physicians. Management is difficult, primarily due to recalci...

Jan 1 2021 35283602
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