Hypertension

In silico prediction of drug-induced cardiotoxicity with ensemble machine learning and structural pattern recognition.

Drug-induced cardiotoxicity poses a significant risk to human health, and reliable predictive models are needed for safety assessment. In this study, a range of machine and deep learning models were developed for five cardiotoxicity end points, including heart failure (HF), arrhythmia (ARR), heart block (HB), hypertension (HP), and heart attack (HA). A total of 110 predictive models were construct...

Predicting Retinal Nerve Fiber Layer Thickness From Ocular Hypertension Treatment Study Optic Disc Photographs.

IMPORTANCE: Deep learning predictions of retinal nerve fiber layer (RNFL) thickness derived from optic disc photographs may help to determine risk for development of primary open-angle glaucoma (POAG) in patients with ocular hypertension.

Towards a comprehensive characterization of arteries and veins in retinal imaging.

Retinal fundus imaging is crucial for diagnosing and monitoring eye diseases, which are often linked to systemic health conditions such as diabetes an...

Prevalence and determinants of hypertension among adults of reproductive age in Tanzania: analysis of a cross-sectional Demographic and Health Survey.

OBJECTIVE: We aimed to estimate prevalence and identify determinants of hypertension in adults aged 15-49 years in Tanzania.

Predicting pulmonary hemodynamics in pediatric pulmonary arterial hypertension using cardiac magnetic resonance imaging and machine learning: an exploratory pilot study.

PURPOSE: Pulmonary arterial hypertension (PAH) significantly affects the pulmonary vasculature, requiring accurate estimation of mean pulmonary arteri...

Association between metal mixture in urine and abnormal blood pressure and mediated effect of oxidative stress based on BKMR and Machine learning method.

BACKGROUND: Exposure to heavy metals represents a significant risk factor for hypertension and blood pressure disorders. Notably, current evidence ind...

Left ventricular systolic dysfunction screening in muscular dystrophies using deep learning-based electrocardiogram interpretation.

BACKGROUND: Routine echocardiographic monitoring is recommended in muscular dystrophy patients to detect left ventricular systolic dysfunction (LVSD) ...

Gene as a Molecular Target Potentially Shared by Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Drug Repurposing Prospect with Aminoglutethimide.

Idiopathic pulmonary fibrosis (IPF) and pulmonary hypertension (PH) are two chronic conditions that can coexist occasionally, resulting in high morbid...

Predicting rapid kidney function decline in middle-aged and elderly Chinese adults using machine learning techniques.

The rapid decline of kidney function in middle-aged and elderly people has become an increasingly serious public health problem. Machine learning (ML)...

Out-of-distribution reject option method for dataset shift problem in early disease onset prediction.

Machine learning is increasingly used to predict lifestyle-related disease onset using health and medical data. However, its predictive accuracy for u...

The use of imaging in the diagnosis and treatment of thromboembolic pulmonary hypertension.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a potentially life-threatening condition, classified as group 4 pulmonary hypertension (PH), ...

Gut microbiota, metabolites, and pulmonary hypertension: Mutual regulation and potential therapies.

Pulmonary hypertension is a progressive condition characterized by increased pulmonary vascular pressure and resistance, ultimately leading to right h...

Blood pressure monitoring is key in aortic dissection.

Blood pressure (BP) control is essential for both the prevention and long-term management of aortic dissection. While office BP monitoring remains the...

Artificial intelligence-enhanced electrocardiogram diastolic function grade predicts post-septal myectomy mortality in hypertrophic cardiomyopathy.

BACKGROUNDS: Diastolic dysfunction is an important pathophysiologic feature of hypertrophic cardiomyopathy that is often challenging to determine noni...

High burden of premature ventricular contractions upregulates transcriptional markers of inflammation and promotes adverse cardiac remodeling linked to cardiomyopathy.

Premature ventricular contractions (PVCs) are the most prevalent ventricular arrhythmia in adults. High PVC burden can lead to left ventricular (LV) s...

Hypertension precision medicine: the promise and pitfalls of pharmacogenomics.

Pharmacogenomics (PGx) has the potential to revolutionize hypertension management by tailoring antihypertensive therapy based on genetic profiles. Des...

Immunogenic cell death biomarkers for sepsis diagnosis and mechanism via integrated bioinformatics.

Immunogenic cell death (ICD) has been implicated in sepsis, a condition with high mortality, through mechanisms involving endoplasmic reticulum stress...

Comparison of seven machine learning models in hypertension classification using photoplethysmographic and anthropometric data.

This study presents an algorithm for classifying individuals into four hypertension categories (healthy, prehypertension, Stage 1, and Stage 2) using ...

When is imaging needed to assess the response to treatment in cardiac amyloidosis.

PURPOSE OF REVIEW: Cardiac amyloidosis is characterized by systolic and diastolic abnormalities due to deposition of amyloid fibril within the myocard...

Diagnostic value of fully automated CT pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease.

OBJECTIVES: To evaluate the value of employing artificial intelligence (AI)-assisted CT pulmonary angiography (CTPA) for patients with chronic thrombo...