Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Propofol-associated Hypertriglyceridemia: Development and Multicenter Validation of a Machine-Learning-Based Prediction Tool.

To develop and validate an explainable machine learning (ML) tool to help clinicians predict the risk of propofol-associated hypertriglyceridemia in critically ill patients receiving propofol sedation. Patients from 11 intensive care units (ICUs) across five Mayo Clinic hospitals were included if they met the following criteria: a) ≥ 18 years of age, b) received propofol infusion while on invasiv...

May 15 2025 40370218

Exploring the impact of artificial intelligence-enabled decision aids in improving patient inclusivity, empowerment, and education in urology: a systematic review by EAU endourology.

PURPOSE OF REVIEW: The implementation of artificial intelligence (AI) in urology has the potential to enhance patient outcomes through the provision of intelligent tools, such as AI-enabled decision aids (AIDAs), which can support personalized care. The objective of this systematic review is to determine the role of AIDAs in educating and empowering patients, particularly those from underrepresent...

May 15 2025 40371494
De Novo Design of Highly Stable Binders Targeting Dihydrofolate Reductase in Klebsiella pneumoniae.

The study aims to design novel therapeutic inhibitors targeting the DHFR protein of Klebsiella pneumoniae. However, challenges like bacterial resistan...

May 15 2025 40371895
Toward Ultralow-Power Neuromorphic Speech Enhancement With Spiking-FullSubNet.

Speech enhancement (SE) is critical for improving speech intelligibility and quality in various audio devices. In recent years, deep learning-based me...

May 15 2025 40372867
ITGAV, a specific biomarker associated with the pathogenesis of idiopathic pulmonary fibrosis.

Objective Idiopathic pulmonary fibrosis (IPF), which radiologically/pathologically manifests mainly as usual interstitial pneumonia (UIP), is easily c...

May 15 2025 40374686
Distinguishing critical microbial community shifts from normal temporal variability in human and environmental ecosystems.

Differentiating significant microbial community changes from normal fluctuations is vital for understanding microbial dynamics in human and environmen...

May 15 2025 40374711
An automated multi parameter neural architecture discovery framework using ChatGPT in the backend.

Building efficient neural network architectures for a given dataset can be a time-consuming task requiring extensive expert knowledge. This task becom...

May 15 2025 40374751
SARS-CoV-2: lessons in virus mutation prediction and pandemic preparedness.

The COVID-19 pandemic has prompted an unprecedented global response. In particular, extraordinary efforts have been dedicated toward monitoring and pr...

May 15 2025 40378522
SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome viru...

May 14 2025 40340535
Coumarin hybrids: dual-target candidates for future antimicrobial and antitubercular therapies.

AIMS: This study aimed to synthesize, characterize, and evaluate the antimicrobial and antitubercular activities of two novel series of coumarin-based...

May 12 2025 40353302
Secretions Induce Shifts in Macrolactin Composition and Reduction in Antimicrobial Activity of BNC5.

, a pathogen causing bacterial wilt, threatens global crop production, necessitating sustainable biocontrol solutions. is a promising biocontrol agen...

May 12 2025 40353476
Multiple mutations in succinate dehydrogenase subunits conferring resistance to fungicide Pydiflumetofen in Magnaporthe oryzae.

BACKGROUND: Magnaporthe oryzae is the causal agent of rice blast disease. Pydiflumetofen, a novel succinate dehydrogenase inhibitor (SDHI), has promis...

May 12 2025 40353615
Anti- activity of clerodane diterpenes and their methyl ester derivatives from (Alismataceae).

The effect of the EtOAc extract of leaves against (trypomastigotes) was evaluated . As this extract caused 100% parasite reduction (at 300 µg/mL), i...

May 12 2025 40353735
Surveillance of SARS-CoV-2 RNA in wastewater treatment plants in Türkiye, Istanbul: a long-term study and statistical analysis.

Wastewater-based epidemiology (WBE) is a powerful method that allows community surveillance to identify diseases/pandemic dynamics in a city, especial...

May 12 2025 40353924
Selected comorbidities and the probability of ART switch in PWH with undetectable HIV-RNA: a retrospective analysis in Italy.

OBJECTIVES: To estimate the incidence of comorbidities in persons with HIV (PWH) with a stable viral load (VL) of ≤50 copies/mL and evaluate the likel...

May 12 2025 40354062
Cytotoxicity and Antiparasitic Effects of Toltrazuril Against Enteromyxum leei in Olive Flounders: In Vitro and In Vivo Analyses.

The parasite Enteromyxum leei causes serious emaciation disease in marine fish species. Toltrazuril exhibits antiparasitic effects; however, the simul...

May 12 2025 40354608
Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.

BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumat...

May 12 2025 40355954
Optimization of process conditions and kinetic microbial growth for milk fermentation using domestic kefir grains from Costa Rica.

Kefir, a fermented milk product, differs from yogurt due to its unique microbial composition, offering a broad spectrum of health benefits. Given its ...

May 12 2025 40356561
Exploring indigenous South African plants as alternative treatments for dermatophytosis: Focusing on the antifungal properties and mechanism of action of Searsia lancea.

Numerous medicinal plants are reported to have activity against dermatophytes, however, there are limited studies providing insights into their mechan...

May 12 2025 40339615
Lidocaine exhibits antileishmanial and immunomodulatory activities in an in vitro model of tegumentary leishmaniasis.

Local anesthetics have been shown to inhibit or delay the progression of tegumentary leishmaniasis (TL) in hamster models, although the mechanisms und...

May 11 2025 40339877
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