Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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A deep learning approach predicting the activity of COVID-19 therapeutics and vaccines against emerging variants.

Understanding which viral variants evade neutralization is crucial for improving antibody-based treatments, especially with rapidly evolving viruses like SARS-CoV-2. Yet, conventional assays are labor intensive and cannot capture the full spectrum of variants. We present a deep learning approach to predict changes in neutralizing antibody activity of COVID-19 therapeutics and vaccine-elicited sera...

Nov 27 2024 39604453

Enhanced prediction of hemolytic activity in antimicrobial peptides using deep learning-based sequence analysis.

Antimicrobial peptides (AMPs) are a promising class of antimicrobial drugs due to their broad-spectrum activity against microorganisms. However, their clinical application is limited by their potential to cause hemolysis, the destruction of red blood cells. To address this issue, we propose a deep learning model based on convolutional neural networks (CNNs) for predicting the hemolytic activity of...

Nov 27 2024 39604856
Machine learning predicts pulmonary Long Covid sequelae using clinical data.

Long COVID is a multi-systemic disease characterized by the persistence or occurrence of many symptoms that in many cases affect the pulmonary system....

Nov 27 2024 39604988
Screening for frequent hospitalization risk among community-dwelling older adult between 2016 and 2023: machine learning-driven item selection, scoring system development, and prospective validation.

BACKGROUND: Screening for frequent hospitalizations in the community can help prevent super-utilizers from growing in the inpatient population. Howeve...

Nov 27 2024 39664532
Current update on the neurological manifestations of long COVID: more questions than answers.

Since the outbreak of the COVID-19 pandemic, there has been a global surge in patients presenting with prolonged or late-onset debilitating sequelae o...

Nov 27 2024 39850323
Integrating machine learning and multitargeted drug design to combat antimicrobial resistance: a systematic review.

Antimicrobial resistance (AMR) is a critical global health challenge, undermining the efficacy of antimicrobial drugs against microorganisms like bact...

Nov 26 2024 39535825
Two-step graph propagation for incomplete multi-view clustering.

Incomplete multi-view clustering addresses scenarios where data completeness cannot be guaranteed, diverging from traditional methods that assume full...

Nov 26 2024 39622185
Feasibility study of machine learning to explore relationships between antimicrobial resistance and microbial community structure in global wastewater treatment plant sludges.

Wastewater sludges (WSs) are major reservoirs and emission sources of antibiotic resistance genes (ARGs) in cities. Identifying antimicrobial resistan...

Nov 26 2024 39603473
Bacteriophage-Activated DNAzyme Hydrogels Combined with Machine Learning Enable Point-of-Use Colorimetric Detection of Escherichia coli.

Developing cost-effective, consumer-accessible platforms for point-of-use environmental and clinical pathogen testing is a priority, to reduce relianc...

Nov 26 2024 39588857
The translation of in-house imaging AI research into a medical device ensuring ethical and regulatory integrity.

This manuscript delineates the pathway from in-house research on Artificial Intelligence (AI) to the development of a medical device, addressing criti...

Nov 26 2024 39612599
Mining biology for antibiotic discovery.

The rise of antibiotic resistance calls for innovative solutions. The realization that biology can be mined digitally using artificial intelligence ha...

Nov 26 2024 39591471
Reduction of by Chlorella-Mediated Antimicrobial Photodynamic Therapy.

Nowadays, antimicrobial photodynamic therapy (aPDT) has been introduced as one of the minimally invasive methods for disinfection of the surfaces of ...

Nov 26 2024 39802909
SLInterpreter: An Exploratory and Iterative Human-AI Collaborative System for GNN-Based Synthetic Lethal Prediction.

Synthetic Lethal (SL) relationships, though rare among the vast array of gene combinations, hold substantial promise for targeted cancer therapy. Desp...

Nov 25 2024 39316494
PhenoFlow: A Human-LLM Driven Visual Analytics System for Exploring Large and Complex Stroke Datasets.

Acute stroke demands prompt diagnosis and treatment to achieve optimal patient outcomes. However, the intricate and irregular nature of clinical data ...

Nov 25 2024 39316495
Integrated machine learning and physics-based methods assisted de novo design of Fatty Acyl-CoA synthase inhibitors.

BACKGROUND: Tuberculosis is an infectious disease that has become endemic worldwide. The causative bacteria (Mtb) is targeted via several exciting dr...

Nov 25 2024 39587794
Social Robots and Sensors for Enhanced Aging at Home: Mixed Methods Study With a Focus on Mobility and Socioeconomic Factors.

BACKGROUND: Population aging affects society, with a profound impact on daily activities for those of a low socioeconomic status and with motor impair...

Nov 25 2024 39586076
Antifungal properties of carvone and linalool against species: Preliminary Screening Study.

BACKGROUND AND PURPOSE: By harnessing the power of nature, researchers can potentially discover new therapeutic options that are safe, effective, and ...

Nov 25 2024 40330786
Artificial intelligence-powered image analysis: A paradigm shift in infectious disease detection.

The global burden of infectious diseases significantly affects mortality rates, with their varying symptoms making it challenging to assess and determ...

Nov 23 2024 39608041
AI-assisted diagnosis of vulvovaginal candidiasis using cascaded neural networks.

UNLABELLED: Vulvovaginal candidiasis (VVC) is a prevalent fungal ailment affecting women globally. Timely and accurate diagnosis is crucial. Tradition...

Nov 22 2024 39576103
Unsupervised Learning-Assisted Acoustic-Driven Nano-Lens Holography for the Ultrasensitive and Amplification-Free Detection of Viable Bacteria.

Bacterial infection is a crucial factor resulting in public health issues worldwide, often triggering epidemics and even fatalities. The accurate, rap...

Nov 22 2024 39575510
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