Infectious Disease

Manganese Metabolism-Related Gene Signatures as Diagnostic Biomarkers for Tuberculosis: Immune Infiltration Profiling and Molecular Subtype Identification.

BACKGROUND: Host metabolic programs are increasingly recognized as key modulators of tuberculosis (TB) immunopathology, yet manganese metabolism-related transcriptional signatures with diagnostic and immunological relevance remain insufficiently characterized. We aimed to identify manganese metabolism-linked biomarkers for TB diagnosis and to delineate their immune and regulatory context. METHODS:...

Formulation and stability design spaces for a new yellow fever vaccine.

Yellow fever (YF) is a life-threatening disease that is entirely preventable through vaccination. The objective of this study was to formulate a freeze-dried presentation of a live-attenuated, Vero cell-based yellow fever vaccine (vYF) with improved manufacturability and enhanced shelf-life. Considering four critical quality attributes (i.e., glass transition temperatures and infectious titers at ...

CT-based Deep Learning Model for Automatic Segmentation and Early Predicting of Pyogenic Liver Abscess Caused by Extended-Spectrum β-lactamase-Producing Enterobacteriaceae: A Multicenter Retrospective Study (CLASS2401).

RATIONALE AND OBJECTIVE: Pyogenic liver abscess (PLA) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PLA) presents major a...

Data-driven exploration of electronic nose technology to differentiate bacteria in blood cultures under biofilm-promoting conditions.

Biofilms are a major cause of delayed wound healing, yet current biofilm identification methods are limited by invasiveness, processing times, or spec...

Applying prior knowledge of regulatory signaling to investigate macrophage cAMP dynamics during Mycobacterium tuberculosis infection.

Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis, resides in host lung macrophages and has evolved unique processes to hijack hos...

Development of an expert-annotated chest X-ray dataset to support AI validation in tuberculosis diagnosis.

OBJECTIVES: To assess inter-rater agreement and diagnostic performance of six United States National Institute for Occupational Safety and Health-cert...

A machine learning-driven multitask framework for antibiotic resistance prediction in Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae bloodstream infections among hematological malignancy patients.

BACKGROUND: Inappropriate empirical antimicrobial therapy (IEAT) significantly increases mortality in patients with resistant Gram-negative bacteremia...

Performance evaluation of five major large language models in tuberculosis Q&A systems: A multidimensional assessment of readability, quality, and reliability.

BACKGROUND: Pulmonary tuberculosis (TB) is a chronic infectious disease that burdens patients and public health systems. Limited reach of traditional ...

A 2004-2025 Bibliometric Study of Genetic Variation and Multiomics Biomarkers in Sepsis Based on 940 Publications.

Sepsis is a highly heterogeneous syndrome, and conventional clinical indicators and single biomarkers often fail to capture its biological complexity ...

Bioinformatics analysis reveals the association of bile acid metabolism-related genes with sepsis.

BACKGROUND: Sepsis, is a life-threatening syndrome triggered by infection. Bile acid metabolism may be involved in the pathogenesis of sepsis, the und...

Machine learning-based analysis of drug resistance mutations in Mycobacterium tuberculosis.

Tuberculosis is a deadly airborne disease caused by Mycobacterium tuberculosis. Drug-resistant tuberculosis presents significant challenges for treatm...

Characterizing spatiotemporal spread of infectious diseases using ellipse-shaped transmission hotspots: application to dengue virus outbreaks.

BACKGROUND: Identifying transmission hotspots associated with micro-clustering patterns at the early stages of epidemics is helpful to characterize sp...

Identification of key genes associated with T cell exhaustion in HIV infection based on transcriptomic data.

BACKGROUND: Human immunodeficiency virus (HIV) is a lentivirus belonging to the retrovirus subclass. HIV specifically targets and infects human CD4 + ...

Pepholin, a bacteriophage holin-derived antimicrobial peptide with membrane-disruptive activity and therapeutic efficacy in MDR Pseudomonas aeruginosa burn wounds.

The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa poses a serious threat to burn wound healing, necessitating the development of alter...

Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.

Epigenetic editing achieves durable gene silencing through targeted modification of chromatin and DNA methylation states without altering the genomic ...

Antibiotic residue detection based on SERS technology: enhancement mechanisms, material innovations, and challenges in on-site applications.

In the face of the serious threat of antibiotic residues in food to human health, it is urgent to develop efficient and sensitive detection techniques...

Living Inorganic Nanomaterials: Design, Preparation, and Biomedical Applications.

Living inorganic nanomaterials are defined as inorganic nanostructures that are integrated with living bacteria, cells, or biologically active cell-de...

Spectroscopic discrimination of bacterial species of variable pathogenicity through explainable machine learning.

Rapid and accurate identification of bacterial pathogens and their degree of pathogenicity is essential for guiding antimicrobial therapy. Current cul...

Correction: Enterocutaneous Fistula-Associated Sepsis and Mortality: Development and Validation of a Multimodal Artificial Intelligence Prediction Model.

[This corrects the article DOI: 10.2196/79985.].

Infection prevention and control measures for Ebola and Marburg disease: a series of rapid reviews.

OBJECTIVES: An evidence synthesis informed the 2023 WHO infection prevention and control (IPC) guideline for Ebola disease (EBOD) and Marburg disease ...