Inflammatory Bowel Disease

Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling.

The intricate interplay between the gut microbiota and the GI tract has garnered significant attention, as growing evidence has identified the inflammasome as a crucial yet underexplored master regulator in microbiota-driven diseases. Triggered by a variety of dangers, inflammasomes are supramolecular complexes that regulate immune response. A large number of bacterial-derived inducers have been c...

Clinical significance of computer-aided quality assessment systems in colonoscopy: a comprehensive review.

Colonoscopy is the primary tool for colorectal cancer screening. High-quality colonoscopy is crucial for the detection of precancerous adenomas; however, the adenoma detection rate varies depending on the skill and experience of the endoscopist. Computer-aided quality assessment (CAQ) uses artificial intelligence (AI) technology to evaluate the quality of colonoscopy examinations. It plays an impo...

Assessing ChatGPT responses to patient questions on epidural steroid injections: A comparative study of general vs specific queries.

BACKGROUND: Artificial intelligence (AI) is becoming more integrated into healthcare, with large language models (LLMs) like ChatGPT being widely used...

Personalized dose reduction strategies for biologic disease-modifying antirheumatic drugs for treating axial spondyloarthritis: a clinical and economic evaluation with predictive modeling.

BACKGROUND: Axial spondyloarthritis (AS) is a chronic inflammatory disease that significantly affects quality of life and imposes a high economic burd...

Guideline-driven clinical decision support for colonoscopy patients using the hierarchical multi-label deep learning method.

BACKGROUND: Over 20 million colonoscopies are performed in China annually. An automatic clinical decision support system (CDSS) with accurate semantic...

[Psilocybin in the setting of treatment-resistant unipolar depression: A case report].

BACKGROUND: Current antidepressants have shown certain limitations in the treatment of unipolar depression. Their long onset of action, interactions, ...

Optimizing Treatment for Depression in Primary Care Using Psychotherapy Versus Antidepressant Medication in a Low-Resource Setting: Protocol for the OptimizeD Randomized Controlled Trial.

Psychotherapy and antidepressant medications are first-line treatments for depression, and they both have significant treatment effects on average. H...

Construction of a predictive model for relapse of primary autoimmune hemolytic anemia: a retrospective cohort study.

OBJECTIVES: To develop a machine learning-based model to predict the relapse risk of Primary Autoimmune Haemolytic Anaemia (AIHA) after the last remis...

Computer-aided diagnosis of colorectal polyps: assisted or autonomous?

Computer-aided diagnosis (CADx) in colonoscopy aims to improve the accuracy of diagnosing small polyps; however, its integration into clinical practic...

Diagnostic Methods and Biomarkers in Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) refers to a chronic inflammatory condition involving the GI tract that includes Crohn's disease (CD) and ulcerative c...

The Desmoid Dilemma: Challenges and Opportunities in Assessing Tumor Burden and Therapeutic Response.

Desmoid tumors are rare, locally invasive soft-tissue tumors with unpredictable clinical behavior. Imaging plays a crucial role in their diagnosis, me...

Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome.

BACKGROUND: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcription...

A rapid accurate approach to inferring pedigrees in endogamous populations.

Accurate reconstruction of pedigrees from genetic data remains a challenging problem. Many relationship categories (e.g. half-sibships versus avuncula...

Multiclassification of Colorectal Polyps from Colonoscopy Images Using AI for Early Diagnosis.

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, emphasizing the critical need for the accurate class...

Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease.

INTRODUCTION: Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a cruc...

Multi-Steroid Profiling and Machine Learning Reveal Androgens as Candidate Biomarkers for Endometrial Cancer Diagnosis: A Case-Control Study.

OBJECTIVE: To evaluate the diagnostic and prognostic potential of preoperative serum steroid levels in endometrial cancer (EC) alone and in combinatio...

Cocaine-Induced Apoplexy of a GH-Secreting Pituitary Tumor.

A 25-year-old previously healthy man presents to the clinic with a severe headache after cocaine consumption. Physical examination revealed acromegalo...

Learning a deep language model for microbiomes: The power of large scale unlabeled microbiome data.

We use open source human gut microbiome data to learn a microbial "language" model by adapting techniques from Natural Language Processing (NLP). Our ...

Artificial intelligence and colorectal neoplasia detection performances in patients with positive fecal immunochemical test: Meta-analysis and systematic review.

OBJECTIVES: The combination of fecal immunochemical test (FIT) followed by colonoscopy has established itself as one of the preferred population-based...

Deep neural networks reveal organic pollutants' dominance in global inflammatory bowel disease.

Inflammatory bowel disease (IBD) is increasing globally, with risk factors still poorly understood and influenced by both genetic and environmental fa...