Inflammatory Bowel Disease

The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.

N: (1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), a tire rubber antioxidant deri...

Transdermal delivery of biologics.

Biologics, including peptides, proteins, antibodies, vaccines and nucleic acid-based therapeutics, h...

Novel indicator for colonoscopy insertion difficulty and its application in predictive modelling: a multicentre prospective study protocol in China.

BACKGROUND: Colonoscopy is a cornerstone for the screening and diagnosis of colorectal diseases. Col...

Recent progress in clinical and molecular biological research in rectal serrated lesions.

Colorectal cancer ranks among the most common malignancies worldwide. Rectal serrated lesions repres...

Perioperative predictors of biochemical remission in acromegaly: a predictive modeling study.

PURPOSE: Biochemical remission after transsphenoidal resection for acromegaly remains challenging, a...

Automation dependence in AI-assisted colonoscopy: impact of system reliability and surgeon experience on navigation performance.

BACKGROUND: As artificial intelligence (AI) is increasingly introduced into endoscopic navigation, u...

The High-Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration.

The lumbar intervertebral disc high-intensity zone (HIZ), a focal hyperintensity within the annulus ...

The effectiveness of adding on or switching antiseizure medications after the first fails to control focal epilepsy: A systematic review of randomized controlled trials.

Focal epilepsy constitutes 60-70% of epilepsy, and up to half of patients do not achieve seizure fre...

AI-enabled lyophilization of advanced biologics: process intelligence, quality assessment, and formulation opportunities.

Lyophilization is a key stabilization strategy for advanced biologics, including protein therapeutic...

Epitope-Specific IgE Profiles are Predictive of Desensitization and Remission in the IMPACT Trial.

BACKGROUND: Results from the IMPACT trial suggest that initiation of peanut oral immunotherapy (pnOI...

[Sarcoidosis-associated uveitis: Current status and future prospects].

Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at ...

Real-World Evidence-Based Study on Treatment-Free Remission in Chronic Myeloid Leukemia.

BACKGROUND: Treatment-free remission (TFR) has become a treatment goal for chronic myeloid leukemia ...

Rethinking aging biomarkers in HIV: from measures to meaning.

PURPOSE OF REVIEW: People with HIV (PWH) on effective antiretroviral therapy continue to experience ...

The VISION-AI Trial: protocol for a pragmatic randomized controlled non-inferiority trial comparing artificial intelligence-guided colonoscopy to pancolonic chromoendoscopy for neoplasia detection in adults with colorectal inflammatory bowel disease.

BACKGROUND: Current guidelines recommend pancolonic chromoendoscopy (pCE) over white light endoscopy...

Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial.

BACKGROUND: Artificial intelligence (AI)-based computer-aided detection (CADe) systems improve adeno...

Human-artificial intelligence adaptation in colonoscopy: beyond deskilling and upskilling.

An efficient framework for real-time colorectal polyp detection using local outlier factor-based preprocessing and YOLOv11n.

Timely and accurate detection of colorectal polyps plays an important role in the prevention and ear...

Circulating multi-omic signature of disease severity and cholangiocarcinoma in primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associ...

Current and Novel Biomarkers for Diagnosis and Subtyping of Primary Aldosteronism.

Primary aldosteronism is a common and potentially curable cause of secondary hypertension, yet it re...

Response-aware molecular subtyping of ulcerative colitis for patient stratification via interpretable machine learning.

Ulcerative colitis (UC) is a heterogeneous inflammatory disease with diverse molecular features and ...

Use of an AI Image Recognition-Based Smartphone App in Personalized Bowel Preparation Before Colonoscopy: Prospective Randomized Controlled Trial.

BACKGROUND: Sufficient bowel preparation is critical for increasing the quality of colonoscopy. Howe...