Liver Transplantation

Toward Precise Risk Stratification after the Functional Cure of Chronic Hepatitis B.

Chronic hepatitis B remains a major global health challenge despite the advances in antiviral therapy. Although hepatitis B surface antigen (HBsAg) seroclearance is considered a functional cure, liver-related complications, particularly hepatocellular carcinoma, may still occur after viral clearance. This residual risk reflects the lasting impact of host and liver factors rather than ongoing viral...

Delisting From Clinical Improvement in Liver Cirrhosis: A Machine Learning Decision Tree Analysis.

BACKGROUND: Following therapeutic advancements, recompensation has gained increasing recognition in patients on waitlist for liver transplantation (LT). Identifying key predictors of waitlist removal because of improvement can enhance prognostication and resource allocation. We hence examined predictors of improvement-related waitlist removal using a machine learning-based approach with data from ...

Prediction of trajectories and outcomes in early-stage metabolic dysfunction-associated steatotic liver disease: a narrative review.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder, with manifestations ranging from steato...

Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

BACKGROUNDPrimary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine Bacillus Calmette-Guérin (BCG). Alt...

[Prevention in Gastroenterology].

Gastroenterology offers a broad, evidence-based range of preventive measures that goes beyond colorectal cancer screening. As a specialty of systemic ...

In vivo CAR-cell therapy: current challenges and emerging therapeutic advances.

In vivo chimeric antigen receptor (CAR) cell therapy is undergoing a transformative shift from conventional ex vivo manufacturing toward in situ cellu...

A Transformer-ResNet-Integrated Deep Learning Model for Digital Pathology-Based Grading and Risk Stratification of MASLD-Related Liver Fibrosis.

INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects up to 30% of the global population and drives progression to fi...

[Research progress in clinical pathology and molecular mechanisms of pancreatic adenosquamous carcinoma].

Pancreatic adenosquamous carcinoma (PASC) is a rare exocrine malignancy of the pancreas with an increasing incidence, histologically defined by the co...

Novel therapeutic strategies for metastatic castration‑resistant prostate cancer: Beyond androgen receptor pathway inhibition (Review).

Metastatic castration‑resistant prostate cancer (mCRPC) remains a lethal disease due to universal resistance to androgen‑receptor pathway inhibitors (...

Advances in HLA and Non-HLA Immune Profiling: Integrating Next-Generation Sequencing and Artificial Intelligence in Transplantation.

Understanding transplantation outcomes requires an integrated view of immunological, genetic, and clinical determinants that collectively shape graft ...

Exploring the potential targets and mechanisms of malachite green induced lung adenocarcinoma through network toxicology and molecular docking.

Malachite green (MG), a synthetic dye, has turned into a major risk to human health, because of its toxicity of teratogenic, genotoxic, carcinogenic, ...

AI-guided discovery of the IRF4-PAICS-LDHA axis as a multitarget hub linking tumor metabolism to CD8+ T cell exhaustion in DLBCL.

Diffuse large B-cell lymphoma (DLBCL) features an immunosuppressive tumor microenvironment (TME), yet the molecular drivers connecting metabolic repro...

Molecular Biomarkers and Risk Prediction Models for Acute Kidney Injury Following Liver Transplantation: A Review.

Liver transplantation is the definitive treatment for end-stage liver disease; however, postoperative acute kidney injury (AKI) affects 30%-70% of rec...

A review of traditional uses, phytoconstituents, bioactivities, and therapeutic potential of Hypecoum erectum L. and Hypecoum leptocarpum Hook.f. & Thomson.

ETHNOPHARMACOLOGICAL RELEVANCE: Hypecoi Erecti Herba, derived from plants of the genus Hypecoum (Papaveraceae), includes two source species: Hypecoum ...

Machine learning-based multi-omic analysis identifies CEP55, DLGAP5, and EZH2 as regulated cell death biomarkers linked to immunotherapy resistance in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) often exhibits limited responsiveness to immune checkpoint inhibitors (ICIs), largely due to an immunosuppressive tumor...

Contextualizing the Patient Blood Management (PBM) Program Through the Lens of Bioethical Principles.

In an increasingly specialized medical landscape, Patient Blood Management (PBM) has emerged as a multidisciplinary and ethically grounded approach to...

Personalized neoantigen cancer vaccines: Why clinical benefit remains inconsistent.

Personalized cancer vaccines have re-emerged as a promising strategy in precision immunotherapy, driven by advances in tumor sequencing, neoantigen id...

Regulatory B cells and SIVA1-LAG3 immune suppression predict poor prognosis in prostate cancer.

Prostate cancer (PCa) is among the most prevalent malignancies affecting men globally. The immunosuppressive characteristics of the tumor microenviron...

Efferocytosis-related biomarkers and immune infiltration in pancreatic ductal adenocarcinoma based on single-cell sequencing and machine learning: a comprehensive bioinformatics analysis and experimental validation.

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and lethal malignancy, with its complex tumor microenvironment (TME) severely...

Predicting hepatocellular carcinoma in people with hepatitis B: a comparison between Cox proportional hazard and machine learning models.

BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with chronic hepatitis B virus (HBV) infectio...