Rheumatology

Lupus

Latest AI and machine learning research in lupus for healthcare professionals.

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Dynamic changes in specific anti-L-asparaginase antibodies generation during acute lymphoblastic leukemia treatment.

BACKGROUND: L-asparaginase (L-asp) remains one of the key components of acute lymphoblastic leukemia therapy. Immune reactions to the drug are associated with its diminished activity. The aim of the study was to determine the level of IgM, IgG and IgE-class anti-L-asp antibodies during the induction and reinduction phases of acute lymphoblastic leukemia therapy and their influence on L-asp activit...

Nov 28 2018 30826572

Anti-microbial and anti-mycotoxigenic activities of endophytic isolated from (L.) G. Don.: molecular characterisation and bioactive compound isolation.

The present study investigated the anti-microbial and anti-mycotoxigenic activities of the ethyl acetate extract (EA) and a bioactive compound obtained from an endophytic fungus isolated from leaves. was identified using PCR-based 5.8S rDNA sequencing. The EA and bioactive compound, -Coumaric acid (PC), showed concentration-dependent broad-spectrum anti-microbial activity against the tested bac...

Nov 5 2018 30834151
A Randomized Control Trial Of Anti-Inflammatory Regional Hypothermia On Urinary Continence During Robot-Assisted Radical Prostatectomy.

The present study seeks to present a single-blind, randomized control trial of a hypothermic anti-inflammatory device, the endorectal cooling balloon ...

Nov 5 2018 30397236
Optimizing immune cell therapies with artificial intelligence.

PURPOSE: We determine an optimal injection pattern for anti-vascular endothelial growth factor (VEGF) and for the combination of anti-VEGF and unlicen...

Oct 22 2018 30352236
Anti-ulcer effect of Gallarhois extract with anti-oxidant activity in an ICR model of ethanol/hydrochloride acid-induced gastric injury.

Gallarhois (GR) is a traditional oriental herbal medicine with various pharmacological effects; however, its effect on gastric ulcer has not been prev...

Sep 28 2018 31453134
Bioactivity of semisynthetic eugenol derivatives against (Lepidoptera: Noctuidae) larvae infesting maize in Colombia.

The anti-acetylcholinesterase, larvicidal, antifeedant activities and general toxicity of 15 semisynthetic eugenol derivatives based on clove oil (inc...

Sep 27 2018 31762635
Therapeutic Enoxaparin in the Morbidly Obese Patient: A Case Report and Review of the Literature.

Enoxaparin is a low molecular weight heparin commonly used in the treatment of venous thromboembolisms (VTEs); however, evidence on optimal empiric do...

Sep 22 2018 31762484
anti-inflammatory and antimicrobial potential of leaf extract from (Clarke) Pamp.

In the present investigation, the bioactive compounds from the leaf extract of showed potent anti-inflammatory and antimicrobial activity. The leaf e...

Sep 18 2018 30899158
Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib.

Afatinib is an oral tyrosine kinase inhibitor (TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple qua...

Sep 18 2018 30740257
Predicting hospital readmission for lupus patients: An RNN-LSTM-based deep-learning methodology.

Hospital readmission is one of the critical metrics used for measuring the performance of hospitals. The HITECH Act imposes penalties when patients ar...

Aug 31 2018 30195164
Anti-microbial Activity of Aqueous Gall Extract against Pathogenic .

BACKGROUND: gall extract is known to have broad spectrum anti-microbial activity . This study was conducted to determine the anti-microbial activity ...

Aug 30 2018 30914846
Serum Transforming Growth Factor-Beta 1 Level in Egyptian Systemic Lupus Erythematosus Patients.

OBJECTIVES: This study aims to assess the role of transforming growth factor-beta 1 (TGF-β1) in systemic lupus erythematosus (SLE).

Jul 31 2018 30632531
Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.

Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel dr...

Jul 26 2018 30048526
Lupus nephritis pathology prediction with clinical indices.

Effective treatment of lupus nephritis and assessment of patient prognosis depend on accurate pathological classification and careful use of acute and...

Jul 6 2018 29980727
Achievements in robotic automation of solvent extraction and related approaches for bioanalysis of pharmaceuticals.

Currently, the growing demand on quick, easy and ecological sample pretreatment methods is unquestionable. Such challenge involves also approaches foc...

Jun 19 2018 29945105
Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests.

The impact of direct oral anticoagulants (DOACs) on laboratory assays used for thrombophilia testing (e.g., antithrombin, protein S, protein C, lupus ...

Jun 1 2018 31249943
PLGA Microspheres Loaded with β-Cyclodextrin Complexes of Epigallocatechin-3-Gallate for the Anti-Inflammatory Properties in Activated Microglial Cells.

Although epigallocatechin-3-gallate (EG) is well-known as a potent antioxidant and free radical scavenger for neurodegenerative diseases, it still has...

May 11 2018 30966553
In vitro Anti-cholinesterase and Anti-oxidant Activity of Three Standardised Polyherbal Products Used for Memory Enhancing in Ethnomedicine of South-East Nigeria.

BACKGROUND: Polyherbal standardised extracts used in ethnomedicine of Eastern Nigeria for memory improvements were evaluated for anti-cholinesterases ...

Apr 27 2018 30918453
Anti-synchronization of complex-valued memristor-based delayed neural networks.

This paper investigates the anti-synchronization of complex-valued memristor-based neural networks with time delays via designed external controllers....

Apr 25 2018 29758461
Structure-function properties of hypolipidemic peptides.

This review addresses the structure-function properties of hypolipidemic peptides. The cholesterol-lowering peptide (lactostatin: IIAEK) operates via ...

Mar 8 2018 31353491
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