Nephrology

Modulation of aldosterone levels by aldosterone synthase promoter polymorphism and association with eGFR decline in patients with chronic kidney disease.

To determine whether -344T/C CYP11B2 promoter polymorphism affects serum aldosterone levels and whether this polymorphism is an indicator of eGFR decline in patients with chronic kidney disease. -344 C/T CYP11B2 gene polymorphism analysis was performed in 96 adults with stages 1-5 CKD by using polymerase chain reaction. Serum aldosterone levels were measured at baseline and at 1.5-year follow-up. ...

Evaluation of the potential nephrotoxicity and mechanism in rats after long-term exposure to the traditional Tibetan medicine tsothel.

CONTEXT: Tsothel, a traditional Tibetan medicine, is regarded as 'the king of essences'. Nevertheless, tsothel has aroused serious concern regarding its biosafety because its main component is HgS. Unfortunately, toxicological studies on tsothel are scarce.

Risk factors for diastolic left ventricular myocardial dysfunction in patients with chronic kidney disease.

AIM: To examine the frequency and risk factors for the development of diastolic dysfunction (DD) of the left ventricle (LV) of the heart in patients w...

Do computers dream of electric glomeruli?

Predictive markers of depression in hypertension.

Hypertension and depression, as 2 major public health issues, are closely related. For patients having hypertension, in particular, depression is a ri...

The Development of a Machine Learning Inpatient Acute Kidney Injury Prediction Model.

OBJECTIVES: To develop an acute kidney injury risk prediction model using electronic health record data for longitudinal use in hospitalized patients.

Cardiorenal Outcomes in the CANVAS, DECLARE-TIMI 58, and EMPA-REG OUTCOME Trials: A Systematic Review.

In this systematic review, we sought to summarize the 3 recent sodium-glucose cotransporter 2 inhibitor (SGLT2i) trials (Dapagliflozin Effect on Cardi...

[Comparison of machine learning method and logistic regression model in prediction of acute kidney injury in severely burned patients].

To build risk prediction models for acute kidney injury (AKI) in severely burned patients, and to compare the prediction performance of machine learn...

Renal Function Estimates and Dosing of Direct Oral Anticoagulants in Stroke Patients with Atrial Fibrillation: An Observational Study.

PURPOSE: Appropriate dosing of direct oral anticoagulants (DOACs) requires consideration of renal function. Discordance between commonly used estimate...

Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online.

BACKGROUND: Immunosuppressant Bayesian dose adjustment (ISBA) is an online expert system, routinely used by approximately 140 transplantation centers ...

Effect of intraoperative mannitol administration on acute kidney injury after robot-assisted laparoscopic radical prostatectomy: A propensity score matching analysis.

Mannitol, an osmotic diuretic, has been used to prevent acute kidney injury (AKI). However, studies have found divergent effects of intraoperative man...

D-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology.

Male broiler breeders (n=32) of 55 weeks of age were administered four different doses of capsulated d-aspartate (DA; 0, 100, 200 or 300mgkg-1day-1, p...

Hookworm Detection in Wireless Capsule Endoscopy Images With Deep Learning.

As one of the most common human helminths, hookworm is a leading cause of maternal and child morbidity, which seriously threatens human health. Recent...

[Technical advancement in surgical treatment of portal hypertension].

Recently, there have been many developments and improvements in portal hypertension surgery, but there are still many controversies regarding the surg...

[Application of support vector machine in predicting in-hospital mortality risk of patients with acute kidney injury in ICU].

OBJECTIVE: To construct an in-hospital mortality prediction model for patients with acute kidney injury (AKI) in intensive care unit (ICU) by using su...

[Standard surgery for small renal masses (<4 cm)].

BACKGROUND: Several new treatment strategies have emerged in the treatment of small renal masses (<4 cm in diameter). Active surveillance and ablative...

[The gender features of disorders of composition of lipids of blood serum in patients with chronic pathology of kidneys.].

The purpose of the study was to investigate gender features of abnormalities of blood serum lipid composition and their relationship with clinical and...

Prevalence of latent Mycobacterium tuberculosis infection in renal transplant recipients.

OBJECTIVE: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemograp...

Correlation of Parathyroid Hormone Levels with Mineral Status in End-stage Renal Disease Patients.

UNLABELLED: Parathyroid hormone (PTH) is the main regulator of calcium, phosphate, magnesium, sodium, and potassium homeostasis. Therefore, this study...

NUTRITIONAL OR ACTIVE VITAMIN D FOR THE CORRECTION OF MINERAL METABOLISM ABNORMALITIES IN NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS?

CONTEXT: Benefits of vitamin D therapies in chronic kidney disease (CKD) are debated.