Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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AUBADE-syn: a novel deep learning ensemble method for glaucoma detection using synthetic fundus images on imbalanced datasets.

Glaucoma is the leading cause of irreversible blindness worldwide. Early detection is essential to preserve vision. Deep learning approaches have shown promise in automating glaucoma detection. However, significant class imbalance in medical datasets often impairs classifier performance. To address this challenge, we propose AUBADE-syn, a deep learning ensemble framework that integrates synthetic ...

May 14 2026 42135460

Identification of key genes related to macrophages and metabolic reprogramming in myocardial infarct based on single-cell and bulk transcriptomics data and experimental validation.

BACKGROUND: Myocardial infarction (MI), one of the most severe cardiovascular diseases, is influenced by altered macrophage status and metabolic reprogramming (MR), yet the mechanisms of their crosstalk remain unclear. This study used bioinformatics to explore key genes associated with macrophages and MR function in MI. METHODS: Single-cell and bulk transcriptomics data of MI were obtained from pu...

May 14 2026 42135635
Inflammatory-neurodegenerative crosstalk in pediatric severe traumatic brain injury: a multi-domain plasma proteomic study.

BACKGROUND: Pediatric severe traumatic brain injury (sTBI) remains a leading cause of death and long-term disability, yet its molecular characterizati...

May 14 2026 42135641
An integrated multi-variable optimization approach to tailor ankle-foot orthosis stiffness to end-user needs.

BACKGROUND: Ankle foot orthosis (AFOs) are devices commonly prescribed to assist or rehabilitate gait. A critical parameter influencing their effectiv...

May 14 2026 42135709
Identification of Mitochondrial Dysfunction-Related Candidate Biomarkers and Analysis of the Immune Cell Infiltration in Epilepsy.

Epilepsy is a severe neurological disorder with complex pathogenesis. Mitochondrial dysfunction (MitD) is increasingly recognized as a key driver of e...

May 14 2026 42128965
Microfluidic co-culture system for synaptically segregated neural networks to explore astrocyte-driven neural pathology.

Investigating astrocyte-neuron communication in the absence of neuron-to-neuron signalling is challenging using traditional culture systems due to the...

May 14 2026 42129138
Machine learning combined with WGCNA reveals potential calcium uptake-associated biomarkers in Parkinson's disease.

BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterised by progressive loss of dopaminergic neurons in...

May 13 2026 42126032
Zero-shot arbitrary-scale super resolution in susceptibility-weighted imaging for cerebral microbleed analysis.

BACKGROUND AND OBJECTIVE: Susceptibility Weighted Imaging (SWI) plays a pivotal role in detecting cerebral microbleeds (CMBs), key biomarkers of vascu...

May 13 2026 42155350
ECG Signatures and Long-Term Ischemic Stroke Risk: A Deep Learning Analysis of 200,000 Patients.

BACKGROUND: Scalable risk stratification for ischemic stroke remains an unmet need. OBJECTIVES: In this study, the authors sought to assess whether de...

May 13 2026 42126358
Continuous-time causal distribution learning with identifiability for brain dynamic effective connectivity inference.

Dynamic effective connectivity (dEC) analysis provides an approach for revealing the causal mechanism of information transmission in human brain. Howe...

May 13 2026 42134283
Automatic multiple sclerosis lesion segmentation in the spinal cord using 3 T and 7 T MP2RAGE images.

PURPOSE: To develop a deep learning-based fully automated framework for segmenting multiple sclerosis (MS) lesions in the spinal cord (SC) using image...

May 13 2026 42173050
Dynamic brain states and molecular signatures in primary angle-closure glaucoma.

BACKGROUND: Primary angle-closure glaucoma (PACG) has traditionally been regarded as an ocular disorder, but accumulating evidence suggests broader ce...

May 13 2026 42066007
Adrenal gland dysfunction in males with cluster headache.

BACKGROUND: Cluster headache is associated with compensated hypogonadism in males, suggesting impaired testicular steroidogenesis. It is unknown if ad...

May 13 2026 42129617
Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study.

OBJECTIVES: This study investigated whether the coupling between cortical blood-oxygen-level-dependent (BOLD) signals and cerebrospinal fluid (CSF) fl...

May 13 2026 42129618
Artificial intelligence models in cerebral infarction: performance and applications in diagnosis, classification, grading, treatment, and disease course prediction-a systematic review.

Artificial intelligence (AI) holds significant promise for transforming cerebral infarction care, yet its real-world performance across the entire dis...

May 13 2026 42129749
Recent innovative approaches for drug delivery systems targeting cancer and CNS disorders.

Advancements in drug delivery systems (DDSs) have revolutionized pharmaceutical development by enhancing therapeutic precision, minimizing off-target ...

May 13 2026 42132781
EEG-Based Clustering Shows Distinct Separation of Chronic Pain Patients Before Spinal Cord Stimulation Surgery.

Chronic pain is associated with disrupted cortical activity, yet individual variability in these neural patterns remains poorly understood. Electroenc...

May 13 2026 42134463
TF-MCL: Time-frequency fusion and multi-domain cross-loss for self-supervised depression detection.

In recent years, there has been a notable increase in the use of supervised detection methods of major depressive disorder (MDD) based on electroencep...

May 13 2026 42066795
Insular morphological abnormalities in focal to bilateral tonic-clonic seizures.

PURPOSE: Focal to bilateral tonic-clonic seizures (FBTCS) is the most severe form of epileptic seizures, posing a major challenge in both management a...

May 13 2026 42126544
Hand Gesture Intention Detection Using sEMG and Transfer Learning in Stroke Survivors.

Surface electromyography (sEMG) has shown potential for intuitive control of wearable assistive technologies in individuals with motor impairments. Ho...

May 13 2026 42127067
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