Oncology/Hematology

Leukemia Diagnosis 2.0: Revolutionizing advanced and Futuristic Point-of-Care Detection and Monitoring.

Leukemia diagnostics have changed significantly because of the advancements in biosensor technologies that improve the early detection, sensitivity, and point-of-care capabilities. Traditional diagnostic methods have a solid foundation, but they have limitations in how highly invasive they are, their cost, and a significant time lapse in providing results, & lack of smartness/intelligence. This re...

Hypergraph Representations of Single-Cell RNA Sequencing Data for Improved Cell Clustering.

MOTIVATION: Single-cell RNA sequencing (scRNA-seq) data analysis is often performed using network projections that produce co-expression networks. These network-based algorithms are attractive because regulatory interactions are fundamentally network-based and there are many tools available for downstream analysis. However, most network-based approaches have two major limitations. First, they are ...

Potential of SERS and proteomics for biomarker detection in cancer cells.

This study investigates the use of quantitative LC-MS/MS-based proteomics and surface-enhanced Raman spectroscopy (SERS) for biomarker detection in cl...

AI-driven body composition atlas reveals its association with NSCLC immunotherapy outcome and molecular background: a multicenter study.

Although previous studies have linked body composition to immunotherapy efficacy, comprehensive multidimensional analyses with biological explanations...

Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease.

Dementia in Lewy body diseases (LBD) is common and arises through heterogeneous and incompletely understood pathways. Evidence suggests contributions ...

Radiation Dose Optimisation Through Artificial Intelligence (AI)-based Auto-Thorax Collimation.

INTRODUCTION: Artificial intelligence (AI) is increasingly adopted in digital radiography to enhance workflow efficiency, standardisation and support ...

ECG-Gated Retrospective Coronary CT Angiography With Deep Learning Reconstruction on 8-cm Detector CT Scanners: Pushing Radiation Dose Towards Prospective Acquisition on 16-cm Wide-Detector Scanners.

PURPOSE: Although 16-cm wide-detector CT scanners with prospective ECG-gating enable coronary artery imaging within a single cardiac cycle at a low ra...

Deep Learning Enables Pixel-Level Nanoparticle Distribution Mapping in Routine Histological Sections by Integrating Cancer Associated Fibroblasts Features.

The efficient accumulation and uniform distribution of nanomedicine within tumors are critical for achieving therapeutic outcomes. However, convention...

DWI-derived intratumoral, peritumoral, and habitat features for preoperative prediction of lymph node metastasis in early-stage cervical cancer using machine learning method.

OBJECTIVES: This study aimed to develop a novel radiomic model by incorporating features from both habitat subregions and peritumoral regions to preop...

Artificial intelligence and radiomics for pediatric brain tumor classification and molecular characterization: a systematic review.

BACKGROUND: Artificial intelligence (AI) and radiomics are increasingly applied in pediatric neuroradiology to enhance diagnostic precision. However, ...

A novel cuproptosis-related prognostic gene signature is identified by machine learning and integrative analyses in gliomas.

Recent studies have highlighted the impact of copper-induced cell death (cuproptosis) on cancer progression, prognosis, and treatment, but it remains ...

IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response.

Large scale sequencing efforts have defined up to 27 diagnostic entities in B-ALL, leaving few samples without subtype assignment. Extended genomic an...

Artificial Intelligence and Multiomics Beyond PSA Screening in African and Middle Eastern Prostate Cancer Patients.

Prostate cancer (PCa) remains a major global health burden, with incidence rising as populations age. The molecular, histological, and patient-specifi...

FDG-PET Medullary Total Tumor Volume Highlights High-Risk Newly Diagnosed Multiple Myeloma Patients in CASSIOPEIA Trial.

This study aimed to assess the prognostic value of medullary total metabolic tumor volume (mTMTV) derived from fluorodeoxyglucose-positron emission to...

Novel two-stage deep learning framework for automated pressure injury classification.

OBJECTIVE: The study aims to develop an artificial intelligence (AI) framework for automatic pressure injury (PI) staging directly from raw clinical i...

Identification of MHC ligands through allele-guided isolation combined with machine learning for improved MHC assignment using ARDisplay-I.

The isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for T cell-based immuno...

Etiologic diagnosis of seasonal allergic rhinitis supported by artificial intelligence: the @IT-2020 project.

BACKGROUND: A precise etiological diagnosis of seasonal allergic rhinitis (SAR) is essential for a tailored prescription of its only curative treatmen...

Advanced neuroimaging for central nervous system infections: when, where, how, and why?

PURPOSE OF REVIEW: Central nervous system (CNS) infections remain a major cause of morbidity and mortality worldwide, particularly in children, older ...

Artificial intelligence-assisted FTIR spectroscopy for hormone receptor subtyping in formalin-fixed breast Cancer tissues.

BACKGROUND: Determination of estrogen receptor (ER) and progesterone receptor (PR) status is critical for breast cancer subtyping and guiding endocrin...

Cervical cancer image analysis: Detection and segmentation using self-guided quantum GANs and musical chairs optimization.

The main cause of cervical cancer emerges from long-term Human Papillomavirus (HPV) infections damaging the cervix. The detection methods produced by ...