Gastroenterology

Pancreatic Diseases

Latest AI and machine learning research in pancreatic diseases for healthcare professionals.

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A Brain Age Residual Biomarker (BARB): Leveraging MRI-Based Models to Detect Latent Health Conditions in U.S. Veterans

Age prediction using brain imaging, such as MRIs, has achieved promising results, with several studies identifying the model's residual as a potential biomarker for chronic disease states. In this study, we developed a brain age predictive model using a dataset of 1,220 U.S. veterans (18--80 years) and convolutional neural networks (CNNs) trained on two-dimensional slices of axial T2-weighted fa...

RadGPT: Constructing 3D Image-Text Tumor Datasets

With over 85 million CT scans performed annually in the United States, creating tumor-related reports is a challenging and time-consuming task for radiologists. To address this need, we present RadGPT, an Anatomy-Aware Vision-Language AI Agent for generating detailed reports from CT scans. RadGPT first segments tumors, including benign cysts and malignant tumors, and their surrounding anatomical...

ScaleMAI: Accelerating the Development of Trusted Datasets and AI Models

Building trusted datasets is critical for transparent and responsible Medical AI (MAI) research, but creating even small, high-quality datasets can ...

ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer

Pancreatic cancer (PC) patient-derived organoids (PDOs) faithfully recapitulate therapeutic responses but face clinical translation barriers, includin...

Generating Bounded Linear Temporal Logic in Systems Biology with Large Language Models

In computational modeling, Bounded Linear Temporal Logic (BLTL) is a valuable formalism for describing and verifying the temporal behavior of biologic...

Astrocyte-Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

Bionic implants are increasingly used to restore neural function yet achieving a chronically stable neural interface remains challenging. Biohybrid ne...

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

While extensive efforts have characterized lymphoid populations that contribute to pancreatic ‘insulitis’ in type 1 diabetes, significant gaps remain ...

Discovery and performance of DNA methylation panels for cancer detection and classification in blood

Examining DNA in a liquid biopsy for non-invasive cancer detection relies on identifying dilute signal in a high background. This study aims to identi...

Single-cell proteomics of pancreatic islet cells reveals type 1 diabetes and donor-specific features

Type 1 diabetes mellitus (T1DM) is the most common severe chronic disease in children and adolescents and requires life-long exogenous insulin treatme...

Phenotypic AI-based design of cell-specific small molecule cytotoxics

Drug discovery is being transformed by artificial intelligence, which enables the exploration of vast chemical spaces and the generation of novel comp...

Multi-Class Classification of Cannabis and Alcohol Use Disorder: Identifying Common and Substance-Specific Neural Circuits

Machine learning approaches have advanced the identification of neural signatures of substance use, particularly through case-control comparisons and ...

Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice

The prefrontal cortex (PFC) is one of the last brain regions to fully mature, making it particularly sensitive to drug use early in life. Both human a...

DeepSpot2Cell: Predicting Virtual Single-Cell Spatial Transcriptomics from H&E images using Spot-Level Supervision

Spot-based spatial transcriptomics (ST) technologies like 10x Visium quantify genome-wide gene expression and preserve spatial tissue organization. Ho...

Disentangling covariate effects on single cell-resolved epigenomes with DeepDive

Understanding the effects of individual biological factors from single cell-resolved epigenomic data is hindered by multicollinearity, particularly in...

AI-Driven and 3D-Bioprinted New Approach Methodology (NAM) Identifies NEO100 as Potent Ultrasound-Activated Therapeutic for Primary and Metastatic Brain Tumors

Primary and metastatic brain tumors are among the deadliest and treatment-resistant cancers, mainly because of their inherent resistance to chemoradia...

A large language model for predicting pancreatic ductal adenocarcinoma patients from blood-derived exosomal transcriptomics data

Traditional machine learning approaches for text or sequence classification rely on converting textual data into numerical representations. In this st...

Comparative Analysis of Pathology Foundation Models for Automated Detection of Tertiary Lymphoid Structures in H&E-Stained Digital Pathology Images

Tertiary lymphoid structures (TLS) have been observed in solid tumors and have been associated with better outcomes in patients treated with immunothe...

An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems

Complex multilineage organoid systems lack quantitative phenotyping methods preserving spatial architecture at high throughput. Current approaches com...

Using Large Language Models to Assemble, Audit, and Prioritize the Therapeutic Landscape

We present an AI-assisted pipeline for disease-specific drug landscape analysis. Given a disease name, the system assembles a comprehensive, evidence-...

Batch-Harmonized Machine Learning Framework for Cross-Cohort RNA Biomarker Discovery in Pancreatic Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) lacks reliable prognostic biomarkers. RNA-based signatures suffer from poor reproducibility due to batch effec...

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