Neurology

Parkinson's Disease

Latest AI and machine learning research in parkinson's disease for healthcare professionals.

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An attention-augmented multimodal classification of alzheimer's disease and parkinson's disease vs healthy controls using MRI, EEG, and SNP data.

Due to the late manifestation of structural symptoms and symptomatic overlap, neurodegenerative diseases such as Parkinson's Disease (PD) and Alzheimer's Disease (AD) remain difficult to diagnose accurately. In order to categorize AD and PD in comparison to Healthy Controls (HC), this study suggests a multimodal classification framework that combines genetic Single Nucleotide Polymorphism (SNP) da...

Jan 16 2026 41545552

Prompting and Fine-Tuning Large Language Models for Parkinson Disease Diagnosis: Comparative Evaluation Study Using the PPMI Structured Dataset.

BACKGROUND: Parkinson disease (PD) presents diagnostic challenges due to its heterogeneous motor and nonmotor manifestations. Traditional machine learning (ML) approaches have been evaluated on structured clinical variables. However, the diagnostic utility of large language models (LLMs) using natural language representations of structured clinical data remains underexplored. OBJECTIVE: This study...

Jan 15 2026 41539675
Co-occurrence patterns and related risk factors of dementia and Parkinson's disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis.

BACKGROUND: Dementia and Parkinson's disease (PD) are among the most prevalent neurological disorders globally. Most previous research has focused on ...

Jan 15 2026 41540403
Rigidity-driven tail extension controls interfacial thickness in polymer-nanoparticle composites.

We employ coarse-grained molecular dynamics simulations to investigate interfacial reorganization in polymer-nanoparticle composites, focusing on the ...

Jan 14 2026 41504269
Detection of parkinson's disease with neuroimaging modalities using machine learning and artificial intelligence: a systematic review.

The application of machine learning (ML) and artificial intelligence (AI) algorithms in medical imaging is an emerging area of interest, particularly ...

Jan 14 2026 41530502
Action tremor kinematics exhibit features of stabilization dysfunction in essential tremor patients.

BACKGROUND: Action tremor that begins with voluntary movement is a common manifestation of essential tremor (ET). We investigated a novel approach to ...

Jan 13 2026 41539533
CT-free attenuation and scatter correction of [11C]CFT brain PET using a Bi-directional matching network.

Quantitative PET imaging requires accurate attenuation and scatter correction (ASC), but the standard CT-based method introduces additional radiation ...

Jan 13 2026 41539466
Evolving approaches and data availability for understanding the impact of land-use change on ecosystem services.

Understanding how land-use change alters the flow of ecosystem services is critical for sustainability policy and planning. We conducted a systematic ...

Jan 13 2026 41534503
A causal bidirectional selective state space model for imaging genetics in neurodegenerative diseases.

Brain imaging genetics aims to uncover the pathological mechanisms and improve the diagnosis of brain diseases, particularly neurodegenerative disorde...

Jan 10 2026 41547121
Comprehensive Analysis of Autophagy-Related Gene Profiles and Immune Characteristics in Parkinson's Disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and α-synuclein pathology, yet the ro...

Jan 8 2026 41505625
Machine learning for automated differentiation of parkinson's disease and its mimics using ¹²³I-mIBG scintigraphy: insights from a multicentre real-world cohort (ITA-mIBG study).

PURPOSE: To assess machine learning (ML) classifiers trained on harmonised multicentre ¹²³I-mIBG planar scintigraphy for differentiating Parkinson's d...

Jan 2 2026 41483307
Cerebral hemodynamics and functional connectivity in the stroop test in Parkinson's disease patients: A machine learning approach to fNIRS features.

BACKGROUND: Cognitive impairment is a core non-motor feature of Parkinson's disease (PD). This study aimed to: (1) assess PD patients' performance on ...

Dec 31 2025 41494495
Deep learning-based cognitive impairment brain imaging analysis: New methods, new technologies, and new paradigms.

Cognitive impairment arising from ischemic stroke, Alzheimer's disease, and Parkinson's disease presents distinct structural and network-level alterat...

Dec 30 2025 42148603
Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease.

OBJECTIVE: This 24-month longitudinal study involving isolated rapid eye movement sleep behavior disorder (iRBD), early-stage Parkinson's disease (PD)...

Dec 30 2025 41467327
Deep Learning-Based Brainstem Segmentation and Multi-Class Classification for Parkinsonian Syndrome.

BACKGROUND: Brain segmentation using structural MRI is effective for identifying regional atrophy in Parkinsonian syndromes. However, clinical validat...

Dec 24 2025 41439587
Causal models and network instability in neurological and psychiatric disorders: Computational and clinical perspectives.

Self-diagnosis-the capacity of a system to detect and correct its own failures-is a defining property of adaptive systems. In the brain, recursive sel...

Dec 23 2025 41448497
Wirelessly transmitted subthalamic nucleus signals decode endogenous pain levels in Parkinson's disease patients.

Pain is a prominent non-motor symptom of Parkinson's disease (PD); it may appear in various levels (elevated or diminished) during waking hours and su...

Dec 22 2025 41443379
[Expert consensus on neurosurgical robot-assisted deep brain stimulation surgery (2026 edition)].

Robot-assisted deep brain stimulation (DBS) surgical systems in neurosurgery have demonstrated significant advantages in enhancing operative precision...

Dec 12 2025 41611273
Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia.

INTRODUCTION: Blood-based biomarkers that can aid diagnosis of Parkinson's Disease (PD) dementia (PDD), and predict PDD onset in people with PD are ur...

Dec 9 2025 41385896
Profiling the Braak progression in Parkinson's disease: a transcriptomics and ML driven identification of progressive biomarker and prognostic ceRNA signature.

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is marked by dopaminergic neuron loss and α-synuclein aggregation. Alt...

Dec 6 2025 41360364
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