Neurology

Parkinson's Disease

Latest AI and machine learning research in parkinson's disease for healthcare professionals.

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Parkinson's disease classification using gait analysis via deterministic learning.

Gait analysis plays an important role in maintaining the well-being of human mobility and health care, and is a valuable tool for obtaining quantitative information on motor deficits in Parkinson's disease (PD). In this paper, we propose a method to classify (diagnose) patients with PD and healthy control subjects using gait analysis via deterministic learning theory. The classification approach c...

Sep 28 2016 27693437

Multimodal Learning and Intelligent Prediction of Symptom Development in Individual Parkinson's Patients.

We still do not know how the brain and its computations are affected by nerve cell deaths and their compensatory learning processes, as these develop in neurodegenerative diseases (ND). Compensatory learning processes are ND symptoms usually observed at a point when the disease has already affected large parts of the brain. We can register symptoms of ND such as motor and/or mental disorders (deme...

Sep 14 2016 27649187
Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model.

Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain s...

Sep 13 2016 28113673
Serum Leptin Levels and Cognition in Parkinson's Disease Patients.

INTRODUCTION: To investigate the relationship between serum leptin levels and cognition in Parkinson's disease (PD) patients.

Sep 1 2016 28373801
Haptic Feedback Manipulation During Botulinum Toxin Injection Therapy for Focal Hand Dystonia Patients: A Possible New Assistive Strategy.

Abnormality of sensorimotor integration in the basal ganglia and cortex has been reported in the literature for patients with task-specific focal hand...

Aug 19 2016 27552765
Machine learning for large-scale wearable sensor data in Parkinson's disease: Concepts, promises, pitfalls, and futures.

For the treatment and monitoring of Parkinson's disease (PD) to be scientific, a key requirement is that measurement of disease stages and severity is...

Aug 8 2016 27501026
Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.

The brain enables animals to behaviorally adapt in order to survive in a complex and dynamic environment, but how reward-oriented behaviors are achiev...

Jul 21 2016 27493625
Basal Ganglia dysfunctions in movement disorders: What can be learned from computational simulations.

The basal ganglia are a complex neuronal system that is impaired in several movement disorders, including Parkinson's disease, Huntington's disease, a...

Jul 9 2016 27393040
Joint feature-sample selection and robust diagnosis of Parkinson's disease from MRI data.

Parkinson's disease (PD) is an overwhelming neurodegenerative disorder caused by deterioration of a neurotransmitter, known as dopamine. Lack of this ...

Jun 10 2016 27296013
Robust Machine Learning-Based Correction on Automatic Segmentation of the Cerebellum and Brainstem.

Automated segmentation is a useful method for studying large brain structures such as the cerebellum and brainstem. However, automated segmentation ma...

May 23 2016 27213683
Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease.

BACKGROUND: Brain MRI holds promise to gauge different aspects of Parkinson's disease (PD)-related pathological changes. Its analysis, however, is hin...

Apr 19 2016 27102045
Test and Validation of a Smart Exercise Bike for Motor Rehabilitation in Individuals With Parkinson's Disease.

To assess and validate the Smart Exercise Bike designed for Parkinson's Disease (PD) rehabilitation, 47 individuals with PD were randomly assigned to ...

Mar 31 2016 27046905
Symmetry Analysis of Gait between Left and Right Limb Using Cross-Fuzzy Entropy.

The purpose of this paper is the investigation of gait symmetry problem by using cross-fuzzy entropy (C-FuzzyEn), which is a recently proposed cross e...

Feb 24 2016 27034706
A Q-backpropagated time delay neural network for diagnosing severity of gait disturbances in Parkinson's disease.

Parkinson's disease (PD) is a movement disorder that affects the patient's nervous system and health-care applications mostly uses wearable sensors to...

Feb 2 2016 26850352
Robotic gait rehabilitation and substitution devices in neurological disorders: where are we now?

Gait abnormalities following neurological disorders are often disabling, negatively affecting patients' quality of life. Therefore, regaining of walki...

Jan 18 2016 26781943
Closed-Loop Modulation of the Pathological Disorders of the Basal Ganglia Network.

A generalized predictive closed-loop control strategy to improve the basal ganglia activity patterns in Parkinson's disease (PD) is explored in this p...

Jan 13 2016 26766381
Diagnosing Parkinson's Diseases Using Fuzzy Neural System.

This study presents the design of the recognition system that will discriminate between healthy people and people with Parkinson's disease. A diagnosi...

Jan 10 2016 26881009
Protective Effects of Streblus asper Leaf Extract on H2O2-Induced ROS in SK-N-SH Cells and MPTP-Induced Parkinson's Disease-Like Symptoms in C57BL/6 Mouse.

This study investigated the effects of Streblus asper leaf extract (SA) on reactive oxygen species (ROS) in SK-N-SH cell culture and on motor function...

Dec 21 2015 26798403
Measurement of viral load by the automated Abbott real-time HIV-1 assay using dried blood spots collected and processed in Malawi and Mozambique.

BACKGROUND: The use of dried blood spots (DBS) for HIV-1 viral load quantification can greatly improve access to viral monitoring for HIV-infected pat...

Nov 8 2015 26792161
Computer-Aided Diagnosis of Parkinson's Disease Using Enhanced Probabilistic Neural Network.

Early and accurate diagnosis of Parkinson's disease (PD) remains challenging. Neuropathological studies using brain bank specimens have estimated that...

Sep 29 2015 26420585
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