Neurology

Parkinson's Disease

Latest AI and machine learning research in parkinson's disease for healthcare professionals.

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Fingerprint-Based Explainable Machine Learning for Predicting Blood–Brain Barrier Permeability

Predicting blood–brain barrier (BBB) permeability is essential for early central nervous system (CNS...

Hierarchical Coarse-to-Fine cGAN for Subtype-Specific Freezing of Gait Signal Generation

Freezing of gait (FOG), a debilitating symptom of Parkinson’s disease, manifests in subtypes as shuf...

Tissue Reassembly with Generative AI

The spatial arrangement of cells is fundamental to their function, but single-cell RNA sequencing lo...

Leveraging Deep Learning and MD Simulations to Decipher the Molecular Basis of Attenuated Activity in Glycocin F

The escalating crisis of multi-drug resistant bacteria demand a new generation of antibiotics. Glyco...

Feature-Mask-Based Strategies for Subtype-Specific Freezing of Gait Detection using CNNs

Freezing of gait (FOG), a disabling symptom of Parkinson’s disease, varies in manifestations and mot...

Neural Underpinnings of Olfactory Dysfunction across Parkinson’s and Alzheimer’s Spectra

Olfactory dysfunction is a frequent yet understudied feature of neurodegenerative spectrum disorders...

REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

Sleep disturbances have been shown to be intimately and bidirectionally related to disease progressi...

Cingulate-centered flexible control: physiologic correlates and enhancement by internal capsule stimulation

The flexible deployment of cognitive control is essential for adaptive functioning in dynamic enviro...

Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal Cilia

Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal...

Comparative Single-Cell Transcriptomics Uncovers Shared and Distinct Molecular Signatures in Cystic Fibrosis and Primary Ciliary Dyskinesia

Cystic Fibrosis (CF) and Primary Ciliary Dyskinesia (PCD) are both inherited respiratory disorders t...

ProCyon: A multimodal foundation model for protein phenotypes

Characterizing human proteins remains a major challenge: approximately 29% of human proteins lack ex...

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson’s disease

Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Pa...

Muscle activation prediction in essential tremor through neuromusculoskeletal digital twinning and deep neural networks

Essential tremor (ET) is the most common movement disorder in adults, affecting up to 5% of the popu...

Designing Convergent Overlapping Genes with Transformer Encoder Models and Lightweight Structural Proxies

Overlapping genes allow multiple proteins to be encoded from a single DNA sequence, including conver...

Explainable 3D CNNs link regional and network level disruption in early Parkinson’s MRIs to symptom progression

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder affecting approximately 1% of t...

Cross-species etiologically informed stratification enables T cell receptor-based diagnosis of Parkinson’s Disease

Developing peripheral blood-based diagnostic models for idiopathic Parkinson’s disease (iPD), partic...

Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex

Recent advances in deep brain stimulation (DBS) of the subcallosal cingulate (SCC) show promise in m...

Exploring Stress-Induced Neural Circuit Remodeling through Data-Driven Analysis and Artificial Neural Network Simulation

Chronic stress induces behavioral rigidity and neural circuit remodeling, yet the underlying computa...

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