Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Enhancing urothelial carcinoma diagnosis with artificial intelligence-integrated urine cytology: Biopsy-validated accuracy and efficiency gain.

BACKGROUND: Urine cytology is a noninvasive tool for detecting urothelial carcinoma, yet its performance depends heavily on expert cytologists and time-intensive glass slide review. Artificial intelligence (AI)-assisted digital cytology has emerged as a potential solution to improve diagnostic sensitivity and workflow efficiency. This retrospective study aimed to evaluate the diagnostic performanc...

Jun 1 2026 42144873

MALICoT: A pilot cross-sectional study analyzing the effects of power training and age on endomysium content and fiber area in the soleus muscle of adult males.

The cross-sectional Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) examined effects of athletic exercise and age on endomysium content in human soleus muscle. Forty-three clinically healthy male participants were grouped into young (20-35 years) nonphysically active controls (n = 12), young power-trained athletes (n = 10), older (60-75 years) nonphysica...

Jun 1 2026 42210728
Assessing Delay Patterns in Diagnosis and Care Among Breast Cancer Patients in Ethiopia.

BACKGROUND: In Ethiopia, breast cancer patients often present with advanced-stage disease, leading to high mortality. This study aimed to quantify dia...

Jun 1 2026 42219283
Development of an exploratory prediction model for preoperative CK19 expression in esophageal cancer driven by radiomics and machine learning.

BACKGROUND: Esophageal cancer ranks among the most lethal malignancies worldwide, particularly prevalent in the Guangdong-Chaoshan region of China due...

Jun 1 2026 42224263
Automatic framework for PD-L1 expression evaluation in Latino patients with non-small cell lung cancer.

Programmed death ligand-1 (PD-L1) expression is a key biomarker for identifying non-small cell lung cancer (NSCLC) patients eligible for immunotherapy...

May 31 2026 42389203
Molecular Engineering of the Nano-Bio Interface for Programmable and Precision Protein Delivery.

Protein therapeutics offer unparalleled specificity and immediate bioactivity for addressing complex pathologies; however, their vast therapeutic pote...

May 31 2026 42219943
Integrated Network Pharmacology, Molecular Docking, and Experimental Validation for Uncovering the Pharmacodynamic Basis of Sanghuang against Human Pulmonary Fibrosis.

INTRODUCTION/OBJECTIVE: Sanghuang, a traditional Chinese medicinal fungus, exhibits well-documented anti-inflammatory, antioxidant, and antitumor acti...

May 31 2026 42220119
Rapid autofluorescence based 3D optical imaging of the pancreatic cancer milieu at mesoscopic scale - stain-free volumetric segmentation.

Although major advances have been made in the field of mesoscopic imaging and associated tissue clearing protocols, these applications are greatly cha...

May 31 2026 42225812
Cancer workforce-a global crisis: a Lancet Oncology Commission.

The shortage of well-trained personnel to deliver cancer care and conduct research remains a major obstacle to reducing disparities in cancer survival...

May 31 2026 42218903
Evaluation of an Artificial Intelligence Language Model for Generating Informed Consent Forms in Oral and Maxillofacial Surgery: A QUEST Framework Analysis.

BACKGROUND: Informed consent is a core ethical and legal requirement in oral and maxillofacial surgery (OMFS). Traditional consent documents often lac...

May 30 2026 42528730
Quantitative MRI of pediatric chronic kidney disease and renal fibrosis: potential non-invasive clinical biomarkers.

Chronic kidney disease (CKD) in children is a rare but serious condition characterized by progressive renal dysfunction and a range of systemic compli...

May 30 2026 42216968
A lightweight deep learning model with channel attention for kidney cell classification from microscopy images.

Accurate identification of renal cell types within tissue architecture is fundamental for understanding normal kidney physiology and detecting early p...

May 30 2026 42218235
Automated leukemia detection from microscopic images using deep transfer learning with explainable AI-based analysis.

Leukemia, a life-threatening hematological malignancy, necessitates early and accurate diagnosis for effective treatment. Traditional microscopic exam...

May 30 2026 42218261
Extracellular vesicle and particle biomarkers in cancer: a machine learning blueprint for liquid biopsy.

The combination of machine learning and liquid biopsy is rapidly promoting the development of precision cancer diagnosis. Extracellular vesicles and p...

May 30 2026 42218435
A computational framework for patient-specific breast modelling with anatomically informed Cooper's ligament networks.

BACKGROUND: Cooper's ligaments tether the dermis to the pectoral fascia and play a key role in breast suspension, but they are still poorly represente...

May 29 2026 42275975
FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression.

Hypoxia is a hallmark of oral squamous cell carcinoma (OSCC) and plays a critical role in driving tumor progression. However, the mechanisms by which ...

May 29 2026 42212377
Artificial Intelligence in Oncology: Clinical Applications, Challenges, and Opportunities.

Artificial intelligence (AI) is reshaping cancer research and clinical oncology by enabling large-scale analysis of complex biomedical data. Although ...

May 29 2026 42214043
Proteomic and transcriptomic analyses identify the role of RBM25 in the malignant progression of glioma.

Glioma is a primary tumor derived from central nervous system glial cells. RNA binding motif protein 25 (RBM25) has been implicated in glioma progress...

May 29 2026 42216302
Enhydrin from yacon attenuates atherosclerosis by modulating the FABP5/PPARγ/ABCA1 axis: An integrated multi-omics and in vivo validation.

Dysregulated lipid metabolism drives atherosclerosis (AS). Yacon, an Andean lipid-modulating tuber, exerts anti-AS potential, but mechanisms remain un...

May 29 2026 42217667
Deep Learning-Based Diagnosis of Parotid Gland Tumors on CT Images: A Multi-view Approach for Preoperative Differentiation of Benign and Malignant Lesions.

BACKGROUND: Accurate preoperative differentiation between benign and malignant parotid gland tumors is essential for guiding surgical planning and tre...

May 29 2026 42217825
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