Pathology

AI triage of duodenal biopsies improves workflow.

AIMS: To develop, deploy and evaluate artificial intelligence (AI) for triaging duodenal biopsies within a National Health Service (NHS) histopathology laboratory, with the aim of improving reporting turnaround times for clinically significant diagnoses. METHODS: The pathway was developed in the UK in an NHS laboratory. Rule-based automation software was used to find all newly scanned duodenal bio...

Comparative Evaluation of 3D-QALAS Myelin Volume Fraction, Inhomogeneous Magnetization Transfer, and Myelin Water Fraction.

BACKGROUND AND PURPOSE: Accurate in vivo quantification of myelin remains challenging despite advances in MRI. We evaluated three-dimensional synthetic MRI-derived myelin volume fraction from three-dimensional quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) by comparing it with inhomogeneous magnetization transfer ratio, myelin water fracti...

A deep learning-based digital biopsy for predicting early recurrence in gastric cancer.

Early postoperative recurrence is a major cause of treatment failure in patients with locally advanced gastric cancer (LAGC), yet current staging syst...

FT-MDNNMDs: early detection of breast cancer using fine-tuned multi-deep neural networks with TCGA and clinical image datasets.

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Early and accurate detection is critical for improv...

AI-Generated Clinical Images of Head-and-Neck Lesions in Plastic Surgery Education: An Expert Evaluation.

BACKGROUND: Clinical images are essential in plastic and reconstructive surgery education, particularly for understanding pathology, planning reconstr...

Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes.

Mammalian oocytes store proteins for embryonic development on abundant structures known as cytoplasmic lattices (CPLs)1; however, the mechanisms by wh...

Malignant Cerebral Edema after Large-Core Anterior Circulation Stroke in the Thrombectomy Era: Prediction and Neurocritical Care Pathways.

Large-core anterior circulation ischemic stroke (LCIS) complicated by malignant cerebral edema (MCE) remains a leading cause of early death and profou...

Convergence of multiplexed immunosensors, nanotechnology, and AI for early pancreatic cancer diagnosis.

Pancreatic cancer (PC) remains one of the deadliest malignancies, largely because of its asymptomatic onset, rapid progression, and absence of sensiti...

Multi-site validation of an AI-based biomarker test for determining ER, PR, and HER2 status from H&E-stained breast cancer slides.

BACKGROUND: The assessment of estrogen/progesterone receptors (ER/PR) and human epidermal growth factor receptor 2 (HER2) is essential for managing br...

Deep Learning-Based Multimodal Fusion of Ultrasound, Cytology, and Clinical Features to Distinguish Follicular Thyroid Carcinoma from Adenoma: A Multicenter Study.

RATIONALE AND OBJECTIVES: Preoperative differentiation between follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) remains challen...

Imaging Immune Heterogeneity in Nasopharyngeal Carcinoma: A Multidimensional Radiomics Perspective.

RATIONALE AND OBJECTIVES: Nasopharyngeal carcinoma (NPC) is characterized by a distinctive virologic and immunologic profile, in which Epstein-Barr vi...

Multimodal large language models in brain tumor imaging: clinical applications and future perspectives.

The use of multimodal data is essential for the precise diagnosis and treatment of brain tumors. In this context, multimodal data encompass multiseque...

Multiclass Classification of Renal Tumor Subtypes: Addressing Diagnostic Challenges Using a Texture-Informed Deep Hybrid CNN-Transformer.

Accurate histopathological classification of renal cell carcinoma (RCC), along with its distinction from benign mimickers, is essential for precision ...

Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative.

We present a large whole-body and total-body curated dataset of dual-modality 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Compu...

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment.

BACKGROUND: Accurate prediction of early recurrence (ER) after radical resection remains a critical challenge in pancreatic ductal adenocarcinoma (PDA...

Robotic Pancreaticoduodenectomy with Right Lateral Approach to the Superior Mesenteric Artery: Surgical Artificial Intelligence-Based Visualization for Standardized Dissection.

BACKGROUND: Robotic pancreaticoduodenectomy enables precise vascular dissection, but dissection of the superior mesenteric artery (SMA) remains techni...

Soft multiclass feature augmented deep learning to predict tumor origins using cytology or histology whole slide images.

Tailoring cancer treatment to the primary tumor site is essential for optimal outcomes, yet identifying the source of metastasis remains a significant...

Molecular polarizability as the universal driver of HPAH fate: Evidence from DFT-validated machine learning.

A DFT-explainable machine-learning (DFT-XML) strategy integrated with an active learning mechanism was proposed and validated to connect quantum-level...

Bone Magnetic Resonance Imaging: From Conventional Methods to AI-Driven Solutions.

With global population aging and increased life expectancy, bone diseases affect a substantial proportion of individuals worldwide, imposing a signifi...

Wooden-Tip Electrospray Ionization Mass Spectrometry Combined With Machine Learning for Differentiating Thyroid Tumours.

Direct mass spectrometry (MS) analysis of human tissues at the molecular level has great potential for clinical diagnosis and biomarker discovery. How...