Peptic Ulcer Disease

Recent advances in synthetic virtual 3D endoscopy to assist in skull base surgery.

INTRODUCTION: The advent of the operating microscope revolutionized neurosurgery by introducing stereoscopic visualization and enabling microneurosurgery. Endoscopy, in turn, brought a compact, wide-angle view through minimal access corridors but sacrificed depth perception. Although 3D endoscopes partially restore stereopsis, they remain costly and hardware dependent. Synthetic or virtual 3D endo...

Study of bladder cancer detection in standard white light versus AI-supported endoscopy-01 (RAISE-01) - Development and validation of an AI-based support tool.

BACKGROUND: Diagnosis and surveillance of bladder cancer rely on white-light cystoscopy (WLC). However, this modality is operator-dependent and associated with a risk of missed lesions, contributing to high recurrence rates, especially in non-muscle invasive bladder cancer. Recent advances in artificial intelligence (AI) enable software-based decision support for bladder lesion detection, with pot...

Identification of mitochondrial dynamics-related biomarkers in psoriasis using bioinformatics and Mendelian randomization.

Mitochondrial dynamics (MD) are crucial in various inflammatory disorders, yet the specific mechanisms involved in psoriasis remain inadequately under...

Multi-omics investigation of benzo[a]pyrene in gastric cancer: comprehensive network toxicology, machine learning and molecular docking approaches.

Gastric cancer (GC) risk is shaped by environmental exposures such as benzo[a]pyrene (BaP). Here, we systematically identified BaP-toxicological targe...

Machine learning and free energy clustering reveal PAH protein binding linked to AD risk.

This study develops a computational framework integrating bioinformatics, machine learning, and ΔG clustering to prioritize polycyclic aromatic hydroc...

Adherence to guidelines, pitfalls, and emerging technologies in endoscopic practice for celiac disease: a nationwide SIGENP survey.

UNLABELLED: Upper gastrointestinal endoscopy (UGIE) with duodenal biopsies remains the gold standard for diagnosing celiac disease (CD) in children an...

HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

Oxidative stress (OS) is a hallmark of Alzheimer's disease (AD), yet the cell type-specific mechanisms remain unclear. We analyzed a single-cell RNA s...

Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.

BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lackin...

Spatio-temporal characterization of gastric distensibility in upper endoscopy identifies the presence of Helicobacter pylori.

Assessment of gastric distensibility is crucial for understanding various gastrointestinal disorders, particularly those affecting gastric motility an...

Position Paper: IOlBD Evidence-based Consensus on the Use of Artificial Intelligence for Assessment of Endoscopic and Histologic Endpoints in Clinical Trials of Inflammatory Bowel Disease.

BACKGROUND & AIMS: Central reading of endoscopy and histopathology is the current standard for disease activity assessment in inflammatory bowel disea...

IMMT downregulation promotes osteoarthritis development by inducing mitochondrial dysfunction.

OBJECTIVE: This study aimed to identify key mitochondria-related genes involved in the pathogenesis of osteoarthritis (OA). METHODS: Publicly availabl...

Nitenpyram promotes breast cancer progression via PARP1: Integration of multi-omics analyses with experimental validation.

Nitenpyram (NIT) is an insecticide used primarily for flea control in pets, especially cats and dogs. Some studies suggest that NIT is associated with...

[Exploring the therapeutic targets and molecular mechanisms of pimecrolimus in the treatment of oral lichen planus based on network pharmacology, machine learning, and molecular docking].

Objective: To systematically investigate the potential targets and therapeutic mechanisms of pimecrolimus in the treatment of oral lichen planus (OLP)...

Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

BACKGROUND: Vancomycin-resistant Enterococcus (VRE) infection is a life-threatening complication after liver transplantation (LT). This study aimed to...

A confidence-based, artificial intelligence pathology model for diagnosis of intrahepatic cholangiocarcinoma.

BACKGROUND: Intrahepatic cholangiocarcinoma (ICCA) is a rare but highly lethal adenocarcinoma arising within the hepatic parenchyma. Diagnosis present...

Phenotypic clustering of myocardial infarction complicated by out-of-hospital cardiac arrest using unsupervised machine learning.

BACKGROUND: Patients with myocardial infarction (MI) complicated by out-of-hospital cardiac arrest (OHCA) represent a heterogeneous population with va...

Identifying patients at risk for short-term adverse events after hip arthroscopy: a machine learning analysis of a national database.

PURPOSE: To develop and compare machine learning-based risk prediction models to identify patients at risk for short-term adverse outcomes (overnight ...

Human-in-the-loop validation of an artificial intelligence-driven real-time prostatic capsule recognition model for nerve-sparing robot-assisted radical prostatectomy.

BACKGROUND: Nerve-sparing robot-assisted radical prostatectomy (NS-RARP) requires precise prostatic capsule identification to balance oncological cont...

Identifying Shared Diagnostic Genes and Underlying Mechanisms Between Skin Exposure to Air Pollution and Skin Barrier Damage: A Bioinformatics Approach.

Air pollution poses a significant threat to skin health, contributing to inflammation, aging, and disruption of the epidermal barrier. This study aims...

Artificial intelligence for automated detection of joint bleeding via ultrasound in hemophilia: advancing standardization.

BACKGROUND: Musculoskeletal ultrasound (US) is a noninvasive tool for joint assessment in persons with hemophilia. Early detection of joint bleeding u...