Gastroenterology

Peptic Ulcer Disease

Latest AI and machine learning research in peptic ulcer disease for healthcare professionals.

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HPInet: Interpretable prediction of Host-Pathogen protein-protein Interactions using a transformer-based neural network

Gram-negative bacteria utilize a series of secretion systems (T1SS-T10SS) to deliver secreted effect...

Decoding Helicobacter pylori Resistance: Machine Learning–Enhanced Prediction of Antibiotic Susceptibility using Whole-Genome Sequencing

Helicobacter pylori is a significant risk factor for gastric cancer, peptic ulcers, and MALT lymphom...

C3PI: Component Puzzle Protein-Protein Interaction Prediction

Proteins primarily perform their functions through interactions with other proteins, making the accu...

Improving Protein Interaction Prediction in GenPPi: A Novel Interaction Sampling Approach Preserving Network Topology

Computational prediction of protein-protein interactions (PPIs) is crucial for understanding cell bi...

In Silico Design of APOE ɛ4 Interaction Inhibitor Peptides for Alzheimer’s Disease

Protein-protein interactions (PPIs) are essential for cellular functions, and their aberrant formati...

Instruction-tuned extraction of virus-host interactions from integrated scientific evidence

Viral infectious diseases continue to pose a major threat to global health. Understanding protein-pr...

Protein-protein interaction priors shape biologically coherent latent spaces for causally concordant cross-omic translation

Deep learning models routinely compress omics into low-dimensional codes, yet many equally accurate ...

Multiplex mapping of protein-protein interaction interfaces

We describe peptide mapping through Split Antibiotic Resistance Complementation (SpARC-map), a metho...

GREmLN: A Cellular Graph Structure Aware Transcriptomics Foundation Model

The ever-increasing availability of large-scale single-cell profiles presents an opportunity to deve...

Protein Language Models are Accidental Taxonomists

Protein-protein interactions (PPIs) are fundamental to nearly all biological processes, yet their ex...

Discovery of molecular glues by modeling ternary complex conformational ensembles and thermodynamic stability

The rational design of molecular glue degraders is challenging because glue-mediated protein degrada...

Systematic discovery of single-cell protein networks in cancer with Shusi

Context-specific protein-protein interaction (PPI) drive heterogeneity of primary tumor, forming a f...

Language may be all omics needs: Harmonizing multimodal data for omics understanding with CellHermes

Decoding cellular systems requires integrating diverse omics data, yet most models are trained from ...

ProtAttn-QuadNet: An attention-based deep learning framework for protein–protein interaction prediction using ProtBERT embeddings

Protein–protein interactions (PPIs) form the backbone of most cellular processes, governing signal t...

MkAtt-SDN2GO: Multi-kernel Attentive-SDN2GO Network for Protein Function Prediction in Humans

Accurately annotating the functions of uncharacterised human proteins remains a major bottleneck in ...

BioPrediction-PPI: Simplifying the Prediction of Protein-Protein actions through Artificial Intelligence

Proteins are essential in biological processes, primarily through their interactions with other mole...

B-PPI: A Cross-Attention Model for Large-Scale Bacterial Protein-Protein Interaction Prediction

Protein-protein interactions (PPIs) are essential for the study of cellular function, yet computatio...

Mechanism-Aware Inductive Bias Enhances Generalization in Protein-Protein Interaction Prediction

Robust prediction of protein–protein interactions (PPIs) requires models that generalize beyond the ...

A flaw in using pre-trained pLLMs in protein-protein interaction inference models

With the growing pervasiveness of pre-trained protein large language models (pLLMs), pLLM-based meth...

A Context-Specific, Literature-Supported Framework for Validating Stress Response Models in Mammals

Computational models of stress responses can highlight candidate genes underlying physiological adap...

Assessing Inflammatory Protein Biomarkers in COPD Subjects with and without Alpha-1 Antitrypsin Deficiency

Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in C...

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