Psoriasis

Quality of Tinnitus Information From Generative AI Systems and Web Search: An Expert‑Rated Comparative Study.

OBJECTIVE: To compare the quality of tinnitus-related information generated by multiple generative artificial intelligence (GenAI) systems and web search using expert evaluation. STUDY DESIGN: Cross-sectional comparative study. SETTING: Digital platforms evaluated in their native public interfaces. PATIENTS: Not applicable. Thirty commonly searched tinnitus-related questions derived from United St...

A Closed-Loop Framework for Inverse Design: Dynamic Training and Intelligent Optimization for Heterostructured Materials.

For decades, heterostructured materials have attracted great research interest because of their remarkable mechanical and physical properties. Nevertheless, exploring the immense design space to address the intrinsic trade-off between strength and toughness through trial-and-error experiments and simulation approaches entails considerable temporal and economic expenditures. Here, we propose a comp...

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis.

Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide. A mor...

Rethinking aging biomarkers in HIV: from measures to meaning.

PURPOSE OF REVIEW: People with HIV (PWH) on effective antiretroviral therapy continue to experience a disproportionate burden of age-related comorbidi...

Development of a predictive marker panel for the individualised bDMARD therapy of psoriatic arthritis: protocol for a prospective observational study (Integrate-PsA).

INTRODUCTION: Psoriatic arthritis is a chronic inflammatory disease that can affect the axial skeleton as well as the joints and enthesis. Following t...

Infection risk in rheumatoid arthritis patients treated with biologic and targeted synthetic DMARDs: prediction models and use of machine learning.

Infection risk is an important consideration during treatment decision-making in rheumatoid arthritis (RA), including at the initiation of biologics o...

Disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis after failure of biologic or targeted synthetic therapy: a systematic review and network meta-analysis.

RATIONALE: After inadequate response to first-line biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drug (DMARD) therapy in adult...

Comparative effectiveness of arthroscopic-assisted uniportal surgery versus percutaneous endoscopic decompression in lumbar spinal stenosis.

Single-level lumbar spinal stenosis (LSS) that does not respond to conservative therapy is now of the standard care given due to minimal invasive deco...

Transcriptomic characterization of key psoriasis-associated genes based on single-cell RNA-seq and machine learning.

BACKGROUND: Psoriasis is a multifaceted skin and systemic disorder driven by a complex interplay of genetic, immunological, and environmental factors....

Association between metal co-exposure and frailty: exploring the potential explanatory pathway of inflammation.

Frailty is a critical geriatric syndrome associated with disability and mortality, yet the associations and mechanisms between environmental metal co-...

Dorsiventrally Bicolored Leaf-Inspired Metamaterial Absorbers for Tailorable Electromagnetic Absorption.

Realizing tailorable broadband electromagnetic absorption within structurally concise architectures remains a key challenge for advanced absorber desi...

Artificial Intelligence for Evidence Synthesis of Emerging Biologics to Improve Skeletal Health in Osteogenesis Imperfecta: Systematic Review and Meta-Analysis.

BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by bone fragility and recurrent fractures. Emerging biologics demons...

Image-guided multiscale modeling of trabecular bone: lacuna-resolved stress amplification and interaction effects.

Osteocyte lacunae are ubiquitous microstructural cavities in bone that perturb local stress and strain fields, shaping the mechanical microenvironment...

Assessing the association of type 2 diabetes with skin health status: a study of the Northern Finland Birth Cohort 1966.

OBJECTIVES: There is evidence to suggest that alterations in skin health often co-occur with type 2 diabetes (T2D). However, the underlying mechanisms...

Intelligent kinematic physics engine construction for hyper-redundant cable-driven flexible manipulator.

To solve the problems of difficult kinematics modeling and poor real-time performance for a hyper-redundant cable-driven flexible manipulator, a const...

Hearing Loss in Older Adults: Consistent Determinants Across Two Community-Based Cohorts in Southern China.

BACKGROUND: Hearing loss (HL) is common in older adults and is associated with substantial functional decline, yet community-based evidence on its det...

Precision Transfusion Medicine in the Omics Era.

Transfusion medicine has practiced a form of precision medicine for decades through compatibility testing, infectious disease screening, component man...

Modeling and analysis of forward and inverse kinematics for a flexible Stewart platform.

Stewart platforms are widely used in flight simulators, precision machining, and other fields due to their advantages in high precision, high dynamic ...

Computational intelligence using nailfold videocapillaroscopy for the prediction of carotid intima-media thickness in rheumatoid arthritis: a cohort-based study.

Despite continuously evolving medical advances, CVD risk in Rheumatoid Arthritis (RA) remains paradoxically high to date. Carotid intima-media thickne...

Body composition's effect on the bone-vascular axis of osteoporosis discovered in AI-based CT analysis of COPD patients.

OBJECTIVES: This study aimed to investigate the effect of body composition on the inverse relationship between vertebral bone density (T12 BMD) and to...