Infectious Disease

Public Health

Latest AI and machine learning research in public health for healthcare professionals.

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Demographic Drivers of Epidemic Outcomes: Sensitivity Analysis of Multidimensional Parameters in the Covasim Model

Sensitivity analysis is a key tool for identifying which model inputs most strongly influence model outputs thereby informing data collection priorities. In agent-based models, these inputs include demographic parameters used to construct synthetic populations. Such parameters — age distributions, household size distributions, and contact matrices — are critical in shaping transmission dynamics. H...

From claims to care: Machine learning algorithm to classify urinary tract infection cases using Swiss health insurance data

To evaluate whether machine learning (ML) applied to comprehensive claims data without diagnostic codes can distinguish a high proportion of antibiotic treatment episodes as urinary tract infection (UTI) or non-UTI cases. Such approaches may be valuable for antimicrobial stewardship when diagnosis-linked datasets are unavailable. Outpatient antibiotic prescription claims from three major Swiss ins...

Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in Humans

Mucosal vaccines may reduce both infection and transmission by engaging local immunity, yet the immunological pathways they activate in humans remain ...

A Hybrid Deep Learning-Mechanistic Modeling Framework for Dengue Transmission Dynamics in Guangdong, China

Dengue fever is a mosquito-borne viral disease with strong seasonality, periodicity, and spatial heterogeneity, posing a persistent global public heal...

Urinary peptidomic signatures predict overall and progression-free survival in patients with bladder cancer

Clinicopathologic calculators for bladder cancer moderately predict survival and fail to depict the underlying molecular phenotype. We applied urinary...

A Prospective Real-time Early Warning System to Anticipate Onsets and Peaks of Respiratory Diseases Outbreaks at the State Level in the U.S. A Transfer Learning Approach Leveraging Digital Traces

Respiratory disease outbreaks burden U.S. healthcare systems with over one million hospitalizations annually, yet current surveillance systems lag 1-2...

Falls in Assisted Living Facilities: Can AI improve documentation and reduce injury?

Falls among elderly residents in assisted living facilities (ALFs) are prevalent, costly, and frequently under-documented. AUGi, a wall-mounted device...

Modelling Approaches for Predicting the Distribution of Skin NTDs: A Systematic Review

Skin neglected tropical diseases (NTDs) such as cutaneous leishmaniasis, lymphatic filariasis, mycetoma, and podoconiosis affect millions in endemic r...

Open-source solution for evaluation and benchmarking of large language models for public health

Large language models (LLMs) have demonstrated remarkable capabilities in various natural language processing tasks, including text classification, in...

Microscale Multiplexed Antigen-Specific Antibody Fc Profiling for Point-of-Care Diagnosis of Tuberculosis

Accurate, affordable tuberculosis (TB) diagnostics that do not require sputum samples are urgently needed for TB control and elimination. Prior serolo...

Discrete-Event Simulation Modeling Framework for Cancer Interventions and Population Health in R (DESCIPHR): An Open-Source Pipeline

Simulation models inform health policy decisions by integrating data from multiple sources and forecasting outcomes when there is a lack of comprehens...

A three-dose MVA-BN mpox vaccination series improves the quality of anti-monkeypox virus immunity

The 2022 global outbreak of clade IIb mpox represented a turning point in public health’s handling of poxviruses. The primary vaccine available for pr...

Science or Advocacy? The Global Rise of Policy Claims in Population Health Research (1990-2024)

Should original research routinely contain prominent policy claims, such as recommendations for policymakers or broad calls to action? Growing emphasi...

Fairness in infectious disease modeling

The concept of fairness has been extensively examined within the domains of Machine Learning and Artificial Intelligence more broadly. It remains, how...

Epidemiologic Method Review at Scale: Assessing Charlson Comorbidity Versioning Using a Large Language Model

The Charlson Comorbidity Index (CCI) is widely used in epidemiologic studies. However, many versions of the CCI have been developed since the original...

Pandemic-Potential Viruses are a Blind Spot for Frontier Open-Source LLMs

We study large language models (LLMs) for front-line, pre-diagnostic infectious-disease triage, a critically understudied stage in clinical interventi...

Integrating DHS/MIS Biomarkers with 34 Years of CHIRPS-NDVI Climate Data for Malaria Risk Prediction in Nigeria: A Machine Learning and Spatial Mapping Approach

The estimates of national disease risk are considerably limited by the time of conducted surveys and the geographical inadequacies in surveillance, no...

Estrogen upregulates NF-κB and TNF signaling in B cells to cause sex and age differences in antibody responses to seasonal influenza vaccination

Sex differences in the humoral immune responses to the seasonal quadrivalent influenza vaccine (QIV) in young adults (YA; 18-49yo) or high dose QIV in...

An exploration of current and future vector-borne disease threats and opportunities for change.

Vector-borne diseases, including dengue, threaten the health and livelihoods of over 80% of the world's population, particularly in tropical and subtr...

Jan 1 2025 40443936
Advancing Early Warning Systems for Malaria: Progress, challenges, and future directions - A scoping review.

Malaria Early Warning Systems (EWS) are predictive tools that often use climatic and other environmental variables to forecast malaria risk and trigge...

Jan 1 2025 40367150
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