Public Health

Enabling DCIS subtyping: leveraging foundation models for robust grading and molecular biomarker scoring.

Ductal Carcinoma In Situ (DCIS) is a non-obligate precursor of invasive breast cancer. Due to a lack of reliable prognostic markers, nearly all women with DCIS undergo intensive treatment-often unnecessarily. The LORD trial addresses this by offering active surveillance to women with screen-detected, ER-positive, HER2-negative, grade 1 or 2 DCIS, aiming to reduce overtreatment. To support this, we...

Design and in silico evaluation of an mRNA vaccine against HTLV-1 using AI-driven reverse vaccinology approaches.

Human T-lymphotropic virus type 1 (HTLV-1) is the first discovered human oncogenic retrovirus that can cause adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis, and several other diseases. Due to the poor prognosis of these diseases and the limited therapeutic modalities, the need for an HTLV-1 vaccine is crucial. The current study has used an artificial inte...

A Machine-Learning Approach to Predicting Adenoma Detection and Surveillance Impact of Deeper Sections in Colorectal Polypectomy Specimens.

CONTEXT.—: In the routine practice of pathology, cutting deeper levels into paraffin blocks of colorectal polypectomy specimens that do not show a les...

An epidemiological study of Parkinson's disease in Chinese older adults using the Global Burden of Disease and China Health and Retirement Longitudinal Study databases.

INTRODUCTION: The prevalence of Parkinson's disease (PD) has increased globally, especially in China, and emerged as a critical public health challeng...

Controlled human malaria infection in adults identify combinations of merozoite antigens associated with clinical immunity.

Two vaccines are currently licensed against Plasmodium falciparum malaria but offer only partial protection that wanes, necessitating repeated dosing ...

Harnessing AI and bioinformatics to combat methicillin-resistant staphylococcus aureus: Innovations in genomic surveillance, diagnosis, and therapeutic development.

The global rise of antimicrobial resistance (AMR), particularly methicillin-resistant Staphylococcus aureus (MRSA), poses a major health challenge, de...

Getting ahead of sudden cardiac arrest in pediatric hypertrophic cardiomyopathy patients.

INTRODUCTION: Sudden cardiac arrest (SCA) remains one of the most devastating complications of pediatric hypertrophic cardiomyopathy (HCM). Despite ma...

Risk and Protective Factors Associated With HIV-Related Mortality in Children Receiving Antiretroviral Therapy: A Model-Based Meta-Regression.

IMPORTANCE: Mortality among children and young adolescents receiving antiretroviral therapy (ART) remains substantially higher in resource-limited set...

Modelling approaches for predicting the distribution of skin NTDs: A systematic review.

BACKGROUND: Skin neglected tropical diseases (NTDs) such as cutaneous leishmaniasis, lymphatic filariasis, mycetoma, and podoconiosis affect millions ...

Methods for estimating the burden of acute tropical infectious diseases: A scoping review.

Acute infectious diseases, particularly lots of neglected tropical diseases (NTDs), pose significant public health challenges, especially in resource-...

AI-based prediction of dengue incidence using climatic, environmental, and socio-demographic factors: an ensemble random forest approach with agile system development.

BACKGROUND: Dengue transmission in Indonesia is shaped by interacting climatic, environmental, and socio-demographic factors, yet most forecasting sys...

The architecture of computational antiviralism: a multi-scale framework from molecular targeting to viral ecosystem engineering.

The recurrent outbreak of viral pathogens and the possibility of the new pandemics demand the transition to the predictive and integrative computation...

Climate and socioeconomic factors drive heterogeneous dengue risk escalation in the Chinese population.

BACKGROUND: Dengue risk is increasingly shaped by climate change and rapid urbanization, yet comprehensive, multidimensional risk assessments grounded...

Contemporary heart failure evidence in 2025: a joint summary of key trials from the European Journal of Heart Failure and ESC Heart Failure Journal.

Heart failure (HF) remains a major global health challenge, characterized by high morbidity, mortality, and healthcare costs despite substantial advan...

Advances in Avian Diagnostic Pathology: Current Trends, Challenges and Future Directions: A Review.

Avian pathology is the scientific study of diseases in birds, focusing on the structural, functional and molecular changes in tissues and organs cause...

Research priorities for improved pandemic and epidemic intelligence.

Pandemic and epidemic intelligence integrates surveillance data with contextual knowledge to assess health risks and inform public health decisions. A...

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response.

BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence larg...

AI for Hospital Infection Prevention and Control: Real-World Implementation, Impact, and the Gap Beyond Model Development.

BACKGROUND: Artificial intelligence and machine learning (AI/ML) may strengthen hospital infection prevention and control (IPC) through automated surv...

Evaluation of AI-enhanced FTIR spectroscopy for species and biovar typing of intracellular pathogenic Brucella spp.

BACKGROUND: Rapid and accurate identification of intracellular pathogenic Brucella species and biovars is essential for effective public health survei...

Revolutionizing lung cancer screening: the rise of artificial intelligence integrating circulating tumor markers.

Lung cancer persists as the predominant oncological cause of mortality globally, underscoring an imperative public health issue that demands effective...