Rheumatoid Arthritis

A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway.

Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the activation of the β-catenin-dependent canonical pathway or the β-catenin-independent non-canonical pathway. DKK1 is a potent inhibitor of Wnt signaling by competing with Wnt binding to LRP5/6 co-receptors. DKK1 is tumorigenic in multiple cancer types and immunosuppressive in NK cel...

Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer's disease.

The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accurately identify optimal candidates for anti-amyloid therapy, specifically those with evidence for incipient cognitive decline, since patients with mild cognitive impairment (MCI) may remain stable for several years even with positive AD biomarkers. Us...

Fluid fluctuations assessed with artificial intelligence during the maintenance phase impact anti-vascular endothelial growth factor visual outcomes in a multicentre, routine clinical care national age-related macular degeneration database.

AIM: To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in optical coherence tomography scans during the main...

Surfactant-Enhanced Anti-Swelling Hydrogel Flexible Sensor for Machine Learning-Assisted Underwater Gesture Recognition.

Hydrogels hold great promise as flexible sensors. However, the development of hydrogel sensors with exceptional anti-swelling properties and stable pe...

Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners.

Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction...

Lidocaine exhibits antileishmanial and immunomodulatory activities in an in vitro model of tegumentary leishmaniasis.

Local anesthetics have been shown to inhibit or delay the progression of tegumentary leishmaniasis (TL) in hamster models, although the mechanisms und...

Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most alarming antibiotic-resistant pathogens causing nosocomial and community-acquire...

Variations of the chemical components and biological activities of Thymus capitatus essential oil from three regions in Palestine.

Thymus capitatus is a widely utilized medicinal plant in Palestine. The main goal of this study was to assess the phytochemical content of T. capitatu...

Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.

OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of...

Diabetic retinopathy-recommendations for screening and treatment.

Diabetic retinopathy (DR), the prevalence of which continues to rise, is one of the most common causes of vision loss worldwide. Experimental and clin...

Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.

Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure t...

Gradient-driven deep penetration of self-electrophoretic nanoparticles in acidic tumor microenvironments for enhanced antitumor therapy.

Difficulty of nanomedicines to effectively penetrate the tumor core and achieve effective killing of tumor stem cells is an important factor leading t...

A sulfated fucopyranosyl-glucosamino-glucopyranose from marine heterotrophic Bacillus tequilensis regulates inflammatory cytokines in lipopolysaccharide-stimulated human monocyte THP-1 cells.

Marine macroalga or seaweed-associated bacterial exopolysaccharides, particularly (1 → 3)-linked β-glucans, possess potential ability to reduce inflam...

Mechanisms involved in pro-inflammatory responses to traffic-derived particulate matter (PM) in THP-1 macrophages compared to HBEC3-KT bronchial epithelial cells.

The pro-inflammatory responses in THP-1-derived macrophages and human bronchial epithelial cells (HBEC3-KT) were examined after exposure to size-fract...

Leafing a mark on immunity: Quercetin-3-O-D-glucopyranoside and quercetin-3-O-(2″,6″-digalloyl)-β-D-galactopyranoside-rich Melia azedarach L. extract's immunoinflammatory effects on an sRBC-immunized BALB/c model.

Melia azedarach L. (Meliaceae) (MA) leaves are traditionally used for inflammatory disorders, yet their immunomodulatory effects on lymphocytes remain...

Mechanisms and Applications of Apolipoproteins and Apolipoprotein Mimetic Peptides: Common Pathways in Cardiovascular Disease and Cancer.

Apolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprot...

Shared and Distinctive Inflammation-Related Protein Profiling in Idiopathic Inflammatory Myopathy with/without Anti-MDA5 Autoantibodies.

PURPOSE: Due to the heterogeneous nature of the diseases, treatment efficacy and prognosis vary for idiopathic inflammatory myopathy (IIM) patients wi...

Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species.

Deep learning-based methods have advanced animal pose estimation, enhancing accuracy, and efficiency in quantifying animal behavior. However, these me...

Comprehensive analysis of Syzygium cumini L. pomace extract as an α-amylase inhibitor: In vitro inhibition, kinetics, and computational studies.

Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder characterized by impaired regulation of blood glucose levels. Jamun (Syzygium cumin...

Predicting Visual Acuity after Retinal Vein Occlusion Anti-VEGF Treatment: Development and Validation of an Interpretable Machine Learning Model.

Accurate prediction of post-treatment visual acuity in macular edema secondary to retinal vein occlusion (RVO-ME) is critical for optimizing anti-VEGF...