Rheumatology

A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway.

Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the activation of the β-catenin-dependent canonical pathway or the β-catenin-independent non-canonical pathway. DKK1 is a potent inhibitor of Wnt signaling by competing with Wnt binding to LRP5/6 co-receptors. DKK1 is tumorigenic in multiple cancer types and immunosuppressive in NK cel...

Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes.

BACKGROUND: Monoclonal immunoglobulins are commonly found in multiple myeloma (MM), a prevalent hematologic malignancy that is currently incurable. In recent years, the association between systemic lupus erythematosus (SLE), an autoimmune disease, and MM has garnered increasing attention. However, there remains a lack of in-depth research regarding the interactions between these two conditions and...

Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer's disease.

The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accur...

Fluid fluctuations assessed with artificial intelligence during the maintenance phase impact anti-vascular endothelial growth factor visual outcomes in a multicentre, routine clinical care national age-related macular degeneration database.

AIM: To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in optical coherence tomography scans during the main...

Surfactant-Enhanced Anti-Swelling Hydrogel Flexible Sensor for Machine Learning-Assisted Underwater Gesture Recognition.

Hydrogels hold great promise as flexible sensors. However, the development of hydrogel sensors with exceptional anti-swelling properties and stable pe...

Aberrant formation of the neutrophil extracellular trap and the expression of the PLEKHA1 in systemic lupus erythematosus and ulcerative colitis.

Systemic lupus erythematosus (SLE) and ulcerative colitis (UC) are both chronic autoimmune diseases with unclear shared mechanisms, largely due to lim...

Performance of the Large Language Models in African rheumatology: a diagnostic test accuracy study of ChatGPT-4, Gemini, Copilot, and Claude artificial intelligence.

BACKGROUND: Artificial intelligence (AI) tools, particularly Large Language Models (LLMs), are revolutionizing medical practice, including rheumatolog...

Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.

BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumat...

From Multi-Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR-T Cell Therapy.

Chimeric antigen receptor T (CAR-T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological ma...

Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most alarming antibiotic-resistant pathogens causing nosocomial and community-acquire...

Variations of the chemical components and biological activities of Thymus capitatus essential oil from three regions in Palestine.

Thymus capitatus is a widely utilized medicinal plant in Palestine. The main goal of this study was to assess the phytochemical content of T. capitatu...

Diabetic retinopathy-recommendations for screening and treatment.

Diabetic retinopathy (DR), the prevalence of which continues to rise, is one of the most common causes of vision loss worldwide. Experimental and clin...

Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.

Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure t...

A new kind of polystyrene/polyethyleneimine nanofibres coordinated with palladium for fast and efficient extraction of methotrexate and its polyglutamate metabolites in different matrices.

Methotrexate (MTX) is a drug that has long been used in high doses as an anti-cancer drug and lately in low doses as a treatment for autoimmune diseas...

Gradient-driven deep penetration of self-electrophoretic nanoparticles in acidic tumor microenvironments for enhanced antitumor therapy.

Difficulty of nanomedicines to effectively penetrate the tumor core and achieve effective killing of tumor stem cells is an important factor leading t...

Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species.

Deep learning-based methods have advanced animal pose estimation, enhancing accuracy, and efficiency in quantifying animal behavior. However, these me...

Integrated bioinformatics, machine learning, and molecular docking reveal crosstalk genes and potential drugs between periodontitis and systemic lupus erythematosus.

Evidence indicates a connection between periodontitis (PD) and systemic lupus erythematosus (SLE), though the underlying co-morbid mechanisms remain u...

Referral patterns, influencing factors, and satisfaction related to referrals of patients with rheumatic diseases to other healthcare professionals: an online survey of rheumatologists.

Managing rheumatic diseases requires teamwork, but referral patterns and challenges remain poorly understood. This study explored rheumatologists' per...

Machine learning approach to single cell transcriptomic analysis of Sjogren's disease reveals altered activation states of B and T lymphocytes.

Sjogren's Disease (SjD) is an autoimmune disorder characterized by salivary and lacrimal gland dysfunction and immune cell infiltration leading to gla...

Comprehensive analysis of Syzygium cumini L. pomace extract as an α-amylase inhibitor: In vitro inhibition, kinetics, and computational studies.

Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder characterized by impaired regulation of blood glucose levels. Jamun (Syzygium cumin...