Rheumatology

Identification and validation of susceptibility modules and hub genes in polyarticular juvenile idiopathic arthritis using WGCNA and machine learning.

BACKGROUND: Juvenile idiopathic arthritis (JIA), superseding juvenile rheumatoid arthritis (JRA), is a chronic autoimmune disease affecting children and characterized by various types of childhood arthritis. JIA manifests clinically with joint inflammation, swelling, pain, and limited mobility, potentially leading to long-term joint damage if untreated. This study aimed to identify genes associate...

Comparison of the composition, immunological activity and anti-fatigue effects of different parts in sika deer antler.

BACKGROUND: Sika deer (, 1838) antler is a highly esteemed tonic renowned for its abundant assortment of polypeptides, polysaccharides, amino acids, and minerals, and is recognized for its multifarious pharmacological properties. However, limited research has been conducted regarding the variation in composition of deer antlers between the upper and basal sections, as well as their pharmacological...

Combination Therapy with Baricitinib and Narrowband Ultraviolet B for Active Non-Segmental Vitiligo: A Retrospective Controlled Study.

BACKGROUND: Vitiligo is a chronic autoimmune disease manifested by depigmented patches of skin devoid of melanocytes. Baricitinib, a JAK inhibitor sel...

Investigating the anti-obesity potential of leaf bioactive compounds through machine learning and computational biology methods.

Obesity, a growing global health concern, is linked to severe ailments such as cardiovascular diseases, type 2 diabetes, cancer, and neuropsychiatric ...

Machine Learning-Engineered Nanozyme System for Synergistic Anti-Tumor Ferroptosis/Apoptosis Therapy.

Nanozymes with multienzyme-like activity have sparked significant interest in anti-tumor therapy via responding to the tumor microenvironment (TME). H...

Serum PD-1 regulation and PD-1 expression of CD4+Foxp3+ regulatory T cells in patients in thyroid eye disease associated with immunosuppression treatment.

PURPOSE: Thyroid eye disease (TED) primarily occurs in hyperthyroid patients, sometimes resulting in poor visual prognosis. Although other autoimmune ...

How accurate are machine learning models in predicting anti-seizure medication responses: A systematic review.

IMPORTANCE: Current epilepsy management protocols often depend on anti-seizure medication (ASM) trials and assessment of clinical response. This may d...

Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum.

Primary human mast cells (MC) obtained through culturing of blood-derived MC progenitors are the preferred model for the study of MRGPRX2- IgE-media...

Quantitative fibrosis identifies biliary tract involvement and is associated with outcomes in pediatric autoimmune liver disease.

BACKGROUND: Children with autoimmune liver disease (AILD) may develop fibrosis-related complications necessitating a liver transplant. We hypothesize ...

BC99 alleviates hyperuricemia and oxidative stress via DAF-16/SKN-1 activation in .

INTRODUCTION: Hyperuricemia (HUA) refers to the presence of excess uric acid (UA) in the blood, which increases the risk of chronic kidney disease and...

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells.

BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. The...

Generative Adversarial Network-Based Augmentation With Noval 2-Step Authentication for Anti-Coronavirus Peptide Prediction.

The virus poses a longstanding and enduring danger to various forms of life. Despite the ongoing endeavors to combat viral diseases, there exists a ne...

Hyb_SEnc: An Antituberculosis Peptide Predictor Based on a Hybrid Feature Vector and Stacked Ensemble Learning.

Tuberculosis has plagued mankind since ancient times, and the struggle between humans and tuberculosis continues. Mycobacterium tuberculosis is the le...

Revolutionary drug repositioning: the preventive and therapeutic potential of metformin and other antidiabetic drugs in age-related macular degeneration.

Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Anti-vascular endothelial growth factor (anti-VEGF...

The isolation, bioactivity, and synthesis of natural products from with anti-HIV activities.

Natural products isolated from have attracted considerable attention from the chemical community due to their unique structures and promising anti-HI...

Cross-sectional Study on Medical Attitude Towards Artificial Intelligence Use in Fibromyalgia: Insights From the Annual Thinking Lab on Fibromyalgia Syndrome (ATLAS 2024).

BACKGROUND: The integration of artificial intelligence (AI) in healthcare has the potential to revolutionize clinical practice, particularly in the ma...

Machine learning-based prediction of antibiotic resistance in Mycobacterium tuberculosis clinical isolates from Uganda.

BACKGROUND: Efforts toward tuberculosis management and control are challenged by the emergence of Mycobacterium tuberculosis (MTB) resistance to exist...

Ontology-based integration and querying of heterogeneous rare disease data sources - POLVAS perspective.

The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are requ...

A Machine Learning-Based Prediction Model for the Probability of Fall Risk Among Chinese Community-Dwelling Older Adults.

Fall is a common adverse event among older adults. This study aimed to identify essential fall factors and develop a machine learning-based prediction...

anti-cancer activity of siddha metallo-mineral formulation from Thanga uram with Hela cell lines.

The second most common malignant tumour in women worldwide, cervical cancer seriously jeopardizes their health. It has been established that a high-ri...