Oncology/Hematology

Skin Cancer

Latest AI and machine learning research in skin cancer for healthcare professionals.

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Turep: Detecting cross-cancer tumor-reactive T cells in single-cell and spatial transcriptomics data

Tumor-infiltrating lymphocytes are essential for anti-tumor immunity, yet distinguishing tumor-react...

CT-Based Deep Foundation Model for Predicting Immune Checkpoint Inhibitor-Induced Pneumonitis Risk in Lung Cancer

Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but can cause ser...

Stylistic-STORM (ST-STORM) : Perceiving the Semantic Nature of Appearance

One of the dominant paradigms in self-supervised learning (SSL), illustrated by MoCo or DINO, aims t...

A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions

The interaction between T cell receptors (TCRs), peptides, and human leukocyte antigens (HLAs) under...

Transcriptomic Models for Immunotherapy Response Prediction Show Limited Cross-cohort Generalisability

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; yet substantial proportion of p...

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

Regional lymph node (LN) metastasis critically influences distant metastatic progression, anti-tumou...

A network-based deep learning model integrating subclonal architecture for therapy response prediction in cancer

Predicting treatment response remains challenging in oncology, particularly given the growing divers...

Unmasking Biases and Reliability Concerns in Convolutional Neural Networks Analysis of Cancer Pathology Images

Convolutional Neural Networks have shown promising effectiveness in identifying different types of c...

Rational Design of Selective IL-2-based Activators for CAR T Cells Using AlphaFold3 and Physics-Informed Machine Learning

Recombinant human Interleukin-2 (rhIL-2, Aldesleukin) is used in immunotherapy for metastatic melano...

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI

Identifying predictive biomarkers of immunotherapeutic response in melanoma remains an outstanding c...

SwiftTCR: Efficient Computational Docking protocol of TCRpMHC-I Complexes Using Restricted Rotation Matrices

The T cell's ability to discern self and non-self depends on its T cell receptor (TCR), which recogn...

A Lightweight Multi-Cancer Tumor Localization Framework for Deployable Digital Pathology

Accurate localization of tumor regions from hematoxylin and eosin-stained whole-slide images is fund...

A spatial multi-omic portrait of survival outcome for clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the leading cause of kidney cancer-related death, but how...

Towards Cross-Sample Alignment for Multi-Modal Representation Learning in Spatial Transcriptomics

The growing number of spatial transcriptomics (ST) datasets enables comprehensive multi-modal charac...

Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic Therapies

Differences in microbiome composition profoundly influence drug response, yet methods to model the m...

Can Agents Distinguish Visually Hard-to-Separate Diseases in a Zero-Shot Setting? A Pilot Study

The rapid progress of multimodal large language models (MLLMs) has led to increasing interest in age...

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