Smoking & Tobacco

Proteomic signatures of early retinal neurodegeneration in type 2 diabetes mellitus.

BACKGROUND: Retinal neurodegeneration is an early and independent feature of diabetic retinal disease and has been proposed as a window into the systemic neural consequences of diabetes, yet accessible molecular biomarkers and individualized prediction tools remain scarce. We aimed to identify circulating plasma protein signatures of diabetic retinal neurodegeneration (DRN) and to translate them i...

Using Machine Learning to Analyze the Predictors of Life Satisfaction: Focus on Lifestyle Attitudes and Psychological Factors.

OBJECTIVES: Life satisfaction is an essential indicator of quality of life, and enhancing it can contribute to individual well-being strategies. Because it is a complex concept, a comprehensive approach is needed to address it effectively. Machine learning offers a unique statistical opportunity to address this challenge effectively. In this study, we examined how lifestyle parameters, psychologic...

Beyond clinical predictors: Determining the impact of psychosocial factors in chronic pain after spinal cord injury.

UNLABELLED: ▒: Although chronic pain is common after traumatic SCI, prognostic models have traditionally prioritized clinical injury characteristics, ...

Deep learning-based CT-derived vertebral bone mineral density and metformin therapy: a longitudinal study in the Multi-Ethnic Study of Atherosclerosis.

OBJECTIVE: Evidence on metformin's skeletal effects remains conflicting. We emulated a target trial to evaluate associations between metformin therapy...

Investigating the Quality of Chat Generative Pretrained Transformer's Parenting Advice.

OBJECTIVES: Chat Generative Pretrained Transformer (ChatGPT) is a widely adopted tool that can provide immediate parenting guidance. The aim of this s...

Development and External Validation of a Machine Learning-Based Risk Classification Score for Prostate Cancer-Specific Cardiovascular Risk.

PURPOSE: Patients with prostate cancer (PC) face elevated cardiovascular (CV) risk. Conventional CV risk scores are often poorly calibrated for PC and...

Creation of an mHealth Infrastructure to Support the Development and Delivery of mHealth Interventions: Protocol for Demonstration Projects Addressing Smoking Cessation in Cancer Care.

BACKGROUND: Cancer remains a leading cause of morbidity worldwide. To reduce this burden, scalable, effective approaches are needed to address modifia...

Preoperative low-attenuation area on computed tomography is associated with recurrence after curative resection for non-small-cell lung cancer.

BACKGROUND: Recurrence after curative-intent resection remains a major determinant of long-term outcomes in non-small-cell lung cancer (NSCLC). Preope...

Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up.

UNLABELLED: Childhood obesity is rising globally. Yet, few studies have examined the microbiome and proteome in early childhood in relation to this ou...

Machine-learning-model based tool for screening bone metastases from lung cancer patients in primary care practice.

PURPOSE: This study aimed to use the machine-learning methods to predict bone metastasis (BM) in patients with lung cancer. METHODS: This study includ...

Genome-Wide Association Study and Fine Mapping Uncover Key Genetic Loci and Credible Genes of Intracranial Aneurysm and Aneurysmal Subarachnoid Hemorrhage.

BACKGROUND: Intracranial aneurysm (IA) is a common neurovascular disorder; rupture causes aneurysmal subarachnoid hemorrhage with high mortality. Desp...

Psychological distress in cancer survivors: a population-based analysis and machine learning-based risk stratification.

PURPOSE: As the number of cancer survivors increases, psychological distress has become an important issue. Using nationally representative data, we e...

Tobacco rattle virus triggers local defense and systemically coordinates taxoid biosynthesis in Taxus baccata revealed by integrated metabolic analysis.

The clinical demand for paclitaxel necessitates novel strategies to enhance its production. While recent breakthroughs have elucidated the complete bi...

Identifying critical windows of apparent temperature exposure and male serum reproductive hormone levels.

Although previous studies have suggested that environmental temperature may influence male reproductive hormone levels, evidence regarding the associa...

Machine learning-assisted single-cell Raman imaging for rapid, sensitive detection and intracellular mapping of carotenoids in plant cell cultures.

CRaman imaging combined with a multi-layer perceptron neural network enables non-destructive, label-freeclassifi cation of tobacco BY-2 cells based on...

An Explainable Machine Learning Model Integrating Transcranial Doppler and Clinical Data to Predict Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke.

BACKGROUND: Endovascular thrombectomy (EVT) has improved outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO); howe...

Identifying Key Predictors of Smoking Cessation Success: Text-Based Feature Selection Using a Large Language Model.

INTRODUCTION: The most effective way to reduce mortality and morbidity among current smokers is to quit smoking. Although about half of smokers attemp...

ChatGPT-4's Consistency, Specificity, and Inclusion of Behavior Change Techniques in Delivering Smoking Cessation Advice in Traditional Chinese: A Content Analysis.

INTRODUCTION: While ChatGPT has shown promise in health domains, its application in smoking cessation, particularly in non-English contexts, remains u...

Global incidence patterns of early-onset gastrointestinal cancers and their ecological associations with behavioural risk factors.

BACKGROUND: Early-onset gastrointestinal cancers (EOGIC) are increasingly recognised as an urgent global health concern. We aimed to describe the glob...

Effect of a Personalized Mobile Health Intervention Using Artificial Intelligence (the WARIFA App) Versus a Nonpersonalized Intervention on User-Defined Objectives, Healthy Lifestyles, and Management of Type 1 Diabetes (T1D): Protocol for a Randomized Controlled Trial.

BACKGROUND: Noncommunicable diseases are the leading cause of death worldwide. Cardiovascular and respiratory diseases, cancer, and type 2 diabetes sh...