Public Health & Policy

Stem Cell Research

Latest AI and machine learning research in stem cell research for healthcare professionals.

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A multi-scale graph frequency network for structural and functional region analysis in spatial transcriptomics.

Spatial transcriptomics enables the systematic exploration of how gene expression patterns are organized within intact tissues, yet effective analysis remains difficult due to the complexity of spatial dependencies and multi-scale tissue architectures. Here, we present the Spatial Graph Frequency Network (SGFN), a deep learning framework that integrates graph signal processing, graph attention, an...

Jul 6 2026 42402496

Vascular reprogramming in cancer: engineering the tumor microenvironment.

Tumor vasculature has traditionally been viewed as structurally and functionally abnormal and, therefore, is primarily targeted for inhibition. However, emerging evidence from vascular biology, regenerative medicine, and bioengineering challenges this paradigm, demonstrating that blood vessels actively instruct and shape the tumor microenvironment. Here, we propose that tumor vasculature functions...

Jul 5 2026 42402079
Artificial intelligence and CRISPR-based approaches for targeted delivery of bacteriophages.

The rapid emergence of multidrug-resistant (MDR) bacteria has increased interest in bacteriophage therapy as a promising alternative to conventional a...

Jul 5 2026 42402276
Multi-omics integration identifies macrophage senescence driven by the RUNX1-P53 axis as a key mechanism in diabetic foot ulcer.

Diabetic foot ulcer (DFU) is a severe complication of diabetes, characterized by chronic inflammation and impaired healing. Although cellular and immu...

Jul 4 2026 42399485
Multidimensional analysis of tumour immune microenvironment in HCC: prognostic significance and implications for immunotherapy.

BACKGROUND: The combination of immune checkpoint inhibitors (ICIs) and anti-angiogenic agents represents the standard first-line therapy for patients ...

Jul 3 2026 42397400
Real-Time Smartphone Monitoring Assessments as a Cognitive Biomarker of Alzheimer Disease: Protocol for a Development Study.

BACKGROUND: The diagnosis and monitoring of Alzheimer disease (AD) currently rely on clinician-administered, in-person, and cross-sectional pen-and-pa...

Jul 3 2026 42398039
Evaluation and Comparison of Latent Health Risk Prediction Models for Clinical Triage: Protocol for a Mixed Methods Study.

BACKGROUND: Clinical triage requires integrating multiple information sources to identify patients at risk of deterioration. Tools capturing global he...

Jul 3 2026 42398056
Advancing evidence-informed policy: outcomes of the global research agenda on knowledge translation.

BACKGROUND: Knowledge Translation (KT) research investigates methods to promote the uptake of research by practitioners, managers and policy-makers. R...

Jul 2 2026 42393681
Dihydroberberine regulates the ferroptosis-autophagy positive feedback loop in colorectal cancer by targeting PANX2.

BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major clinical challenge, underscoring the urgent n...

Jul 1 2026 42401068
Integrative multi-omics and machine learning reveal PLAUR as a Pan-Cancer prognostic biomarker and potential therapeutic target.

Tumor heterogeneity remains a major barrier to effective cancer therapy, driving the need for novel biomarkers and targeted strategies. A bibliometric...

Jul 1 2026 42391812
Definitions and Severity/Risk Prediction Tools for Bronchopulmonary Dysplasia: A Scoping Review.

BACKGROUND: Bronchopulmonary dysplasia (BPD) remains a major complication of extreme prematurity, but diagnosis and severity classification have becom...

Jul 1 2026 42383483
Modelling stem cell differentiation related processes-A practical overview for biologists.

Stem cell differentiation is central to development and regenerative medicine, but the complex underlying processes hinder our ability to control it e...

Jul 1 2026 42384568
AI-driven therapeutic antisense oligonucleotide for processing-deficient progeroid laminopathies.

BACKGROUND: Progeroid laminopathies (PLs), including Hutchinson-Gilford progeria syndrome (HGPS), are rare premature aging disorders in which cardiova...

Jul 1 2026 42385712
Digital divide in clinical and operational artificial intelligence adoption and implementation stages: US hospital diffusion patterns and AI deserts.

OBJECTIVES: We examine how hospital characteristics relate to clinical and operational artificial intelligence (AI) adoption and implementation stages...

Jul 1 2026 42386166
Exploring tuberculosis physicians' preferences for AI explainability in China: a protocol for a discrete choice experiment.

INTRODUCTION: Artificial intelligence (AI) is increasingly used in tuberculosis (TB) diagnosis, but its clinical adoption depends not only on accuracy...

Jul 1 2026 42386291
Ethics of not knowing who we are talking to in qualitative research.

The increasing use of online methods in qualitative research, alongside the growing availability of artificial intelligence tools, has raised concerns...

Jul 1 2026 42386380
Inpatient Robotic Therapy for Stroke Survivors With Severe Upper Limb Impairments: A Randomized Controlled Trial.

IMPORTANCE: Understanding how upper extremity (UE) robotic therapy (RT) affects efficiency and effectiveness of inpatient rehabilitation is important ...

Jul 1 2026 42207708
Survivor Perspectives on Artificial Intelligence Integration in Breast Cancer Treatment: A Qualitative Study of Trust, Equity, and Application.

FUNDING: Funding (NIH #1OT2OD037972-01). OBJECTIVE: Artificial intelligence (AI) may enhance the efficiency and personalization of breast cancer (BC) ...

Jul 1 2026 42317094
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.

The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolv...

Jul 1 2026 42380095
10 recommendations for strengthening citizen science for improved societal and ecological outcomes: A co-produced analysis of challenges and opportunities in the 21st century.

Citizen science plays an increasingly important role in generating scientific knowledge and supporting environmental and social action. However, its p...

Jul 1 2026 42384735
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