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A DNA foundation model predicts osteoporosis risk genes without proximity bias

Targets supported by human genetic associations are more than twice as likely to progress from clini...

Transformer-Based Multi-Region Segmentation and Radiomic Analysis of HR-pQCT Imaging for Osteoporosis Classification

Osteoporosis is a skeletal disease typically diagnosed using dual-energy X-ray absorptiometry (DXA),...

Transformer-Based Multi-Region Segmentation and Radiomic Analysis of HR-pQCT Imaging

Osteoporosis is a skeletal disease typically diagnosed using dual-energy X-ray absorptiometry (DXA),...

Association of Radiologic PPFE Change with Mortality in Lung Cancer Screening Cohorts

Background: Pleuroparenchymal fibroelastosis (PPFE) is an upper lobe predominant fibrotic lung abnor...

Sleep Disruption Improves Performance in Simple Olfactory and Visual Decision-Making Tasks

Sleep disruption drastically impacts cognitive functions including decision-making and attention acr...

Deep Learning-based Differentiation of Drug-induced Liver Injury and Autoimmune Hepatitis: A Pathological and Computational Approach

Drug-induced liver injury (DILI) is an acute inflammatory liver disease caused not only by prescript...

AI-Driven Generation of Cortisol-Binding Peptides for Non-Invasive Stress Detection

Cortisol is a primary biomarker of stress, released in sweat at concentrations that directly correla...

Spatial multi-omics identify an immunosuppressive lipid-laden macrophage niche in primary CNS lymphoma

Primary central nervous system lymphoma (PCNSL) is a subtype of diffuse large B-cell lymphoma (DLBCL...

Development and cross-tissue validation of a methylation profile score for the cortisol response to stress

Hypothalamic-pituitary-adrenal axis (HPA axis) dysregulation is a risk factor for poor mental and ph...

Gender-Specific Osteoporosis Risk Prediction Using Longitudinal Clinical Data and Machine Learning

Osteoporosis is a silent yet debilitating disease that often remains undetected until fractures occu...

Comp2Comp: Open-Source Software with FDA-Cleared Artificial Intelligence Algorithms for Computed Tomography Image Analysis

Artificial intelligence allows automatic extraction of imaging biomarkers from already-acquired radi...

Single center Automated, Multi-Source deeply Phenotyped Heart Transplant Registry as a template to build tailored data infrastructure

Background: Traditional heart transplant registries often lack the granularity required for deep phe...

Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function

Glucocorticoids (GCs) coordinate immunity, inflammation and metabolism through allosteric regulation...

Breast cancer radiogenomics analysis via computational perturbation on AI-driven multi-omics guided image synthesis

Radiogenomics offers a promising non-invasive approach for characterizing breast cancer (BC), yet it...

Pharmacogenomic Determinants of Post-Liver Transplant Diabetes Mellitus: A Systematic Review and In Silico Pharmacogenomic Analysis

Introduction: Tacrolimus remains central to liver transplantation, yet its narrow therapeutic index ...

Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.

Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). ...

Dec 2025 40369954
Explainable artificial intelligence for prediction of refractory ulcerative colitis: analysis of a Japanese Nationwide Registry.

OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which remission is de...

Dec 2025 40323686
Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.

BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset a...

Sep 2025 40381861
A Machine Learning Approach to Molecular Initiating Event Prediction Using High-Throughput Transcriptomic Chemical Screening Data.

Improved scalability of high-throughput RNA-sequencing technologies has contributed to their propose...

Jul 2025 40592767
Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects.

Cellular senescence is a complex biological process with a dual role in tissue homeostasis and aging...

Jul 2025 40412763
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