Transplantation

AI-based bone age assessment versus forensic expert panel: agreement, sex bias, and ethical implications.

BACKGROUND: Forensic age estimation is frequently requested when chronological age is unknown or contested. While automated bone age systems have been validated in clinical populations, their performance against committee-based forensic reference standards-and their compatibility with the AGFAD-compliant Mindestalter (minimum chronological age) framework-has not been systematically addressed in ca...

Cracking the code of heatstroke: new insights into diagnosis and pathological mechanisms.

As global temperatures continue to rise, the incidence and mortality rates of heatstroke (HS) have significantly increased. However, the current forensic diagnostic standards lack clear pathological criteria for deaths caused by HS, and the mechanisms of multi-organ damage induced by HS are not yet fully understood. In this study, a rat model of HS-induced death was established under conditions of...

Targeting the Gut-Heart Axis in Atherosclerosis: Microbial Metabolites, Molecular Mechanisms, and Precision Therapeutics.

Despite advances in lipid-lowering and anti-inflammatory medications, atherosclerotic cardiovascular disease (ASCVD) continues to be the leading cause...

Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates.

gem-Difluorophosphonates are pivotal structural motifs in pharmaceuticals and bioactive molecules. While photoenzymatic catalysis provides a powerful ...

Machine Learning-Driven Discovery of Indole/Oxoindole-Piperazine Scaffolds as Dual MAO-B/Sig-1R Ligands for Neurodegenerative Disorders.

The monoamine oxidase B (MAO-B) enzyme and Sigma-1 (Sig-1R) receptor are therapeutically relevant targets implicated in neurodegenerative and neuropsy...

Integrative transcriptomics, machine learning, and molecular docking derive a DAM-like macrophage signature for risk stratification and therapeutic nomination in glioblastoma.

Glioblastoma presents a significant challenge for drug development due to its complex immunosuppressive microenvironment. Identifying candidate therap...

Spatial transcriptome and single-cell reveal the role of sorbitol metabolism in hepatocellular carcinoma progression and tumor microenvironment.

BACKGROUND: Metabolic reprogramming represents a hallmark feature of hepatocellular carcinoma (HCC). As a crucial branch of the polyol pathway, the bi...

Pangenome-guided immunoinformatics design and in silico characterization of a multi-epitope vaccine candidate against Acinetobacter baumannii with nanoparticle assembly potential.

Acinetobacter baumannii is a critical multidrug-resistant pathogen causing severe healthcare infections with high mortality, yet no licensed vaccine e...

Clinical trials and evaluation of AI tools in solid organ transplantation: implications for clinical care, regulatory science, and rare diseases.

Artificial Intelligence (AI) has widespread applications in solid organ transplantation (SOT), a field that fundamentally depends on optimizing comple...

Heatstroke Over the Past Decade: Risk Factors, Long-Term Health Consequences, and Preventive Measures.

BACKGROUND: Heatstroke (HS) encompasses acute multi-organ dysfunction and increases susceptibility to subsequent heat-related conditions, making timel...

Prioritization of molecular signatures between BDE-209-relevant targets and ulcerative colitis: a network toxicology and bioinformatics analysis.

BACKGROUND: Decabromodiphenyl ether (BDE-209) is a widely used flame retardant and persistent environmental contaminant. However, the overlap between ...

Navigating Acceptability: A Think-Aloud Study of Subjective and Contextual Factors in Radiographic Image Rejection.

INTRODUCTION: Radiographic image quality is evaluated based on technical and anatomical criteria; however, this study investigates how radiographers i...

Bridging Organ-on-a-Chip and Omics: A Multi-Dimensional Frontier in Biomedical Research.

Organ-on-a-Chip (OOC) technology offers a powerful platform for replicating human tissue-specific microenvironments, thereby narrowing the translation...

Current Advances and Navigating the Complexities of SVG-PCI.

Saphenous vein graft (SVG) percutaneous coronary intervention (PCI) remains technically challenging and clinically high risk due to the friable, throm...

Precision Transfusion Medicine in the Omics Era.

Transfusion medicine has practiced a form of precision medicine for decades through compatibility testing, infectious disease screening, component man...

Surface Mounted Metal-Organic Frameworks for Advanced Sensing: Construction Strategies, Recent Applications, and Emerging Opportunities With Artificial Intelligence.

Sensors play a vital role in modern production and daily life, where high sensitivity, selectivity, and device integration are increasingly required. ...

Explainable AI for employee turnover prediction: a SHAP-based intelligent analytics approach.

Employee turnover prediction is a critical challenge in human resource management. Existing studies emphasise predictive accuracy but generally treat ...

A population-based retrospective machine learning study of COVID-19 severity using integrated clinical and viral genomic data in Jiangsu Province, China.

BACKGROUND: As coronavirus disease 2019 (COVID-19) has transitioned into an endemic phase characterized by sustained transmission and widespread hybri...

AI-driven neoantigen identification: a comprehensive review from somatic variant calling to T cell recognition.

BACKGROUND: Neoantigens-tumor-specific peptides generated by somatic mutations-are central targets of effective anticancer T cell immunity and underpi...

A Novel Dosing Strategy for Tacrolimus in Lung Transplant Recipients: Integrating Machine Learning with Population Pharmacokinetic Analysis.

BACKGROUND: Integrating machine learning (ML) with population pharmacokinetic (PPK) modeling may improve therapeutic drug monitoring predictions. METH...