Transplantation

Body Charts from CT Segmentations across the Adult Lifespan: Large-scale Cross-sectional and Longitudinal Analyses.

Purpose To model the distribution of CT-derived whole-body anatomic volumes across adulthood and establish comprehensive cross-sectional and longitudinal reference charts, addressing the current lack of nonbrain CT-based whole-body standards. Materials and Methods Retrospective CT scans acquired from March 2017 to April 2025 (189 710 scans, 106 563 patients) from the institutional picture archivin...

Cancer-associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi-omics and machine learning analysis.

Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer-associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various pathophysiological mechanisms. We analyzed a total of 1,0...

Polyanion-stabilized amorphous halide electrolytes with low lithium content for all-solid-state lithium batteries.

Lithium halide solid electrolytes have garnered significant attention owing to their high ionic conductivity and positive electrode compatibility. How...

Integrated Single-Cell and Bulk Transcriptome Analysis Reveals the Prognostic Significance and Immune Regulatory Mechanisms of Sialylation in Hepatocellular Carcinoma.

Liver Hepatocellular Carcinoma (LIHC) is a high-mortality primary liver cancer. Its treatment and prognosis are highly dependent on disease stage and ...

Helping people navigate and make sense of cancer information: challenges and perspectives.

People living with cancer, and their caregivers and families, have access to many sources of health information. This brings both positives and challe...

IntelliScheduler: an edge-cloud computing environment hybrid deep learning framework for task scheduling based on learning.

Edge-cloud computing has emerged as an important paradigm for modern Internet of Things (IoT) workflow applications, enabling low latency and on-deman...

UHRF2 related to sumoylation : assessment of its role in immune suppression and therapeutic potential in colorectal cancer.

SUMOylation is a critical post-translational modification of proteins. However, the roles of SUMOylation-related genes in regulating the tumor immune ...

Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application.

Mesenchymal stromal cells (MSCs) possess potent immunomodulatory, pro-angiogenic, and regenerative capacities, offering broad clinical promise in rege...

Benchmarking spectroscopic-chemometric models for human bloodstain time since deposition in tropical outdoor microenvironments.

Reliable estimation of the time since deposition (TSD) of bloodstains remains a key challenge in forensic reconstruction, particularly under realistic...

Precise, fast, and automated gel quantification powered by YOLO11 instance segmentation.

BACKGROUND: Gel electrophoresis is a cornerstone technique in analytical chemistry and proteomics, yet downstream image analysis remains a bottleneck ...

Beyond the Cage: The Rise and Promise of Non-Animal Models in Biomedical Research.

The accelerating shift in biomedical research toward human-relevant, ethical, and innovative methodologies has propelled the adoption of Non-animal mo...

CXCL9 as a key feature for deep learning-based immune subtyping and prediction of immune checkpoint blockade response in triple-negative breast cancer.

BACKGROUND: Immune checkpoint blockade (ICB) therapy has provided a promising treatment option for patients with triple-negative breast cancer (TNBC)....

Quantum Sensing for Precision Organ Aging Assessment.

Aging proceeds heterogeneously across organs, making chronological age an inadequate measure of physiological decline. The concept of organ biological...

Comprehensive recommendations for the implementation of artificial intelligence in healthcare: a narrative review on facilitators and barriers.

OBJECTIVES: The integration of artificial intelligence (AI) technologies into clinical practice holds significant promise for enhancing healthcare del...

Association between hypothermic machine perfusion parameters and graft function in deceased donor kidney transplantation.

BACKGROUND: Kidney transplantation (KT) is the most effective treatment for end-stage renal disease. Hypothermic machine perfusion (HMP) can improve r...

Pure Chitosan Microfluidic Spinning Affords Modular Core-Sheath Fibers and Hand-Crafted Scaffolds with Enhanced Fibroblast Compatibility.

Microfluidic-spun hydrogel fibers are appealing for tissue engineering and cell transplantation applications, as they give access to fiber-shaped tiss...

Anatomic Features of the Abdomen Predict Donor Site Complications in Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction: A Machine Learning Approach.

BACKGROUND: Abdominal donor site complications remain significant concerns in Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction. I...

Artificial intelligence in pediatric nephrology: current applications and emerging frameworks for evidence generation.

Artificial intelligence (AI) is rapidly transforming many areas of medicine. Pediatric nephrology may be a field of particular relevance due to its da...

Phosphoenolpyruvate carboxykinase 2 as a prognostic biomarker: expression and clinical significance in Group 3 and Group 4 medulloblastoma.

PURPOSE: Despite Phosphoenolpyruvate carboxykinase 2 (PCK2) has attracted growing attention as a potential biomarker in cancer research, its role in m...

A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance.

The expansion and potentiation of regulatory T cells (Treg cells) offer an appealing approach for achieving immune tolerance and controlling overactiv...